Skip to main content

Clear Cell Carcinoma

  • Chapter
  • First Online:
Atlas of Salivary Gland Pathology
  • 1640 Accesses

Abstract

Clear cell carcinoma affects primarily adults and presents at a mean age of approximately 60 years. Women are involved more than men. The majority of cases involve minor salivary glands in the oral cavity, presenting as single or multiple masses. Most cases of clear cell carcinoma behave as low-grade malignancies. Clear cell carcinoma is infiltrative, comprised of one cell type (ductal), and may exhibit a variety of architectural patterns (single cells, nests, trabeculae, and solid) with or without hyalinized stroma (Figs. 12.1, 12.2, 12.3, 12.4, 12.5, 12.6, 12.7, 12.8, 12.9, 12.10, 12.11, 12.12, 12.13, 12.14, 12.15, 12.16, 12.17, 12.18, 12.19 and 12.20).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Suggested Reading

  • Antonescu CR, Katabi N, Zhang L, Sung YS, Seethala RR, Jordan RC, et al. EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer. 2011;50(7):559–70.

    Article  CAS  Google Scholar 

  • Jin R, Craddock KJ, Irish JC, Perez-Ordonez B, Weinreb I. Recurrent hyalinizing clear cell carcinoma of the base of tongue with high-grade transformation and EWSR1 gene rearrangement by FISH. Head Neck Pathol. 2012;6(3):389–94.

    Article  Google Scholar 

  • Lai G, Nemolato S, Lecca S, Parodo G, Medda C, Faa G. The role of immunohistochemistry in the diagnosis of hyalinizing clear cell carcinoma of the minor salivary gland: a case report. Eur J Histochem. 2008;52:251–4.

    Article  CAS  Google Scholar 

  • Milchgrub S, Gnepp DR, Vuitch F, Delgado R, Albores-Saavedra J. Hyalinizing clear cell carcinoma of salivary gland. Am J Surg Pathol. 1994;18(1):74–82.

    Article  CAS  Google Scholar 

  • Milchgrub S, Vuitch F, Saboorian MH, Hameed A, Wu H, Albores-Saavedra J. Hyalinizing clear-cell carcinoma of salivary glands in fine-needle aspiration. Diagn Cytopathol. 2000;23(5):333–7.

    Article  CAS  Google Scholar 

  • O’Sullivan-Mejia ED, Massey HD, Faquin WC, Powers CN. Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. Head Neck Pathol. 2009;3:179–85.

    Article  Google Scholar 

  • Shah AA, LeGallo RD, van Zante A, Frierson HF Jr, Mills SE, Berean KW, et al. EWSR1 genetic rearrangements in salivary gland tumors: a specific and very common feature of hyalinizing clear cell carcinoma. Am J Surg Pathol. 2013;37(4):571–8.

    Article  Google Scholar 

  • Simpson RH, Sarsfield PT, Clarke T, Babajews AV. Clear cell carcinoma of minor salivary glands. Histopathology. 1990;17(5):433–8.

    Article  CAS  Google Scholar 

  • Solar AA, Schmidt BL, Jordan RC. Hyalinizing clear cell carcinoma: case series and comprehensive review of the literature. Cancer. 2009;115(1):75–83.

    Article  Google Scholar 

  • Tanguay J, Weinreb I. What the EWSR1-ATF1 fusion has taught us about hyalinizing clear cell carcinoma. Head Neck Pathol. 2013;7:28–34.

    Article  Google Scholar 

  • Wang B, Brandwein M, Gordon R, Robinson R, Urken M, Zarbo RJ. Primary salivary clear cell tumors—a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. Arch Pathol Lab Med. 2002;126(6):676–85.

    PubMed  Google Scholar 

  • Weinreb I. Hyalinizing clear cell carcinoma of salivary gland: a review and update. Head Neck Pathol. 2013;7(Suppl 1):S20–9.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

García, J.J. (2019). Clear Cell Carcinoma. In: Atlas of Salivary Gland Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-09021-4_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-09021-4_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-09020-7

  • Online ISBN: 978-3-319-09021-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics