Skip to main content
SpringerLink
Log in

The role of eotaxin and related CC-chemokines in asthma and allergy

  • Conference paper
Inflammatory Processes:

Part of the book series: Progress in Inflammation Research ((PIR))

  • 177 Accesses

Abstract

The response to exposure to an aeroallergen in an allergic asthmatic consists of an initial bronchoconstriction associated with cross-linking of IgE on mast cells and the release of spasmogens, followed (except in mild reactions) by a late phase bronchoconstriction. The late phase bronchoconstriction is associated with an infiltration of airway tissue by inflammatory cells. These inflammatory changes are thought to underlie the airway hyper-responsiveness to spasmogens which is a characteristic of asthma.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kameyoshi Y, Dorschner A, Mallet AI, Christophers E, Schroder JM (1992) Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J Exp Med 176 (2): 587–592

    Article  PubMed  CAS  Google Scholar 

  2. Jose PJ, Griffiths-Johnson DA, Collins PD et al (1994) Eotaxin: a potent chemoattractant cytokine detected in a guinea-pig model of allergic airways inflammation. J Exp Med 179: 881–887

    Article  PubMed  CAS  Google Scholar 

  3. Jose PJ, Adcock IM, Griffiths-Johnson DA et al (1994) Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs. Biochem Biophys Res Commun 205 (1): 788–794

    Article  PubMed  CAS  Google Scholar 

  4. Rothenberg ME, Luster AD, Leder P (1995) Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumour suppression. Proc Natl Acad Sci USA 92: 8960–8964

    Article  PubMed  CAS  Google Scholar 

  5. Gonzalo JA, Jia GQ, Aguirre V et al (1996) Mouse eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response. Immunity 4 (1): 1–14

    Article  CAS  Google Scholar 

  6. Ponath PD, Qin S, Ringler DJ et al (1996) Cloning of the human eosinophil chemoat tractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest 97: 604–612

    Article  PubMed  CAS  Google Scholar 

  7. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (1996) Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med 2 (4): 449–56

    Article  PubMed  CAS  Google Scholar 

  8. Williams CMM, Newton DJ, Wilson SA, Williams TJ, Coleman JW, Flanagan BF (1998) Conserved structure and tissue expression of rat eotaxin. Immunogenetics 47: 178–180

    Article  PubMed  CAS  Google Scholar 

  9. Ishi Y, Shirato M, Nomura A et al (1998) Cloning of rat eotaxin: ozone inhalation increases mRNA and protein expression in lungs of brown Norway rats. Am J Physiol 274 (1 Pt 1): L171–176

    PubMed  CAS  Google Scholar 

  10. Shaw G, Kamen R (1986) A conserved AU sequence from the 3’ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46 (5): 659–667

    Article  PubMed  CAS  Google Scholar 

  11. Chen CY, Shyu AB (1995) AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem Sci 20 (11): 465–470

    Article  PubMed  CAS  Google Scholar 

  12. Forssmann U, Uguccioni M, Loetscher P et al (1997) Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. J Exp Med 185 (12): 2171–2176

    Article  PubMed  CAS  Google Scholar 

  13. White JR, Imburgia C, Dul E et al (1997) Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. J Leukoc Biol 62: 667–675

    PubMed  CAS  Google Scholar 

  14. Kitaura M, Suzuki N, Imai T et al (1999) Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J Biol Chem 274 (39): 27975–27980

    Article  PubMed  CAS  Google Scholar 

  15. Shinkai A, Yoshisue H, Koike M et al (1999) A novel human CC chemokine, eotaxin 3, which is expressed in IL-4- stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J Immunol 163 (3): 1602–1610

    PubMed  CAS  Google Scholar 

  16. Garcia-Zepeda EA, Rothenberg ME, Weremowicz S, Sarafi MN, Morton CC, Luster AD (1997) Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine. Genomics 41 (3): 471–476

    Article  PubMed  CAS  Google Scholar 

  17. Nomiyama H, Osborne LR, Imai T et al (1998) Assignment of the human CC chemokine MPIF-2/eotaxin-2 (SCYA24) to chromosome 7q11.23. Genomics 49 (2): 339–340

    Article  PubMed  CAS  Google Scholar 

  18. Weber M, Uguccioni M, Ochensberger B, Baggiolini M, Clark-Lewis I, Dahinden CA (1995) Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. J Immunol 154 (8): 4166–4172

    PubMed  CAS  Google Scholar 

  19. Garcia-Zepeda EA, Combadiere C, Rothenberg ME et al (1996) Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol 157 (12): 5613–5626

    PubMed  CAS  Google Scholar 

  20. Uguccioni M, Loetscher P, Forssmann U et al (1996) Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. J Exp Med 183: 2379–2384

    Article  PubMed  CAS  Google Scholar 

  21. Stellato C, Collins P, Ponath PD et al (1997) Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. J Clin Invest 99 (5): 926–936

    Article  PubMed  CAS  Google Scholar 

  22. Naruse K, Ueno M, Satoh T et al (1996) A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics 34 (2): 236–240

    Article  PubMed  CAS  Google Scholar 

  23. Hein H, Schluter C, Kulke R, Christophers E, Schroder JM, Bartels J (1999) Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines. Biochem Biophys Res Commun 255 (2): 470–476

    Article  PubMed  CAS  Google Scholar 

  24. Ueda A, Okuda K, Ohno S et al (1994) NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J Immunol 153 (5): 2052–2063

    PubMed  CAS  Google Scholar 

  25. Beato M (1989) Gene regulation by steroid hormones. Cell 56 (3): 335–344

    Article  PubMed  CAS  Google Scholar 

  26. Hein H, Schluter C, Kulke R, Christophers E, Schroder JM, Bartels J (1997) Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene. Biochem Biophys Res Commun 237 (3): 537–542

    Article  PubMed  CAS  Google Scholar 

  27. Lilly CM, Nakamura H, Kesselman H et al (1997) Expression of eotaxin by human lung epithelial cells: induction by cytokines and inhibition by glucocorticoids. J Clin Invest 99 (7): 1767–1773

    Article  PubMed  CAS  Google Scholar 

  28. Stellato C, Beck LA, Gorgone GA et al (1995) Expression of the chemokine RANTES by a human bronchial epithelial cell line. Modulation by cytokines and glucocorticoids. J Immunol 155 (1): 410–418

    PubMed  CAS  Google Scholar 

  29. Kwon OJ, Jose PJ, Robbins RA, Schall TJ, Williams TJ, Barnes PJ (1995) Glucocorticoid inhibition of RANTES expression in human lung epithelial cells. Am J Respir Cell Mol Biol 12 (5): 488–496

    PubMed  CAS  Google Scholar 

  30. Ponath PD, Qin S, Post TW et al (1996) Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med 183: 2437–2448

    Article  PubMed  CAS  Google Scholar 

  31. Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (1996) Cloning, expression, and characterization of the human eosinophil eotaxin receptor. J Exp Med 183: 2349–2354

    Article  PubMed  CAS  Google Scholar 

  32. Kitaura M, Nakajima T, Imai T et al (1996) Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J Biol Chem 271 (13): 7725–7730

    Article  PubMed  CAS  Google Scholar 

  33. Gao J-L, Sen AI, Kitaura M et al (1996) Identification of a mouse eosinophil receptor for the CC chemokine eotaxin. Biochem Biophys Res Commun 223: 679–684

    Article  PubMed  CAS  Google Scholar 

  34. Post TW, Bozic CR, Rothenberg ME, Luster AD, Gerard N, Gerard C (1995) Molecular characterization of two murine eosinophil beta chemokine receptors. J Immunol 155 (11): 5299–5305

    PubMed  CAS  Google Scholar 

  35. Sabroe I, Conroy DM, Gerard NP et al (1998) Cloning and characterization of the guinea pig eosinophil eotaxin receptor, CCR3: blockade using a monoclonal antibody in vivo. J Immunol 161: 6139–6147

    PubMed  CAS  Google Scholar 

  36. Heath H, Qin S, Rao P et al (1997) Chemokine receptor usage by eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest 99: 178–184

    Article  PubMed  CAS  Google Scholar 

  37. Sabroe I, Hartnell A, Jopling LA et al (1999) Differential regulation of eosinophil chemokine signalling via CCR3 and non-CCR3 pathways. J Immunol 162: 2946–2955

    PubMed  CAS  Google Scholar 

  38. Uguccioni M, Mackay CR, Ochensberger B et al (1997) High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. J Clin Invest 100 (5): 1137–1143

    Article  PubMed  CAS  Google Scholar 

  39. Sallusto F, Mackay CR, Lanzavecchia A (1997) Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277 (5334): 2005–2007

    Article  PubMed  CAS  Google Scholar 

  40. Gerber BO, Zanni MP, Uguccioni M et al (1997) Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils. Current Biology 7: 836–843

