Skip to main content

Coexistence of angiotensin receptors and angiotensin in hypothalamic neurons of the rat

  • Chapter
The Peptidergic Neuron

Part of the book series: Advances in Life Sciences ((ALS))

Summary

By the use of immunocytochemical methods the colocalization of the octapeptide angiotensin II or fragments of it and the AT1 receptor subtype is shown in individual neurons of the paraventricular, the accessory and the supraoptic nucleus of the hypothalamus. Similar results were obtained with an anti-idiotypic antibody to angiotensin II antibodies. Our results provide strong evidence that angiotensin-containing hypothalamic neurons are innervated by angiotensinergic neurons.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • AmbĂĽhl, P., Felix, D., Imboden, H., Khosla, M.C. and Ferrario, C.M. (1992) Effects of angiotensin analogues and angiotensin receptor antagonists on paraventricular neurons. Regul. Peptides 38: 111–120.

    Article  Google Scholar 

  • Bunnemann, B., Fuxe, K. and Ganten, D. (1993) The renin-angiotensin system in the brain: an update 1993. Regul Peptides 46: 487–509.

    Article  CAS  Google Scholar 

  • Couraud, P.O. (1987) Anti-angiotensin II anti-idiotypic antibodies bind to angiotensin II receptor. J. Immunol. 138: 1164–1168.

    PubMed  CAS  Google Scholar 

  • Imboden, H., Harding, J.W., Abhold, R.H., Ganten, D. and Felix, D. (1987) Improved immunohistochemical staining of angiotensin II in rat brain using affinity purified antibodies. Brain Res. 426: 225–234.

    Article  PubMed  CAS  Google Scholar 

  • Imboden, H., Harding, J.W. and Felix, D. (1989) Hypothalamic angiotensinergic fibre systems terminate in the neurohypophysis. Neurosci. Lett. 96: 42–46.

    Article  PubMed  CAS  Google Scholar 

  • Imboden, H. and Felix, D. (1991) An immunocytochemical comparison of the angiotensin and vasopressin hypothalamo-neurohypophysial systems in normotensive rats. Regul. Peptides 36: 197–218.

    Article  CAS  Google Scholar 

  • Imboden, H. and Felix, D. (1995) Immunocytochemistry in Brain Tissue. In: M.I. Phillips and D. Evans (eds.): Methods in Neurosciences Volume 24, Neuroimmunology, Academic Press, London, pp. 236–260.

    Google Scholar 

  • Pfister, J., Felix, D. and Imboden, H. (1993) Immunohistochemical demonstration of angiotensin II receptors in rat brain by use of an anti-idiotypic antibody. Regul. Peptides 44: 109–117.

    Article  CAS  Google Scholar 

  • Lind, R.W., Swanson, L.W. and Ganten, D. (1985) Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. Neuroendocrinology 40: 2–24.

    Article  PubMed  CAS  Google Scholar 

  • Phillips, M.I., Shen, L., Richards, E.M. and Raizada, M.K. (1993) Immunhistochemical mapping of angiotensin AT1 receptors in the brain. Regul. Peptides 44: 95–107.

    Article  CAS  Google Scholar 

  • Saavedra, J.M. (1992) Brain and pituitary angiotensin. Endocrine Reviews 13 (2): 329–380.

    PubMed  CAS  Google Scholar 

  • Tsutsumi, K. and Saavedra, J.M. (1991) Differential development of angiotensin II receptor subtypes in the rat brain. Endocrinology 128: 630–632.

    Article  PubMed  CAS  Google Scholar 

  • Wright, J.W. and Harding, J.W. (1994). Brain angiotensin receptor subtypes in the control of physiological and behavioural responses. Neuroscience and Biobehavioural Reviews 18: 21–53.

    Article  CAS  Google Scholar 

  • Zelezna, B., Richards, E.M., Tang, W., Lu, D., Sumners, C. and Raizada, M.K. (1992) Characterization of a polyclonal antipeptide antibody to the angiotensin II type-1 (AT1) receptor. Biochem. Biophys. Res. Commun. 183: 781–788.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Spengler, C., Pfister, J., Mosimann, R., Raizada, M., Felix, D., Imboden, H. (1996). Coexistence of angiotensin receptors and angiotensin in hypothalamic neurons of the rat. In: Krisch, B., Mentlein, R. (eds) The Peptidergic Neuron. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9010-6_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-9010-6_16

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9866-9

  • Online ISBN: 978-3-0348-9010-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics