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Annotating bacterial genomes

  • Chapter
Modern Genome Annotation

Abstract

Since the mid-eighties, laboratories world-wide have endeavoured to determine the complete sequence of genomes from all kinds of living organisms. The first complete sequence of DNA bacteriophage ΦX174 appeared in 1978 (5386 nt (Sanger et al. 1978)), followed by that of bacteriophage lambda, using a shotgun technology, published in 1982 (48,502 bp) (Sanger et al. 1982) and that of a short bacterial genome (Haemophilus influenzae 1,830,138 bp, using a scaling up of the same shotgun technique) was published in 1995 (Smith et al. 1995). Curiously, while enormous amounts of funding were involved in sequencing, only comparatively small effort and support has been devoted to the creation of high-quality genome annotations, in particular in the creation of the very important link between experimental validation of in silico (Danchin et al. 1991) predictions and annotations. Indeed, explicit reference to experimental validation of annotation has only been recently introduced at the International Nucleotide Sequence Database Collaboration (INSDC http://www. insdc.org/).

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Authors and Affiliations

  1. Génomique Métabolique, CNRS UMR8030, Evry Cedex, France

    C. Médigue

  2. Genoscope, Laboratoire de Génomique Comparative, Commissariat à l’Energie Atomique (CEA), Direction des Sciences du Vivant, Institut de Génomique, Evry Cedex, France

    C. Médigue

  3. Département Génomes et Génétique, Institut Pasteur, Génétique des Génomes Bactériens, URA2171 CNRS, 28 rue du Docteur Roux, 75724, Paris Cedex 15, France

    A. Danchin

Authors
  1. C. Médigue
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  2. A. Danchin
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Correspondence to A. Danchin .

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Editors and Affiliations

  1. Wissenschaftszentrum Weihenstephan, TU München, Freising, Germany

    Dmitrij Frishman

  2. Structural and Computational Programme, Spanish National Cancer Research Centre, Madrid, Spain

    Alfonso Valencia

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© 2008 Springer-Verlag/Wien

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Médigue, C., Danchin, A. (2008). Annotating bacterial genomes. In: Frishman, D., Valencia, A. (eds) Modern Genome Annotation. Springer, Vienna. https://doi.org/10.1007/978-3-211-75123-7_9

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