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Electrophysiological characteristics of injured peripheral nerves

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Mechanisms and Mediators of Neuropathic Pain

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Injury of a peripheral nerve interrupts the centripetal action potential conduction in axons of many sensory neurons. Since it is the peripheral, receptive ending that is the only part of the sensory neuron specialised for action potential generation under normal conditions, one would expect proximal parts of sensory neurons to become and remain silent following injury. Consequently, patients with peripheral nerve lesions should complain of sensory deficits.

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Authors and Affiliations

  1. Aventis Pharma Deutschland, Industriepark Hoechst, Building H821, 65926, Frankfurt/Main, Germany

    Martin Michaelis

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  1. NeurogesX, Inc., 969C Industrial Road, San Carlos, CA, 94070, USA

    Annika B. Malmberg PhD

  2. RW Johnson Pharmaceutical Institute, 3210 Merryfield Row, San Diego, CA, 92121, USA

    Sandra R. Chaplan MD

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Michaelis, M. (2002). Electrophysiological characteristics of injured peripheral nerves. In: Malmberg, A.B., Chaplan, S.R. (eds) Mechanisms and Mediators of Neuropathic Pain. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8129-6_1

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  • DOI: https://doi.org/10.1007/978-3-0348-8129-6_1

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9448-7

  • Online ISBN: 978-3-0348-8129-6

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