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The Impact of Computational Fluid Mechanics on Cancer Research

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Computational and Experimental Fluid Mechanics with Applications to Physics, Engineering and the Environment

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Abstract

This chapter presents an overview of recent contributions that show how fluid mechanics is drastically changing cancer research. The review will mainly focus on the computational modelling of fluid-mediated processes related to cancer dynamics, spanning different representation scales from cells to organs. Fluid mechanics seems to act as a fundamental organizing principle in many aspects of cancer, including its growth, progression, metastasis, and therapy. On the other hand, it is clear that fluid-dynamics modelling can make a huge contribution to many areas of experimental cancer investigation since there is now a wealth of data that requires systematic analysis. The relevance of microfluidics in the isolation, detection, molecular characterization, and migration of tumour cells is also discussed. In the last part of the chapter, future challenges and perspectives are briefly outlined.

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Acknowledgments

D. C. Belisario acknowledges the organizers of the I Workshop of the Venezuelan Society of Fluid Mechanics for inviting me to write part of this chapter.

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Authors and Affiliations

  1. Dipartimento di Oncologia, Università degli Studi di Torino, Via Santena 5/BIS, 10126, Torino, Italy

    Dimas C. Belisario

  2. Centro de Física, Instituto Venezolano de Investigaciones Científicas, IVIC, Apartado 20632, Caracas, 1020-A, Venezuela

    Leonardo Di. G. Sigalotti

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  1. Dimas C. Belisario
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Correspondence to Dimas C. Belisario .

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  1. Centro de Física, Instituto Venezolano de Investigaciones Científicas, San Antonio de Los Altos, Miranda, Venezuela

    Leonardo Di G. Sigalotti

  2. Instituto Nacional de Investigaciones Nucleares and Cinvestav-Abacus, La Marquesa, Estado de México, Mexico

    Jaime Klapp

  3. Centro de Física, Instituto Venezolano de Investigaciones Científicas, San Antonio de Los Altos, Miranda, Venezuela

    Eloy Sira

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Belisario, D.C., Sigalotti, L.D.G. (2014). The Impact of Computational Fluid Mechanics on Cancer Research. In: Sigalotti, L., Klapp, J., Sira, E. (eds) Computational and Experimental Fluid Mechanics with Applications to Physics, Engineering and the Environment. Environmental Science and Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-00191-3_6

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