Summary
By the use of immunocytochemical methods the colocalization of the octapeptide angiotensin II or fragments of it and the AT1 receptor subtype is shown in individual neurons of the paraventricular, the accessory and the supraoptic nucleus of the hypothalamus. Similar results were obtained with an anti-idiotypic antibody to angiotensin II antibodies. Our results provide strong evidence that angiotensin-containing hypothalamic neurons are innervated by angiotensinergic neurons.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ambühl, P., Felix, D., Imboden, H., Khosla, M.C. and Ferrario, C.M. (1992) Effects of angiotensin analogues and angiotensin receptor antagonists on paraventricular neurons. Regul. Peptides 38: 111–120.
Bunnemann, B., Fuxe, K. and Ganten, D. (1993) The renin-angiotensin system in the brain: an update 1993. Regul Peptides 46: 487–509.
Couraud, P.O. (1987) Anti-angiotensin II anti-idiotypic antibodies bind to angiotensin II receptor. J. Immunol. 138: 1164–1168.
Imboden, H., Harding, J.W., Abhold, R.H., Ganten, D. and Felix, D. (1987) Improved immunohistochemical staining of angiotensin II in rat brain using affinity purified antibodies. Brain Res. 426: 225–234.
Imboden, H., Harding, J.W. and Felix, D. (1989) Hypothalamic angiotensinergic fibre systems terminate in the neurohypophysis. Neurosci. Lett. 96: 42–46.
Imboden, H. and Felix, D. (1991) An immunocytochemical comparison of the angiotensin and vasopressin hypothalamo-neurohypophysial systems in normotensive rats. Regul. Peptides 36: 197–218.
Imboden, H. and Felix, D. (1995) Immunocytochemistry in Brain Tissue. In: M.I. Phillips and D. Evans (eds.): Methods in Neurosciences Volume 24, Neuroimmunology, Academic Press, London, pp. 236–260.
Pfister, J., Felix, D. and Imboden, H. (1993) Immunohistochemical demonstration of angiotensin II receptors in rat brain by use of an anti-idiotypic antibody. Regul. Peptides 44: 109–117.
Lind, R.W., Swanson, L.W. and Ganten, D. (1985) Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. Neuroendocrinology 40: 2–24.
Phillips, M.I., Shen, L., Richards, E.M. and Raizada, M.K. (1993) Immunhistochemical mapping of angiotensin AT1 receptors in the brain. Regul. Peptides 44: 95–107.
Saavedra, J.M. (1992) Brain and pituitary angiotensin. Endocrine Reviews 13 (2): 329–380.
Tsutsumi, K. and Saavedra, J.M. (1991) Differential development of angiotensin II receptor subtypes in the rat brain. Endocrinology 128: 630–632.
Wright, J.W. and Harding, J.W. (1994). Brain angiotensin receptor subtypes in the control of physiological and behavioural responses. Neuroscience and Biobehavioural Reviews 18: 21–53.
Zelezna, B., Richards, E.M., Tang, W., Lu, D., Sumners, C. and Raizada, M.K. (1992) Characterization of a polyclonal antipeptide antibody to the angiotensin II type-1 (AT1) receptor. Biochem. Biophys. Res. Commun. 183: 781–788.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Birkhäuser Verlag Basel/Switzerland
About this chapter
Cite this chapter
Spengler, C., Pfister, J., Mosimann, R., Raizada, M., Felix, D., Imboden, H. (1996). Coexistence of angiotensin receptors and angiotensin in hypothalamic neurons of the rat. In: Krisch, B., Mentlein, R. (eds) The Peptidergic Neuron. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9010-6_16
Download citation
DOI: https://doi.org/10.1007/978-3-0348-9010-6_16
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-9866-9
Online ISBN: 978-3-0348-9010-6
eBook Packages: Springer Book Archive