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Mast cell involvement in neurogenic inflammation

  • Chapter
Migraine: A Neuroinflammatory Disease?

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Mast cells derive from a distinct precursor in the bone marrow [1] and migrate into most tissues, where they acquire distinct characteristics in response to different micro-environmental influences, such as stem cell factor, nerve growth factor, or the cytokines, interleukin (IL)-3, -4 and -6 [2]. Mast cells are responsible for allergic reactions but mounting evidence indicates that they also participate in inflammation [3, 4] and homeostasis [5]. They are present in the meninges [6–11], especially the dura mater, which contains a large proportion of the total intracranial histamine [12]. The mast cells in the dura resemble those in connective tissue since they stain metachromatically with toluidine blue [13] and immunohistochemically for rat mast-cell protease I [14]. Connective-tissue mast cells and mucosal mast cells vary considerably in their staining characteristics as well as in their cytokine content [2, 15]. The mast cells in the rat dura mater, staining violet with toluidine blue, are often seen next to blood vessels (Fig. 1A). This close association with blood vessels can be appreciated better with electron microscopy, showing mast cells “embracing” the endothelial cells that make up the blood vessel wall (Fig. 1B).

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  1. New England Medical Center, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 0211, USA

    Theoharis C. Theoharides & Kristiana Kandere

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  1. Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA

    Egilius L. H. Spierings

  2. Headache Unit, Department of Neurology, Fundación Hospital Alcorcón Juan Carlos I University, Madrid, Spain

    Margarita Sánchez del Río

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Theoharides, T.C., Kandere, K. (2002). Mast cell involvement in neurogenic inflammation. In: Spierings, E.L.H., Sánchez del Río, M. (eds) Migraine: A Neuroinflammatory Disease?. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8131-9_7

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  • DOI: https://doi.org/10.1007/978-3-0348-8131-9_7

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9449-4

  • Online ISBN: 978-3-0348-8131-9

  • eBook Packages: Springer Book Archive

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