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Aortitis

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Pharmacotherapy in Aortic Disease

Part of the book series: Current Cardiovascular Therapy ((CCT,volume 7))

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Abstract

“Aortitis” is the generic term for inflammation of the aorta. This definition encompasses multiple etiologies, classified as infectious and non-infectious. This chapter appraises the pathophysiology, clinical picture, diagnosis and therapy (in particular traditional and novel pharmacotherapy) of infectious and non-infectious aortitis.

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References

  1. Gornik HL, Creager MA. Aortitis. Circulation. 2008;117:3039–51.

    PubMed Central  PubMed  Google Scholar 

  2. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Arthritis Rheum. 2013;65:1–11.

    CAS  PubMed  Google Scholar 

  3. Slobodin G, Naschitz JE, Zuckerman E, Zisman D, Rozenbaum M, Boulman N, et al. Aortic involvement in rheumatic diseases. Clin Exp Rheumatol. 2006;24(2 Suppl 41):S41–7.

    CAS  PubMed  Google Scholar 

  4. Salvarani C, Crowson CS, O’Fallon WM, Hunder GG, Gabriel SE. Reappraisal of the epidemiology of giant cell arteritis in Olmsted County, Minnesota, over a fifty-year period. Arthritis Rheum. 2004;51:264–8.

    PubMed  Google Scholar 

  5. Hunder GG. Epidemiology of giant-cell arteritis. Cleve Clin J Med. 2002;69 Suppl 2:SII79–82.

    PubMed  Google Scholar 

  6. Cid MC, Merkel PA. Giant cell arteritis. In: Creager M, Beckman J, Loscalzo J, editors. Vascular medicine: a companion to Braunwald’s heart disease. 2nd ed. Saunders (USA); 2012. p. 525–32.

    Google Scholar 

  7. Weyand CM, Tetzlaff N, Björnsson J, Brack A, Younge B, Goronzy JJ. Disease patterns and tissue cytokine profiles in giant cell arteritis. Arthritis Rheum. 1997;40:19–26.

    CAS  PubMed  Google Scholar 

  8. Maksimowicz-McKinnon K, Hoffman GS. Takayasu’s arteritis. In: Creager M, Beckman J, Loscalzo J, editors. Vascular medicine: a companion to Braunwald’s heart disease. 2nd ed. Saunders (USA); 2012. p. 520–4.

    Google Scholar 

  9. Langford CA: Takayasu’s arteritis. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. Rheumatology. 3rd ed. Mosby (USA); 2003.

    Google Scholar 

  10. Gravanis MB. Giant cell arteritis and Takayasu aortitis: morphologic, pathogenetic and etiologic factors. Int J Cardiol. 2000;75 Suppl 1:S21–33.

    PubMed  Google Scholar 

  11. Bennett DL, Ohashi K, El-Khoury GY. Spondyloarthropathies: ankylosing spondylitis and psoriatic arthritis. Radiol Clin North Am. 2004;42:121–34.

    PubMed  Google Scholar 

  12. Palazzi C, Salvarani C, D’Angelo S, Olivieri I. Aortitis and periaortitis in ankylosing spondylitis. Joint Bone Spine. 2011;78:451–5.

    PubMed  Google Scholar 

  13. St Clair EW, McCallum RM. Cogan’s syndrome. Curr Opin Rheumatol. 1999;11:47–52.

    CAS  PubMed  Google Scholar 

  14. Greco A, Gallo A, Fusconi M, Magliulo G, Turchetta R, Marinelli C, et al. Cogan’s syndrome: an autoimmune inner ear disease. Autoimmun Rev. 2013;12:396–400.

    CAS  PubMed  Google Scholar 

  15. Tseng JF, Cambria RP, Aretz HT, Brewster DC. Thoracoabdominal aortic aneurysm in Cogan’s syndrome. J Vasc Surg. 1999;30:565–8.

    CAS  PubMed  Google Scholar 

  16. Gürgün C, Ercan E, Ceyhan C, Yavuzgil O, Zoghi M, Aksu K, et al. Cardiovascular involvement in Behçet’s disease. Jpn Heart J. 2002;43:389–98.

    PubMed  Google Scholar 

  17. Hamza M. Large artery involvement in Behçet’s disease. J Rheumatol. 1987;14:554–9.

    CAS  PubMed  Google Scholar 

  18. Chae EJ, Do KH, Seo JB, Park SH, Kang JW, Jang YM, et al. Radiologic and clinical findings of Behçet disease: comprehensive review of multisystemic involvement. Radiographics. 2008;28:e31.

    PubMed  Google Scholar 

  19. Chirinos JA, Tamariz LJ, Lopes G, Del Carpio F, Zhang X, Milikowski C, et al. Large vessel involvement in ANCA-associated vasculitides: report of a case and review of the literature. Clin Rheumatol. 2004;23:152–9.

    PubMed  Google Scholar 

  20. Tavora F, Burke A. Review of isolated ascending aortitis: differential diagnosis, including syphilitic, Takayasu’s and giant cell aortitis. Pathology. 2006;38:302–8.

    PubMed  Google Scholar 

  21. Restrepo CS, Ocazionez D, Suri R, Vargas D. Aortitis: imaging spectrum of the infectious and inflammatory conditions of the aorta. Radiographics. 2011;31:435–51.

    PubMed  Google Scholar 

  22. Stone JR. Aortitis, periaortitis, and retroperitoneal fibrosis, as manifestations of IgG4-related systemic disease. Curr Opin Rheumatol. 2011;23:88–94.

    CAS  PubMed  Google Scholar 

  23. Foote EA, Postier RG, Greenfield RA, Bronze MS. Infectious aortitis. Curr Treat Options Cardiovasc Med. 2005;7:89–97.

    PubMed  Google Scholar 

  24. Valentine RJ, Plummer MM. Vascular infections. In: Creager M, Beckman J, Loscalzo J, editors. Vascular medicine: a companion to Braunwald’s heart disease. 2nd ed. Saunders (USA); 2012. 709–26.

    Google Scholar 

  25. Gomes MN, Choyke PL, Wallace RB. Infected aortic aneurysms: a changing entity. Ann Surg. 1992;215:435–42.

    CAS  PubMed Central  PubMed  Google Scholar 

  26. Schmidt WA, Gromnica-Ihle E. What is the best approach to diagnosing large-vessel vasculitis? Best Pract Res Clin Rheumatol. 2005;19:223–42.

    PubMed  Google Scholar 

  27. Hunder GG, Bloch DA, Michel BA, Stevens MB, Arend WP, Calabrese LH, et al. The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum. 1990;33:1122–8.

    CAS  PubMed  Google Scholar 

  28. Bossert M, Prati C, Balblanc JC, Lohse A, Wendling D. Aortic involvement in giant cell arteritis: current data. Joint Bone Spine. 2011;78:246–51.

    PubMed  Google Scholar 

  29. Nuenninghoff DM, Hunder GG, Christianson TJ, McClelland RL, Matteson EL. Incidence and heumattors of large-artery complication (aortic aneurysm, aortic dissection, and/or large-artery stenosis) in patients with giant cell arteritis: a population-based study over 50 years. Arthritis Rheum. 2003;48:3522–31.

    PubMed  Google Scholar 

  30. Scheel AK, Meller J, Vosshenrich R, Kohlhoff E, Siefker U, Müller GA, et al. Diagnosis and follow up of aortitis in the elderly. Ann Rheum Dis. 2004;63:1507–10.

    CAS  PubMed Central  PubMed  Google Scholar 

  31. Johnston SL, Lock RJ, Gompels MM. Takayasu arteritis: a review. J Clin Pathol. 2002;55:481–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  32. Hiratzka LF, Bakris GL, Beckman JA, Bersin RM, Carr VF, Casey Jr DE, et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Circulation. 2010;121:e266–369.

    PubMed  Google Scholar 

  33. Sueyoshi E, Sakamoto I, Hayashi K. Aortic aneurysms in patients with Takayasu’s arteritis: CT evaluation. AJR Am J Roentgenol. 2000;175:1727–33.

    CAS  PubMed  Google Scholar 

  34. Tavora F, Jeudy J, Gocke C, Burke A. Takayusu aortitis with acute dissection and hemopericardium. Cardiovasc Pathol. 2005;14:320–3.

    PubMed  Google Scholar 

  35. Arend WP, Michel BA, Bloch DA, Hunder GG, Calabrese LH, Edworthy SM, et al. The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum. 1990;33:1129–34.

    CAS  PubMed  Google Scholar 

  36. Roldan CA, Chavez J, Wiest PW, Qualls CR, Crawford MH. Aortic root disease and valve disease associated with ankylosing spondylitis. J Am Coll Cardiol. 1998;32:1397–404.

    CAS  PubMed  Google Scholar 

  37. Grasland A, Pouchot J, Hachulla E, Blétry O, Papo T, Vinceneux P. Study Group for Cogan’s Syndrome. Typical and atypical Cogan’s syndrome: 32 cases and review of the literature. Rheumatology (Oxford). 2004;43:1007–15.

    CAS  Google Scholar 

  38. Selim AG, Fulford LG, Mohiaddin RH, Sheppard MN. Active aortitis in relapsing polychondritis. J Clin Pathol. 2001;54:890–2.

    CAS  PubMed Central  PubMed  Google Scholar 

  39. Rojo-Leyva F, Ratliff NB, Cosgrove 3rd DM, Hoffman GS. Study of 52 patients with idiopathic aortitis from a cohort of 1,204 surgical cases. Arthritis Rheum. 2000;43:901–7.

    CAS  PubMed  Google Scholar 

  40. Revest M, Decaux O, Cazalets C, Verohye JP, Jégo P, Grosbois B. Thoracic infectious aortitis: microbiology, pathophysiology and treatment. Rev Med Interne. 2007;28:108–15.

    CAS  PubMed  Google Scholar 

  41. Cartery C, Astudillo L, Deelchand A, Moskovitch G, Sailler L, Bossavy JP, et al. Abdominal infectious aortitis caused by Streptococcus pneumonia: a case report and literature review. Ann Vasc Surg. 2011;25:266.e9–16.

    Google Scholar 

  42. Roberts WC, Ko JM, Vowels TJ. Natural history of syphilitic aortitis. Am J Cardiol. 2009;104:1578–87.

    PubMed  Google Scholar 

  43. Merkel PA. Overview of vasculitis. In: Creager M, Beckman J, Loscalzo J, editors. Vascular medicine: a companion to Braunwald’s heart disease. 2nd ed. Saunders (USA); 2012. p. 507–19.

    Google Scholar 

  44. Schmidt WA, Kraft HE, Borkowski A, Gromnica-Ihle EJ. Colour duplex ultrasonography in large-vessel giant cell arteritis. Scand J Rheumatol. 1999;28:374–6.

    CAS  PubMed  Google Scholar 

  45. Schmidt WA. Imaging in vasculitis. Best Pract Res Clin Rheumatol. 2013;27:107–18.

    PubMed  Google Scholar 

  46. Hautzel H, Sander O, Heinzel A, Schneider M, Müller HW. Assessment of large-vessel involvement in giant cell arteritis with 18 F-FDG PET: introducing an ROC-analysis-based cutoff ratio. J Nucl Med. 2008;49:1107–13.

    PubMed  Google Scholar 

  47. Schmidt WA, Blockmans D. Use of ultrasonography and positron emission tomography in the diagnosis and assessment of large-vessel vasculitis. Curr Opin Rheumatol. 2005;17:9–15.

    PubMed  Google Scholar 

  48. Ceriani L, Oberson M, Marone C, Gallino A, Giovanella L. F-18 FDG PET-CT Imaging in the care-management of a patient with pan-aortitis and coronary involvement. Clin Nucl Med. 2007;32:562–4.

    PubMed  Google Scholar 

  49. Choe YH, Han BK, Koh EM, Kim DK, Do YS, Lee WR. Takayasu’s arteritis: assessment of disease activity with contrast-enhanced MR imaging. AJR Am J Roentgenol. 2000;175:505–11.

    CAS  PubMed  Google Scholar 

  50. Schmidt WA, Nerenheim A, Seipelt E, Poehls C, Gromnica-Ihle E. Diagnosis of early Takayasu arteritis by colour Doppler ultrasonography. Rheumatology. 2002;41:496–502.

    CAS  PubMed  Google Scholar 

  51. Roldán-Valadéz E, Hernández-Martínez P, Osorio-Peralta S, Elizalde-Acosta I, Espinoza-Cruz V, Casián-Castellanos G. Imaging diagnosis of subclavian steal syndrome secondary to Takayasu arteritis affecting a left-side subclavian artery. Arch Med Res. 2003;34:433–8.

    PubMed  Google Scholar 

  52. Song JK, Jeong YH, Kang DH, Song JM, Song H, Choo SJ, et al. Echocardiographic and clinical characteristics of aortic regurgitation because of systemic vasculitis. J Am Soc Echocardiogr. 2003;16:850–7.

    PubMed  Google Scholar 

  53. Mukhtyar C, Guillevin L, Cid MC, Dasgupta B, de Groot K, Gross W, et al. EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis. 2009;68:318–23.

    CAS  PubMed  Google Scholar 

  54. Chowdhary VR, Crowson CS, Bhagra AS, Warrington KG, Vrtiska TJ. CT angiographic imaging characteristics of thoracic idiopathic aortitis. J Cardiovasc Comput Tomogr. 2013;7:297–302.

    PubMed  Google Scholar 

  55. Wang H, Smith RN, Spooner AE, Isselbacher EM, Cambria RP, MacGillivray TE, et al. Giant cell aortitis of the ascending aorta without signs or symptoms of systemic vasculitis is associated with elevated risk of distal aortic events. Arthritis Rheum. 2012;64:317–9.

    PubMed  Google Scholar 

  56. Iino M, Kuribayashi S, Imakita S, Takamiya M, Matsuo H, Ookita Y, et al. Sensitivity and specificity of CT in the diagnosis of inflammatory abdominal aortic aneurysms. J Comput Assist Tomogr. 2002;26:1006–12.

    PubMed  Google Scholar 

  57. Cronin CG, Lohan DG, Blake MA, Roche C, McCarthy P, Murphy JM. Retroperitoneal fibrosis: a review of clinical features and imaging findings. AJR Am J Roentgenol. 2008;191:423–31.

    PubMed  Google Scholar 

  58. Malouf JF, Chandrasekaran K, Orszulak TA. Mycotic aneurysms of the thoracic aorta: a diagnostic challenge. Am J Med. 2003;115:489–96.

    PubMed  Google Scholar 

  59. Wein M, Bartel T, Kabatnik M, Sadony V, Dirsch O, Erbel R. Rapid progression of bacterial aortitis to an ascending aortic mycotic aneurysm documented by transesophageal echocardiography. J Am Soc Echocardiogr. 2001;14:646–9.

    CAS  PubMed  Google Scholar 

  60. Wilson SE, Van Wagenen P, Passaro Jr E. Arterial infection. Curr Probl Surg. 1978;15:1–89.

    CAS  PubMed  Google Scholar 

  61. Macedo TA, Stanson AW, Oderich GS, Johnson CM, Panneton JM, Tie ML. Infected aortic aneurysms: imaging findings. Radiology. 2004;231:250–7.

    PubMed  Google Scholar 

  62. Litmanovich DE, Yıldırım A, Bankier AA. Insights into imaging of aortitis. Insights Imaging. 2012;3:545–60.

    PubMed Central  PubMed  Google Scholar 

  63. Huang JS, Ho AS, Ahmed A, Bhalla S, Menias CO. Borne identity: CT imaging of vascular infections. Emerg Radiol. 2011;18:335–43.

    PubMed  Google Scholar 

  64. Katabathina VS, Restrepo CS. Infectious and noninfectious aortitis: cross-sectional imaging findings. Semin Ultrasound CT MR. 2012;33:207–21.

    PubMed  Google Scholar 

  65. Long R, Guzman R, Greenberg H, Safneck J, Hershfield E. Tuberculous mycotic aneurysm of the aorta: review of published medical and surgical experience. Chest. 1999;115:522–31.

    CAS  PubMed  Google Scholar 

  66. Kimura F, Satoh H, Sakai F, Nishii N, Tohda J, Fujimura M, et al. Computed tomographic findings of syphilitic aortitis. Cardiovasc Intervent Radiol. 2004;27:179–81.

    PubMed  Google Scholar 

  67. Bodhey NK, Gupta AK, Neelakandhan KS, Unnikrishnan M. Early sternal erosion and luetic aneurysms of thoracic aorta: report of 6 cases and analysis of cause-effect relationship. Eur J Cardiothorac Surg. 2005;28:499–501.

    PubMed  Google Scholar 

  68. Tomey MI, Murthy VL, Beckman JA. Giant syphilitic aortic aneurysm: a case report and review of the literature. Vasc Med. 2011;16:360–4.

    PubMed  Google Scholar 

  69. Dasgupta B, Borg FA, Hassan N, Alexander L, Barraclough K, Bourke B, et al. BSR and BHPR guidelines for the management of giant cell arteritis. Rheumatology (Oxford). 2010;49:1594–7.

    Google Scholar 

  70. Proven A, Gabriel SE, Orces C, O’Fallon M, Hunder GG. Glucocorticoid therapy in giant cell arteritis: duration and adverse outcomes. Arthritis Rheum. 2003;49:703–8.

    CAS  PubMed  Google Scholar 

  71. De Silva M, Hazleman BL. Azathioprine in giant cell arteritis/polymyalgia rheumatica: a double-blind study. Ann Rheum Dis. 1986;45:136–8.

    PubMed Central  PubMed  Google Scholar 

  72. Hoffman GS, Cid MC, Hellmann DB, Guillevin L, Stone JH, Schousboe J, et al., for the International Network for the Study of Systemic Vasculitides (INSSYS). A multicenter, randomized, double-blind, placebo-controlled trial of adjuvant methotrexate treatment for giant cell arteritis. Arthritis Rheum. 2002;46:1309–18.

    Google Scholar 

  73. Jover JA, Hernandez-Garcia C, Morado IC, Vargas E, Banares A, Fernandez-Gutierrez B. Combined treatment of giant-cell arteritis with methotrexate and prednisone: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2001;134:106–14.

    CAS  PubMed  Google Scholar 

  74. Spiera RF, Mitnick HJ, Kupersmith M, Richmond M, Spiera H, Peterson MG, et al. A prospective, double-blind, randomized, placebo controlled trial of methotrexate in the treatment of giant cell arteritis (GCA). Clin Exp Rheumatol. 2001;19:495–501.

    CAS  PubMed  Google Scholar 

  75. Mahr AD, Jover JA, Spiera RF, Hèrnandez-Garcìa C, Fernàndez-Gutiérrez B, LaValley MP, et al. Adjunctive methotrexate for treatment of giant cell arteritis: an individual patient data meta-analysis. Arthritis Rheum. 2007;56:2789–97.

    CAS  PubMed  Google Scholar 

  76. Achkar AA, Lie JT, Hunder GG, O’Fallon WM, Gabriel SE. How does previous corticosteroid treatment affect the biopsy findings in giant cell (temporal) arteritis? Ann Intern Med. 1994;120:987–92.

    CAS  PubMed  Google Scholar 

  77. Weyand CM, Fulbright JW, Hunder GG, Evans JM, Goronzy JJ. Treatment of giant cell arteritis: interleukin-6 as a biologic marker of disease activity. Arthritis Rheum. 2000;43:1041–8.

    CAS  PubMed  Google Scholar 

  78. Lee MS, Smith SD, Galor A, Hoffman GS. Antiplatelet and anticoagulant therapy in patients with giant cell arteritis. Arthritis Rheum. 2006;54:3306–9.

    PubMed  Google Scholar 

  79. Salvarani C, Della Bella C, Cimino L, Macchioni P, Formisano D, Bajocchi G, et al. Risk factors for severe cranial ischaemic events in an Italian population-based cohort of patients with giant cell arteritis. Rheumatology (Oxford). 2009;48:250–3.

    CAS  Google Scholar 

  80. Weyand CM, Kaiser M, Yang H, Younge B, Goronzy JJ. Therapeutic effects of acetylsalicylic acid in giant cell arteritis. Arthritis Rheum. 2002;46:457–66.

    CAS  PubMed  Google Scholar 

  81. Keser G, Direskeneli H, Aksu K. Management of Takayasu arteritis: a systematic review. Rheumatology. 2014;53:793–801.

    CAS  PubMed  Google Scholar 

  82. Maximowicz-McKinnon K, Clark TM, Hoffmann GS. Limitations of therapy and a guarded prognosis in an American cohort of Takayasu arteritis patients. Arthritis Rheum. 2007;56:1000–9.

    Google Scholar 

  83. Wen D, Du X, Ma CS. Takayasu arteritis: diagnosis. Treatment and prognosis. Int Rev Immunol. 2012;31:462–73.

    CAS  PubMed  Google Scholar 

  84. Hoffman GS, Leavitt RY, Kerr GS, Rottem M, Sneller MC, Fauci AS. Treatment of glucocorticoid-resistant or relapsing Takayasu arteritis with methotrexate. Arthritis Rheum. 1994;37:578–82.

    CAS  PubMed  Google Scholar 

  85. Saruhan-Direskeneli G, Hughes T, Aksu K, Keser G, Coit P, Aydin SZ, et al. Identification of multiple genetic susceptibility loci in Takayasu arteritis. Am J Hum Genet. 2013;93:298–305.

    CAS  PubMed Central  PubMed  Google Scholar 

  86. Hoffman GS, Merkel PA, Brasington RD, Lenschow DJ, Liang P. Anti–tumor necrosis factor therapy in patients with difficult to treat Takayasu arteritis. Arthritis Rheum. 2004;50:2296–304.

    CAS  PubMed  Google Scholar 

  87. Mazlumzadeh M, Hunder GG, Easley KA, Calamia KT, Matteson EL, Griffing WL, et al. Treatment of giant cell arteritis using induction therapy with high-dose glucocorticoids: a double-blind, placebo-controlled, randomized prospective clinical trial. Arthritis Rheum. 2006;54:3310–8.

    CAS  PubMed  Google Scholar 

  88. Ohara N, Miyata T, Sato O, Oshiro H, Shigematsu H. Aortic aneurysm in patients with autoimmune diseases treated with corticosteroids. Int Angiol. 2000;19:270–5.

    CAS  PubMed  Google Scholar 

  89. Amezcua-Guerra LM, editor. Advances in the diagnosis and treatment of vasculitis. InTech (Croatia); 2011. ISBN 978-953-307-786-4. doi:10.5772/21534.

  90. Wagner AD, Wittkop U, Prahst A, Schmidt WA, Gromnica-Ihle E, Vorpahl K, et al. Dendritic cells colocalize with activated CD4-T cells in giant cell arteritis. Clin Exp Rheumatol. 2003;21:185–92.

    CAS  PubMed  Google Scholar 

  91. Field M, Cook A, Gallagher G. Immuno-localisation of tumour necrosis factor and its receptors in temporal arteritis. Rheumatol Int. 1997;17:113–8.

    CAS  PubMed  Google Scholar 

  92. Hoffman GS, Cid MC, Rendt-Zagar KE, Merkel PA, Weyand CM, Stone JH, et al. Infliximab for maintenance of glucocorticosteroid-induced remission of giant cell arteritis: a randomized trial. Ann Intern Med. 2007;146:621–30.

    PubMed  Google Scholar 

  93. Martínez-Taboada VM, Rodríguez-Valverde V, Carreño L, López-Longo J, Figueroa M, Belzunegui J, et al. A double-blind placebo controlled trial of etanercept in patients with giant cell arteritis and corticosteroid side effects. Ann Rheum Dis. 2008;67:625–30.

    PubMed  Google Scholar 

  94. Molloy ES, Langford CA, Clark TM, Gota CE, Hoffman GS. Anti-tumour necrosis factor therapy in patients with refractory Takayasu arteritis: long-term follow-up. Ann Rheum Dis. 2008;67:1567–9.

    CAS  PubMed  Google Scholar 

  95. Naka T, Nishimoto N, Kishimoto T. The paradigm of IL-6: from basic science to medicine. Arthritis Res. 2002;4 Suppl 3:S233–42.

    PubMed Central  PubMed  Google Scholar 

  96. Unizony S, Stone JH, Stone JR. New treatment strategies in large-vessel vasculitis. Curr Opin Rheumatol. 2013;25:3–9.

    CAS  PubMed  Google Scholar 

  97. Clifford A, Hoffman GS. Recent advances in the medical management of Takayasu arteritis: an update on use of biologic therapies. Curr Opin Rheumatol. 2014;26:7–15.

    CAS  PubMed  Google Scholar 

  98. Lund FE, Randall TD. Effector and regulatory B cells: modulators of CD4+ T-cell immunity. Nat Rev Immunol. 2010;10:236–47.

    CAS  PubMed Central  PubMed  Google Scholar 

  99. Bhatia A, Ell PJ, Edwards JC. Anti-CD20 monoclonal antibody (rituximab) as an adjunct in the treatment of giant cell arteritis. Ann Rheum Dis. 2005;64:1099–100.101.

    CAS  PubMed Central  PubMed  Google Scholar 

  100. Adizie T, Christidis D, Dharmapaliah C, Borg F, Dasgupta B. Efficacy and tolerability of leflunomide in difficult-to-treat polymyalgia rheumatica and giant cell arteritis: a case series. Int J Clin Pract. 2012;66:906–9.

    CAS  PubMed  Google Scholar 

  101. de Souza AW, da Silva MD, Machado LS, Oliveira AC, Pinheiro FA, Sato EI. Short-term effect of leflunomide in patients with Takayasu arteritis: an observational study. Scand J Rheumatol. 2012;41:227–30.

    PubMed  Google Scholar 

  102. Schäfer VS, Zwerina J. Biologic treatment of large-vessel vasculitides. Curr Opin Rheumatol. 2012;24:31–7.

    PubMed  Google Scholar 

  103. Callhoff J, Sieper J, Weiß A, Zink A, Listing J. Efficacy of TNFα blockers in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a meta-analysis. Ann Rheum Dis. 2014. doi:10.1136/annrheumdis-2014-205322.

    Google Scholar 

  104. Langford CA. Drug insight: anti-tumor necrosis factor therapies for the vasculitic diseases. Nat Clin Pract Rheumatol. 2008;4:364–70.

    CAS  PubMed  Google Scholar 

  105. Lopes RJ, Almeida J, Dias PJ, Pinho P, Maciel MJ. Infectious thoracic aortitis: a literature review. Clin Cardiol. 2009;32:488–90.

    CAS  PubMed  Google Scholar 

  106. Soravia-Dunand VA, Loo VG, Salit IE. Aortitis due to Salmonella: report of 10 cases and comprehensive review of the literature. Clin Infect Dis. 1999;29:862–8.

    CAS  PubMed  Google Scholar 

  107. Wilks D, Farrington M, Rubenstein D. Streptococci and their relatives. In: The infectious diseases manual. 2nd ed. Oxford: Blackwell Science Ltd; 2008.

    Google Scholar 

  108. Wilks D, Farrington M, Rubenstein D. Staphylococci. In: The infectious diseases manual. 2nd ed. Oxford: Blackwell Science Ltd; 2008.

    Google Scholar 

  109. Cohen SE, Klausner JD, Engelman J, Philip S. Syphilis in the modern era: an update for physicians. Infect Dis Clin North Am. 2013;27:705–22.

    PubMed  Google Scholar 

  110. Wilks D, Farrington M, Rubenstein D. Mycobacteria and mycobacterial infections. In: The infectious diseases manual. 2nd ed. Oxford: Blackwell Science Ltd; 2008.

    Google Scholar 

  111. Gornik HL, Creager MA. Diseases of the aorta. In: Topol EJ, editor. Textbook of cardiovascular medicine. 3rd ed. Philadelphia: Lippincott, Williams & Wilkins; 2007.

    Google Scholar 

  112. Vanoli M, Daina E, Salvarani C, Sabbadini MG, Rossi C, Bacchiani G, et al. Takayasu’s arteritis: a study of 104 Italian patients. Arthritis Rheum. 2005;53:100–7.

    CAS  PubMed  Google Scholar 

  113. Lee BB, Laredo J, Neville R, et al. Endovascular management of Takayasu arteritis: is it a durable option? Vascular. 2009;17:138–46.

    PubMed  Google Scholar 

  114. Qureshi MA, Martin Z, Greenberg RK. Endovascular management of patients with Takayasu arteritis: stents versus stent Grafts. Semin Vasc Surg. 2011;24:44–52.

    PubMed  Google Scholar 

  115. Min PK, Park S, Jung JH, et al. Endovascular therapy combined with immunosuppressive treatment for occlusive arterial disease in patients with Takayasu’s arteritis. J Endovasc Ther. 2005;12:28–34.

    PubMed  Google Scholar 

  116. Isobe M. Takayasu arteritis revisited: current diagnosis and treatment. Int J Cardiol. 2013;168:3–10.

    PubMed  Google Scholar 

  117. Tyagi S, Verma PK, Gambhir DS, et al. Early and long-term results of subclavian angioplasty in aortoarteritis (Takayasu disease): comparison with atherosclerosis. Cardiovasc Intervent Radiol. 1998;21:219–24.

    CAS  PubMed  Google Scholar 

  118. Miyata T, Sato O, Deguchi J, et al. Anastomotic aneurysms after surgical treatment of Takayasu’s arteritis: a 40-year experience. J Vasc Surg. 1998;27:438–45.

    CAS  PubMed  Google Scholar 

  119. Both M, Aries PM, Muller-Hulsbeck S, Jahnke T, Schafer PJ, Gross WL, et al. Balloon angioplasty of arteries of the upper extremities in patients with extracranial giant-cell arteritis. Ann Rheum Dis. 2006;65:1124–30.

    CAS  PubMed Central  PubMed  Google Scholar 

  120. Baril DT, Carroccio A, Palchik E, Ellozy SH, Jacobs TS, Teodorescu V, et al. Endovascular treatment of complicated aortic aneurysms in patients with underlying arteriopathies. Ann Vasc Surg. 2006;20:464–71.

    PubMed  Google Scholar 

  121. Puchner S, Bucek RA, Rand T, Schoder M, Hölzenbein T, Kretschmer G, Reiter M, et al. Endovascular therapy of inflammatory aortic aneurysms: a meta-analysis. J Endovasc Ther. 2005;12:560–7.

    PubMed  Google Scholar 

  122. Brown KE, Heyer K, Rodriguez H, et al. Arterial reconstruction with cryopreserved human allografts in the setting of infection: a single-center experience with midterm follow-up. J Vasc Surg. 2009;49:660.

    PubMed  Google Scholar 

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Correspondence to Alessandro Della Corte MD, PhD .

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Corte, A.D., Buonocore, M., Bancone, C. (2015). Aortitis. In: Evangelista, A., Nienaber, C. (eds) Pharmacotherapy in Aortic Disease. Current Cardiovascular Therapy, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-09555-4_2

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