Abstract
The release of acetylcholine from central and peripheral neurones can be inhibited and facilitated by muscarine autoreceptors, i.e. receptors located on the cholinergic neurone. In the last few years evidence has accumulated that muscarine receptors are heterogeneous. This chapter describes attempts that have been made to classify the muscarine autoreceptors. In addition, some possible mechanisms behind the neuronal muscarine receptors are examined.
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References
Barlow, R. B., Berry, K. J., Glenton, P. A. M., Nikolaou, N. M., and Soh, K. S. (1976) A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea- pig atrial pacemaker cells at 29°C and in ileum at 29°C and 37°C. Br. J. Pharmac. 58: 613 – 620.
Birdsall, N. J. M., and Hulme, E. C. (1985) Multiple muscarinic receptors: further problems in receptor classification. In: Kalsner, S. (ed.), Trends in autonomic pharmacology, vol. 3, pp. 17 – 34. Taylor and Francis, London.
Dolphin, A. C. (1987) Nucleotide binding proteins in signal transduction and disease. TINS 10: 53 – 57.
Dunant, Y., and Walker, A. I. (1982) Cholinergic inhibition of acetylcholine release in the electric organ of Torpedo. Eur. J. Pharmac. 78: 201 – 212.
Fuder, H., Kilbinger, H., and M’ller, H. (1985) Organ selectivity of hexahydrosiladifenidol in blocking pre- and postjunctional muscarinic receptors studied in guinea-pig ileum and rat heart. Eur. J. Pharmac. 113: 125 – 127.
Giachetti, A., Micheletti, R., and Montagna, E. (1986) Cardioselective profile of AF-DX 116, a muscarine M2 receptor antagonist. Life Sci. 38; 1663 – 1672.
James, M. K., and Cubeddu, L. X. (1987) Pharmacologic characterization and functional role of muscarinic autoreceptors in the rabbit striatum. J. Pharmac. Ther. 240: 203 – 215.
Jeck, D., Lindmar, R., Löffelholz, K., and Wanke, M. (1988) Subtypes of muscarinic receptor on cholinergic nerves and atrial cells of chicken and guinea-pig hearts. Br. J. Pharmac. 93: 357 – 366.
Kawashima, K., Fujimoto, K., Suzuki, T., and Oohata, H. (1988) Direct determination of acetylcholine release by radioimmunoassay and presence of presynaptic M1 muscarinic receptors in guinea pig ileum. J. Pharmac. exp. Ther. 244: 1036 – 1039.
Kilbinger, H. (1977) Modulation by oxotremorine and atropine of acetylcholine relase evoked by electrical stimulation of the myenteric plexus of the guinea-pig ileum. Nauyn-Schmiedeberg’s Arch. Pharmak. 300: 145 – 151.
Kilbinger, H. (1978) Muscarinic modulation of acetylcholine release from the myenteric plexus of the guinea pig small intestine. In: Jenden, D. J. (ed.), Cholinergic Mechanism and Psychopharmacology, pp. 401 – 410. Plenum Press, New York.
Kilbinger, H. (1987) Control of acetylcholine release by muscarinic autoreceptors. In: Cohen, S., and Sokolovsky, M. (eds), International Symposium on Muscarinic Cholinergic Mechanisms, pp. 219 – 228. Freund Publ House, London.
Kilbinger, H., Halim, S., Lambrecht, G., Weiler, W., and Wessler, I. (1984) Comparison of affinities of muscarinic antagonists to pre- and postjunctional receptors in the guinea-pig ileum. Eur. J. Pharmac. 103: 313 – 320.
Kilbinger, H., and Nafziger, M. (1985) Two types of neuronal muscarine receptors modulating acetylcholine release from guinea-pig myenteric plexus. Naunyn-Schmiedeberg’s Arch. Pharmak. 328: 304 – 309.
Kilbinger, H., and Stein, A. (1988) Dicyclomine discriminates between Ml and M2 muscarinic receptors in the guinea-pig ileum. Br. J. Pharmac. 94: 1270 – 1274.
Lux, B., and Schulz, R. (1986) Effect of cholera toxin and pertussis toxin on opioid tolerance and dependence in the guinea-pig myenteric plexus. J. Pharmac. exp. Ther. 237; 995 – 1000.
Marchi, M., and Raiteri, M. (1985) On the presence in the cerebral cortex of muscarinic receptor subtypes which differ in neuronal localization, function and pharmacological properties. J. Pharmac. exp. Ther. 235: 230 – 233.
McKinney, M., and Richelson, E. (1984) The coupling of the neuronal muscarinic receptor to responses. A. Rev. Pharmac. Toxic. 24: 121 – 146.
Melchiorre, C., Cassinelli, A., and Quaglia, W. (1987) Differential blockade of muscarinic receptor subtypes by polymethylene tetraamines. Novel class of selective antagonists of cardiac M2 muscarinic receptors. J. med. Chem. 30: 201 – 204.
Mutschler, E., and Lambrecht, G. (1984) Selective muscarinic agonists and antagonists in functional tests. Trends pharmac. Sci. 5: Suppl, 39 – 44.
North, R., Slack, B. E., and Surprenant, A. (1985) Muscarinic Ml and M2 receptors mediate depolarization and presynaptic inhibition in guinea-pig enteric nervous system. J. Physiol. 368: 435 – 452.
Roberts, E., and Tutty, C. (1986) Quantification of the effects of muscarinic antagonists on the release of [3H] acetylcholine from rat cerebral cortex slices. Br. J. Pharmac. 88: 358 P.
Schwarzwälder, U., Johann, S., and Melchiorre, C. (1988) Subtypes of muscarinic autoreceptors in rabbit hippocampus and caudate nucleus. Naunyn-Schmiedeberg’s Arch Pharmak. 337: R 89.
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© 1989 Birkhäuser Verlag
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Kilbinger, H., Schwörer, H., Süß, K.D. (1989). Muscarinic modulation of acetylcholine release: Receptor subtypes and possible mechanisms. In: Frotscher, M., Misgeld, U. (eds) Central Cholinergic Synaptic Transmission. Experientia Supplementum, vol 57. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9138-7_20
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DOI: https://doi.org/10.1007/978-3-0348-9138-7_20
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-9922-2
Online ISBN: 978-3-0348-9138-7
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