    Article  PubMed  CAS  Google Scholar 

  41. Bonecchi R, Bianchi G, Bordignon PP et al (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (This) and Th2s. J Exp Med 187 (1): 129–134

    Article  PubMed  CAS  Google Scholar 

  42. Collins PD, Marleau S, Griffiths-Johnson DA, Jose PJ, Williams TJ (1995) Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med 182: 1169–1174

    Article  PubMed  CAS  Google Scholar 

  43. Humbles AA, Conroy DM, Marleau S et al (1997) Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo. J Exp Med 186 (4): 601–612

    Article  PubMed  CAS  Google Scholar 

  44. Griffiths-Johnson DA, Collins PD, Rossi AG, Jose PJ, Williams TJ (1993) The chemokine, eotaxin, activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo. Biochem Biophys Res Commun 197 (3): 1167–1172

    Article  PubMed  CAS  Google Scholar 

  45. Rothenberg ME, Luster AD, Lilly CM, Drazen JM, Leder P (1995) Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. J Exp Med 181 (3): 1211–1216

    Article  PubMed  CAS  Google Scholar 

  46. MacLean JA, Ownbey R, Luster AD (1996) T cell-dependent regulation of eotaxin in antigen-induced pulmonary eosinophila. J Exp Med 184 (4): 1461–1469

    Article  PubMed  CAS  Google Scholar 

  47. Rothenberg ME, MacLean JA, Pearlman E, Luster AD, Leder P (1997) Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med 185 (4): 1–6

    Article  Google Scholar 

  48. Yang Y, Loy J, Ryseck RP, Carrasco D, Bravo R (1998) Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine eotaxin. Blood 92 (10): 3912–3923

    PubMed  CAS  Google Scholar 

  49. Sousa AR, Lane SJ, Nakhosteen JA, Yoshimura T, Lee TH, Poston RN (1994) Increased expression of the monocyte chemoattractant protein-1 in bronchial tissue from asthmatic subjects. Am J Respir Cell Mol Biol 10 (2): 142–147

    PubMed  CAS  Google Scholar 

  50. Humbert M, Ying S, Corrigan C et al (1997) Bronchial mucosal expression of the genes encoding chemokines RANTES and MCP-3 in symptomatic atopic and nonatopic asthmatics: relationship to the eosinophil-active cytokines interleukin (IL)-5, granulocyte macrophage-colony-stimulating factor, and IL-3. Am J Respir Cell Mol Biol 16 (1): 1–8

    PubMed  CAS  Google Scholar 

  51. Luster AD, Rothenberg ME (1997) Role of the monocyte chemoattractant protein and eotaxin subfamily of chemokines in allergic inflammation. J Leukoc Biol 62 (5): 620–633

    PubMed  CAS  Google Scholar 

  52. Alam R, York J, Boyars M et al (1996) Increased MCP-1, RANTES, and MIP-1a in bronchoalveolar lavage fluid of allergic asthmatic patients. Am J Crit Care Med 153: 1398–1404

    CAS  Google Scholar 

  53. Lamkhioued B, Renzi PM, Abi-Younes S et al (1997) Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation. J Immunol 159 (9): 4593–4601

    PubMed  CAS  Google Scholar 

  54. Berkman N, Krishnan VL, Gilbey T et al (1996) Expression of RANTES mRNA and protein in airways of patients with mild asthma. Am J Respir Crit Care Med 154 (6 Pt 1): 1804–1811

    PubMed  CAS  Google Scholar 

  55. Brown JR, Kleimberg J, Marini M, Sun G, Bellini A, Mattoli S (1998) Kinetics of eotaxin expression and its relationship to eosinophil accumulation and activation in bronchial biopsies and bronchoalveolar lavage (BAL) of asthmatic patients after allergen inhalation. Clin Exp Immunol 114 (2): 137–146

    Article  PubMed  CAS  Google Scholar 

  56. Mattoli S, Stacey MA, Sun G, Bellini A, Marini M (1997) Eotaxin expression and eosinophilic inflammation in asthma. Biochem Biophys Res Commun 236 (2): 299–301

    Article  PubMed  CAS  Google Scholar 

  57. Taha RA, Minshall EM, Miotto D et al (1999) Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals. J Allergy Clin Immunol 103 (3 Pt 1): 476–83

    Article  PubMed  CAS  Google Scholar 

  58. Ying S, Robinson DS, Meng Q et al (1997) Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol 27 (12): 3507–3516

    Article  PubMed  CAS  Google Scholar 

  59. Teruya-Feldstein J, Jaffe ES, Burd PR, Kingma DW, Setsuda JE, Tosato G (1999) Differential chemokine expression in tissues involved by Hodgkin’s disease: direct correlation of eotaxin expression and tissue eosinophilia. Blood 93 (8): 2463–2470

    PubMed  CAS  Google Scholar 

  60. Ghaffar O, Hamid Q, Renzi PM et al (1999) Constitutive and cytokine-stimulated expression of eotaxin by human airway smooth muscle cells. Am J Respir Crit Care Med 159 (6): 1933–1942

    PubMed  CAS  Google Scholar 

  61. John M, Hirst SJ, Jose PJ et al (1997) Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids. J Immunol 158 (4): 1841–1847

    PubMed  CAS  Google Scholar 

  62. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136 (7): 2348–2357

    PubMed  CAS  Google Scholar 

  63. Robinson DS, Hamid Q, Ying S et al (1992) Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 326 (5): 298–304

    Article  PubMed  CAS  Google Scholar 

  64. Li XM, Schofield BH, Wang QF, Kim KH, Huang SK (1998) Induction of pulmonary allergic responses by antigen-specific Th2 cells. J Immunol 160 (3): 1378–1384

    PubMed  CAS  Google Scholar 

  65. Li L, Xia Y, Nguyen A, Feng L, Lo D (1998) Th2-induced eotaxin expression and eosinophilia coexist with Th1 responses at the effector stage of lung inflammation. J Immunol 161 (6): 3128–3135

    PubMed  CAS  Google Scholar 

  66. Cohn L, Homer RJ, Marinov A, Rankin J, Bottomly K (1997) Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med 186 (10): 1737–1747

    Article  PubMed  CAS  Google Scholar 

  67. Li L, Xia Y, Nguyen A et al (1999) Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J Immunol 162 (5): 2477–2487

    PubMed  CAS  Google Scholar 

  68. Zhu Z, Homer RJ, Wang Z et al (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 103 (6): 779–788

    Article  PubMed  CAS  Google Scholar 

  69. Mochizuki M, Bartels J, Mallet AI, Christophers E, Schroder JM (1998) IL-4 induces eotaxin: a possible mechanism of selective eosinophil recruitment in helminth infection and atopy. J Immunol 160 (1): 60–68

    PubMed  CAS  Google Scholar 

  70. Teran LM, Mochizuki M, Bartels J et al (1999) Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts. Am J Respir Cell Mol Biol 20 (4): 777–786

    PubMed  CAS  Google Scholar 

  71. Bartels J, Schluter C, Richter E et al (1996) Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants. Biochem Biophys Res Commun 225 (3): 1045–1051

    Article  PubMed  CAS  Google Scholar 

  72. Clutterbuck EJ, Hirst EM, Sanderson CJ (1989) Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF. Blood 73 (6): 1504–1512

    PubMed  CAS  Google Scholar 

  73. Yamaguchi Y, Suda T, Ohta S, Tominaga K, Miura Y, Kasahara T (1991) Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. Blood 78 (10): 2542–2547

    PubMed  CAS  Google Scholar 

  74. Palframan RT, Collins PD, Severs NJ, Rothery S, Williams TJ, Rankin SM (1998) Mechanisms of acute eosinophil mobilisation from the bone marrow stimulated by interleukin-5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. J Exp Med 188 (9): 1621–1632

    Article  PubMed  CAS  Google Scholar 

  75. Palframan RT, Collins PD, Williams TJ, Rankin SM (1998) Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow. Blood 91 (7): 2240–2248

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Leukocyte Biology Section, Biomedical Science Division, Imperial College School of Medicine, Sir Alexander Fleming Building, London, SW7 2AZ, UK

    Tracey J. Mitchell & Timothy J. Williams

Authors
  1. Tracey J. Mitchell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Timothy J. Williams
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. NitroMed Inc., 12 Oak Park Drive, Bedford, MA, 01730, USA

    L. Gordon Letts

  2. Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL, 60064, USA

    Douglas W. Morgan

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer Basel AG

About this paper

Cite this paper

Mitchell, T.J., Williams, T.J. (2000). The role of eotaxin and related CC-chemokines in asthma and allergy. In: Letts, L.G., Morgan, D.W. (eds) Inflammatory Processes:. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8468-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-8468-6_1

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9580-4

  • Online ISBN: 978-3-0348-8468-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation