Skip to main content
SpringerLink
Log in

Regeneration und Zelltod von Sinneszellen der Cochlea und des Vestibularorgans

  • Conference paper
Der Gleichgewichtssinn

  • 933 Accesses

Zusammenfassung

Das Innenohr kann in drei Bereiche unterteilt werden: (1) Cochlea mit Corti-Organ, (2) Gleichgewichtsorgan mit Bogengangssystem und Crista ampularis sowie (3) Sacculus und Utriculus. In allen drei Bereichen befinden sich Sinneszellen (Haarzellen) und Stützzellen. Die Sinneszellen der menschlichen Cochlea unterteilen sich in ca. 12.000 äußere Haarzellen (ÄHZ) und ca. 3600 innere Haarzellen (IHZ) (Naumann et al. 1994). Die ÄHZ sind in drei Reihen und die IHZ in einer Reihe angeordnet. Sowohl IHZ als auch ÄHZ haben Stereozilien. Die Besonderheit der ÄHZ ist, dass sie sich durch das Motorprotein Prestin kontrahieren bzw. elongieren können. Zu den Stützzellen der Cochlea gehören die Deiters-Zellen, Hensen-Zellen, Pfeilerzellen, Phalangenzellen, Interdental-Zellen und Innere Sulkuszellen. Die Stützzellen spielen für die Regeneration eine bedeutende Rolle.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 89.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Andreeva N, Nyamaa A, Haupt H, Gross J, Mazurek B (2006) Recombinant human erythropoietin prevents ischemia-induced apoptosis and necrosis in explant cultures of the rat organ of Corti. Neurosci Lett 396: 86–90

    Article  CAS  PubMed  Google Scholar 

  • Ashe PC, Berry MD (2003) Apoptotic signaling cascades. Prog Neuropsychopharmacol Biol Psychiatry 27: 199–214

    Article  CAS  PubMed  Google Scholar 

  • Atar O, Avraham KB (2005) Therapeutics of hearing loss: expectations vs reality. Drug Discov Today 10: 1323–1330

    Article  PubMed  Google Scholar 

  • Baldassarre G, Boccia A, Bruni P, Sandomenico C, Barone MV, Pepe S, Angrisano T, Belletti B, Motti ML, Fusco A, Viglietto G (2000) Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27. Cell Growth Differ 11: 517–526

    CAS  PubMed  Google Scholar 

  • Bermingham NA, Hassan BA, Price SD, Vollrath MA, Ben Arie N, Eatock RA, Bellen HJ, Lysakowski A, Zoghbi HY (1999) Math 1: an essential gene for the generation of inner ear hair cells. Science 284: 1837–1841

    Article  CAS  PubMed  Google Scholar 

  • Bjorklund LM, Sanchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O (2002) Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A 99: 2344–2349

    Article  CAS  PubMed  Google Scholar 

  • Cande C, Cecconi F, Dessen P, Kroemer G (2002) Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci 115: 4727–4734

    Article  CAS  PubMed  Google Scholar 

  • Chen M, Wang J (2002) Initiator caspases in apoptosis signaling pathways. Apoptosis 7: 313–319

    Article  CAS  PubMed  Google Scholar 

  • Chen P, Segil N (1999) p27 (Kip 1) links cell proliferation to morphogenesis in the developing organ of Corti. Development 126: 1581–1590

    CAS  PubMed  Google Scholar 

  • Chen P, Zindy F, Abdala C, Liu F, Li X, Roussel MF, Segil N (2003) Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nat Cell Biol 5: 422–426

    Article  CAS  PubMed  Google Scholar 

  • Corwin JT, Cotanche DA (1988) Regeneration of sensory hair cells after acoustic trauma. Science 240: 1772–1774

    Article  CAS  PubMed  Google Scholar 

  • Cotanche DA (1987) Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma. Hear Res 30: 181–195

    Article  CAS  PubMed  Google Scholar 

  • Cunningham LL, Matsui JI, Warchol ME, Rubel EW (2004) Overexpression of Bcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utricle in vitro. J Neurobiol 60: 89–100

    Article  CAS  PubMed  Google Scholar 

  • Davis RJ (2000) Signal transduction by the JNK group of MAP kinases. Cell 103: 239–252

    Article  CAS  PubMed  Google Scholar 

  • Duan M, Venail F, Spencer N, Mezzina M (2004) Treatment of peripheral sensorineural hearing loss: gene therapy. Gene Ther 11 Suppl 1: S51–S56

    Article  CAS  PubMed  Google Scholar 

  • Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM (1996) A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 85: 733–744

    Article  CAS  PubMed  Google Scholar 

  • Forge A, Li L (2000) Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hear Res 139: 97–115

    Article  CAS  PubMed  Google Scholar 

  • Forge A, Li L, Nevill G (1998) Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs. J Comp Neurol 397: 69–88

    Article  CAS  PubMed  Google Scholar 

  • Holley MC (2005) Keynote review: The auditory system, hearing loss and potential targets for drug development. Drug Discov Today 10: 1269–1282

    Article  CAS  PubMed  Google Scholar 

  • Holt JR (2002) Viral-mediated gene transfer to study the molecular physiology of the Mammalian inner ear. Audiol Neurootol 7: 157–160

    Article  CAS  PubMed  Google Scholar 

  • Hu BH, Guo W, Wang PY, Henderson D, Jiang SC (2000) Intense noise-induced apoptosis in hair cells of guinea pig cochleae. Acta Otolaryngol 120: 19–24

    Article  CAS  PubMed  Google Scholar 

  • Hu Z, Wei D, Johansson CB, Holmstrom N, Duan M, Frisen J, Ulfendahl M (2005) Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear. Exp Cell Res 302: 40–47

    Article  CAS  PubMed  Google Scholar 

  • Ito J, Kojima K, Kawaguchi S (2001) Survival of neural stem cells in the cochlea. Acta Otolaryngol 121: 140–142

    Article  CAS  PubMed  Google Scholar 

  • Izumikawa M, Minoda R, Kawamoto K, Abrashkin KA, Swiderski DL, Dolan DF, Brough DE, Raphael Y (2005) Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nat Med 11: 271–276

    Article  CAS  PubMed  Google Scholar 

  • Jones JM, Montcouquiol M, Dabdoub A, Woods C, Kelley MW (2006) Inhibitors of differentiation and DNA binding (Ids) regulate Math 1 and hair cell formation during the development of the organ of Corti. J Neurosci 26: 550–558

    Article  CAS  PubMed  Google Scholar 

  • Jorgensen JM, Mathiesen C (1988) The avian inner ear. Continuous production of hair cells in vestibular sensory organs, but not in the auditory papilla. Naturwissenschaften 75: 319–320

    Article  CAS  PubMed  Google Scholar 

  • Kanzaki S, Beyer LA, Swiderski DL, Izumikawa M, Stover T, Kawamoto K, Raphael Y (2006) p27(Kip1) deficiency causes organ of Corti pathology and hearing loss. Hear Res 214: 28–36

    Article  CAS  PubMed  Google Scholar 

  • Kawamoto K, Ishimoto S, Minoda R, Brough DE, Raphael Y (2003) Math1 gene transfer generates new, cochlear hair cells in mature guinea pigs in vivo. J Neurosci 23: 4395–4400

    CAS  PubMed  Google Scholar 

  • Kawamoto K, Sha SH, Minoda R, Izumikawa M, Kuriyama H, Schacht J, Raphael Y (2004) Antioxidant gene therapy can protect hearing and hair cells from ototoxicity. Mol Ther 9: 173–181

    Article  CAS  PubMed  Google Scholar 

  • Kelley MW (2006) Regulation of cell fate in the sensory epithelia of the inner ear. Nat Rev Neurosci 7: 837–849

    Article  CAS  PubMed  Google Scholar 

  • Kil J, Warchol ME, Corwin JT (1997) Cell death, cell proliferation, and estimates of hair cell life spans in the vestibular organs of chicks. Hear Res 114: 117–126

    Article  CAS  PubMed  Google Scholar 

  • Lefebvre PP, Malgrange B, Lallemend F, Staecker H, Moonen G, Van De Water TR (2002) Mechanisms of cell death in the injured auditory system: otoprotective strategies. Audiol Neurootol 7: 165–170

    Article  CAS  PubMed  Google Scholar 

  • Li H, Liu H, Heller S (2003a) Pluripotent stem cells from the adult mouse inner ear. Nat Med 9: 1293–1299

    Article  CAS  PubMed  Google Scholar 

  • Li H, Roblin G, Liu H, Heller S (2003b) Generation of hair cells by stepwise differentiation of embryonic stem cells. Proc Natl Acad Sci U S A 100: 13495–13500

    Article  CAS  PubMed  Google Scholar 

  • Li L, Forge A (1997) Morphological evidence for supporting cell to hair cell conversion in the mammalian utricular macula. Int J Dev Neurosci 15: 433–446

    Article  CAS  PubMed  Google Scholar 

  • Löwenheim H (2002) Grundlagen der In-vivo-Regeneration im Kopf-Hals-Bereich. Laryngorhinootologie 81 Suppl 1: 1–23

    Article  Google Scholar 

  • Löwenheim H (2003) Regenerative medicine for diseases of the head and neck: principles of in vivo regeneration. DNA Cell Biol 22: 571–592

    Article  PubMed  Google Scholar 

  • Löwenheim H, Furness DN, Kil J, Zinn C, Gultig K, Fero ML, Frost D, Gummer AW, Roberts JM, Rubel EW, Hackney CM, Zenner HP (1999) Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti. Proc Natl Acad Sci U S A 96: 4084–4088

    Article  PubMed  Google Scholar 

  • Maiorana CR, Staecker H (2005) Advances in inner ear gene therapy: exploring cochlear protection and regeneration. Curr Opin Otolaryngol Head Neck Surg 13: 308–312

    Article  PubMed  Google Scholar 

  • Majno G, Joris I (1995) Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146: 3–15

    CAS  PubMed  Google Scholar 

  • Matsui JI, Cotanche DA (2004) Sensory hair cell death and regeneration: two halves of the same equation. Curr Opin Otolaryngol Head Neck Surg 12: 418–425

    PubMed  Google Scholar 

  • Matsui JI, Haque A, Huss D, Messana EP, Alosi JA, Roberson DW, Cotanche DA, Dickman JD, Warchol ME (2003) Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo. J Neurosci 23: 6111–6122

    CAS  PubMed  Google Scholar 

  • Matsui JI, Parker MA, Ryals BM, Cotanche DA (2005) Regeneration and replacement in the vertebrate inner ear. Drug Discov Today 10: 1307–1312

    Article  PubMed  Google Scholar 

  • Minoda R, Izumikawa M, Kawamoto K, Raphael Y (2004) Strategies for replacing lost cochlear hair cells. Neuroreport 15: 1089–1092

    Article  PubMed  Google Scholar 

  • Naumann HH, Helms J, Herberhold C, Kastenbauer E (1994) Oto-Rhinolaryngologie in Klinik und Praxis. Band 1 Ohr. Thieme, Stuttgart

    Google Scholar 

  • Nicotera TM, Henderson D, Hu BH, Zheng XY (2001) Noise exposure and mechanisms of hair cell death. In: Henderson D, Prasher D, Kopke R, Salvi R, Hamernik R (Hrsg) Noise induced hearing loss: basic mechanisms, prevention and control. Noise research Network Publications, London S 99–117

    Google Scholar 

  • Nicotera TM, Hu BH, Henderson D (2003) The caspase pathway in noise-induced apoptosis of the chinchilla cochlea. J Assoc Res Otolaryngol 4: 466–477

    Article  PubMed  Google Scholar 

  • Oshima K, Heller S (2005) Sound from silence. Nat Med 11: 249–250

    Article  CAS  PubMed  Google Scholar 

  • Parker MA, Cotanche DA (2004) The potential use of stem cells for cochlear repair. Audiol Neurootol 9: 72–80

    Article  PubMed  Google Scholar 

  • Pirvola U, Xing-Qun L, Virkkala J, Saarma M, Murakata C, Camoratto AM, Walton KM, Ylikoski J (2000) Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci 20: 43–50

    CAS  PubMed  Google Scholar 

  • Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA (2003) Insulin staining of ES cell progeny from insulin uptake. Science 299: 363

    PubMed  Google Scholar 

  • Raphael Y (2002) Cochlear pathology, sensory cell death and regeneration. Br Med Bull 63: 25–38

    Article  CAS  PubMed  Google Scholar 

  • Sage C, Huang M, Karimi K, Gutierrez G, Vollrath MA, Zhang DS, Garcia-Anoveros J, Hinds PW, Corwin JT, Corey DP, Chen ZY (2005) Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science 307: 1114–1118

    Article  CAS  PubMed  Google Scholar 

  • Sasaki K, Tamura S, Tachibana H, Sugita M, Gao Y, Furuyama J, Kakishita E, Sakai T, Tamaoki T, Hashimoto-Tamaoki T (2000) Expression and role of p27(kip1) in neuronal differentiation of embryonal carcinoma cells. Brain Res Mol Brain Res 77: 209–221

    Article  CAS  PubMed  Google Scholar 

  • Tateya I, Nakagawa T, Iguchi F, Kim TS, Endo T, Yamada S, Kageyama R, Naito Y, Ito J (2003) Fate of neural stem cells grafted into injured inner ears of mice. Neuroreport 14: 1677–1681

    Article  PubMed  Google Scholar 

  • Taylor R, Forge A (2005) Developmental biology. Life after deaf for hair cells? Science 307: 1056–1058

    Article  CAS  PubMed  Google Scholar 

  • Van De Water TR, Lallemend F, Eshraghi AA, Ahsan S, He J, Guzman J, Polak M, Malgrange B, Lefebvre PP, Staecker H, Balkany TJ (2004) Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells. Otol Neurotol 25: 627–632

    Article  Google Scholar 

  • Walshe P, Walsh M, McConn WR (2003) Hair cell regeneration in the inner ear: a review. Clin Otolaryngol 28: 5–13

    Article  CAS  PubMed  Google Scholar 

  • Wang J, Van De Water TR, Bonny C, de Ribaupierre F, Puel JL, Zine A (2003) A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci 23: 8596–8607

    CAS  PubMed  Google Scholar 

  • Warchol ME, Lambert PR, Goldstein BJ, Forge A, Corwin JT (1993) Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. Science 259: 1619–1622

    Article  CAS  PubMed  Google Scholar 

  • Yamasoba T, Kondo K (2006) Supporting cell proliferation after hair cell injury in mature guinea pig cochlea in vivo. Cell Tissue Res 325: 23–31

    Article  PubMed  Google Scholar 

  • Ylikoski J, Xing-Qun L, Virkkala J, Pirvola U (2002) Blockade of c-Jun N-terminal kinase pathway aften-uates gentamicin-induced cochlear and vestibular hair cell death. Hear Res 163: 71–81

    Article  CAS  PubMed  Google Scholar 

  • Zheng JL, Frantz G, Lewis AK, Sliwkowski M, Gao WQ (1999) Heregulin enhances regenerative proliferation in postnatal rat utricular sensory epithelium after otoxic damage. J Neurocytol 28: 901–912

    Article  CAS  PubMed  Google Scholar 

  • Zheng JL, Shou J, Guillemot F, Kageyama R, Gao WQ (2000) Hes1 is a negative regulator of inner ear hair cell differentiation. Development 127: 4551–4560

    CAS  PubMed  Google Scholar 

  • Zine A, Aubert A, Qiu J, Therianos S, Guillemot F, Kageyama R, de Ribaupierre F (2001) Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear. J Neurosci 21: 4712–4720

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. HNO-Klinik der Charité Berlin, Campus Mitte, Charitéplatz 1, 10115, Berlin, Deutschland

    PD Dr. med. Birgit Mazurek (Leiterin des Tinnituszentrums)

Authors
  1. PD Dr. med. Birgit Mazurek
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Haupt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Szczepek
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Berlin, Deutschland

    Hans Scherer (Direktor der HNO Khniken der Charité) (Direktor der HNO Khniken der Charité)

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag/Wien

About this paper

Cite this paper

Mazurek, B., Haupt, H., Szczepek, A. (2008). Regeneration und Zelltod von Sinneszellen der Cochlea und des Vestibularorgans. In: Scherer, H. (eds) Der Gleichgewichtssinn. Springer, Vienna. https://doi.org/10.1007/978-3-211-75432-0_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-211-75432-0_21

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-75431-3

  • Online ISBN: 978-3-211-75432-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation