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Roles for hsp70 in protein translocation across membranes of organelles

  • Chapter
Stress-Inducible Cellular Responses

Part of the book series: EXS ((EXS,volume 77))

Summary

The family of hsp70 molecular chaperones plays an essential and diverse role in cellular physiology. Hsp70 proteins appear to elicit their effects by interaction with polypeptides that present domains which exhibit non-native conformations at distinct stages during their life in the cell. Work pertaining to the functions of hsp70 proteins in driving protein translocation across membranes is reviewed herein. Hsp70 proteins function to deliver polypeptides to protein translocation channels, unfold polypeptides during transit across membranes and drive the translocation process. All these reactions are facilitated in an ATP-dependent reaction cycle with the assistance of different partner proteins that modulate the function of hsp70.

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Authors and Affiliations

  1. Department of Cell Biology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294-0005, USA

    D. M. Cyr

  2. Institut für Physiologische Chemie der Universität München, Goethestrasse 33, D-80336, München, Germany

    W. Neupert

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  1. D. M. Cyr
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Editors and Affiliations

  1. Department of Pharmacology, AMGEN Center, 1840 De Havilland Drive, 15-2-A-224, 91320-1789, Thousand Oaks, CA, USA

    U. Feige

  2. Department of Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-Ku, Tokyo 113, Japan

    I. Yahara

  3. Department of Biochemistry, Molecular and Cell Biology Northwestern University, 2153 Sheridan Road, 60208-3500, Evanston, IL, USA

    R. I. Morimoto

  4. Laboratoire de Physiologie Respiratoire, Université Paris 5 UFR Cochin Port-Royal, 24, rue du Faubourg Saint-Jacques, F-75014, Paris, France

    B. S. Polla

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Cyr, D.M., Neupert, W. (1996). Roles for hsp70 in protein translocation across membranes of organelles. In: Feige, U., Yahara, I., Morimoto, R.I., Polla, B.S. (eds) Stress-Inducible Cellular Responses. EXS, vol 77. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9088-5_3

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  • DOI: https://doi.org/10.1007/978-3-0348-9088-5_3

  • Publisher Name: Birkhäuser Basel

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