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Major Neurocognitive Disorders (Dementias)

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Handbook of Consultation-Liaison Psychiatry

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Abstract

Consultation-Liaison (CL) Psychiatrists are frequently consulted on patients with Major Neurocognitive Disorders (MNCDs; DSM-5), formerly known as dementia. The questions usually posed include determination of decisional making capacity, management of delirium superimposed on MNCD, diagnosing the etiology of and assisting with the management of behavioral and psychiatric symptoms (e.g., mood, psychotic or behavioral symptoms) due to MNCD.

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References

  • Alzheimer’s Disease International. (2008). The prevalence of dementia worldwide. Alzheimer’s Disease International.

    Google Scholar 

  • Alzheimer’s Disease International. (2013). Dementia statistics: Numbers of people with dementia.

    Google Scholar 

  • APA. (2013). Diagnostic and statistical manual of mental disorders (DSM-5) (5th ed.). Washington, DC: American Psychiatric Association.

    Google Scholar 

  • Appelbaum, P. S. (2007). Clinical practice. Assessment of patients’ competence to consent to treatment. New England Journal of Medicine, 357(18), 1834–1840.

    Article  CAS  PubMed  Google Scholar 

  • Asayama, K., Yamadera, H., Ito, T., Suzuki, H., Kudo, Y., & Endo, S. (2003). Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. Journal of Nippon Medical School, 70(4), 334–341.

    Article  PubMed  Google Scholar 

  • Babikian, V., & Ropper, A. H. (1987). Binswanger’s disease: A review. Stroke, 18(1), 2–12.

    Article  CAS  PubMed  Google Scholar 

  • Bains, J., Birks, J. S., & Dening, T. R. (2002). The efficacy of antidepressants in the treatment of depression in dementia. Cochrane Database of Systematic Reviews, 4, CD003944.

    PubMed  Google Scholar 

  • Ballard, C., Brown, R., Fossey, J., Douglas, S., Bradley, P., Hancock, J., et al. (2009). Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial). The American Journal of Geriatric Psychiatry, 17(9), 726–733.

    Article  PubMed  Google Scholar 

  • Ballard, C., & Corbett, A. (2013). Agitation and aggression in people with Alzheimer’s disease. Current Opinion in Psychiatry, 26(3), 252–259.

    Article  PubMed  Google Scholar 

  • Ballard, C., Corbett, A., Chitramohan, R., & Aarsland, D. (2009). Management of agitation and aggression associated with Alzheimer’s disease: Controversies and possible solutions. Current Opinion in Psychiatry, 22(6), 532–540.

    Article  PubMed  Google Scholar 

  • Ballard, C., Hanney, M. L., Theodoulou, M., Douglas, S., McShane, R., Kossakowski, K., et al. (2009). The dementia antipsychotic withdrawal trial (DART-AD): Long-term follow-up of a randomised placebo-controlled trial. Lancet Neurology, 8(2), 151–157.

    Article  CAS  Google Scholar 

  • Ballard, C., & Waite, J. (2006). The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer’s disease. Cochrane Database of Systematic Reviews, 1, CD003476.

    PubMed  Google Scholar 

  • Banerjee, S., Hellier, J., Dewey, M., Romeo, R., Ballard, C., Baldwin, R., et al. (2011). Sertraline or mirtazapine for depression in dementia (HTA-SADD): A randomised, multicentre, double-blind, placebo-controlled trial. Lancet, 378(9789), 403–411.

    Article  CAS  PubMed  Google Scholar 

  • Benoit, A. G., Campbell, B. I., Tanner, J. R., Staley, J. D., Wallbridge, H. R., Biehl, D. R., et al. (2005). Risk factors and prevalence of perioperative cognitive dysfunction in abdominal aneurysm patients. Journal of Vascular Surgery, 42(5), 884–890.

    Article  PubMed  Google Scholar 

  • Benson, D. F., Kuhl, D. E., Hawkins, R. A., Phelps, M. E., Cummings, J. L., & Tsai, S. Y. (1983). The fluorodeoxyglucose 18F scan in Alzheimer’s disease and multi-infarct dementia. Archives of Neurology, 40(12), 711–714.

    Article  CAS  PubMed  Google Scholar 

  • Bickel, H., Gradinger, R., Kochs, E., & Forstl, H. (2008). High risk of cognitive and functional decline after postoperative delirium. A three-year prospective study. Dementia and Geriatric Cognitive Disorders, 26(1), 26–31.

    Article  PubMed  Google Scholar 

  • Brodaty, H., & Arasaratnam, C. (2012). Meta-analysis of nonpharmacological interventions for neuropsychiatric symptoms of dementia. The American Journal of Psychiatry, 169(9), 946–953.

    Article  PubMed  Google Scholar 

  • Brookmeyer, R., Corrada, M. M., Curriero, F. C., & Kawas, C. (2002). Survival following a diagnosis of Alzheimer disease. Archives of Neurology, 59(11), 1764–1767.

    Article  PubMed  Google Scholar 

  • Cole, M. G., Ciampi, A., Belzile, E., & Zhong, L. (2009). Persistent delirium in older hospital patients: A systematic review of frequency and prognosis. Age and Ageing, 38(1), 19–26.

    Article  PubMed  Google Scholar 

  • Cooney, C., Murphy, S., Tessema, H., & Freyne, A. (2013). Use of low-dose gabapentin for aggressive behavior in vascular and mixed vascular/Alzheimer dementia. The Journal of Neuropsychiatry and Clinical Neurosciences, 25(2), 120–125.

    Article  CAS  PubMed  Google Scholar 

  • Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., et al. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science, 261(5123), 921–923.

    Article  CAS  PubMed  Google Scholar 

  • Cummings, J. L., Schneider, L., Tariot, P. N., Kershaw, P. R., & Yuan, W. (2004). Reduction of behavioral disturbances and caregiver distress by galantamine in patients with Alzheimer’s disease. The American Journal of Psychiatry, 161(3), 532–538.

    Article  PubMed  Google Scholar 

  • Declercq, T., Petrovic, M., Azermai, M., Vander Stichele, R., De Sutter, A. I., van Driel, M. L., et al. (2013). Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia. Cochrane Database of Systematic Reviews, 3, CD007726.

    PubMed  Google Scholar 

  • Eggenberger, E. (2007). Prion disease. Neurologic Clinics, 25(3), 833–842. viii.

    Article  PubMed  Google Scholar 

  • Emre, M., Aarsland, D., Albanese, A., Byrne, E. J., Deuschl, G., De Deyn, P. P., et al. (2004). Rivastigmine for dementia associated with Parkinson’s disease. New England Journal of Medicine, 351(24), 2509–2518.

    Article  CAS  PubMed  Google Scholar 

  • Enache, D., Winblad, B., & Aarsland, D. (2011). Depression in dementia: Epidemiology, mechanisms, and treatment. Current Opinion in Psychiatry, 24(6), 461–472.

    PubMed  Google Scholar 

  • Erkinjuntti, T. (2007). Vascular cognitive deterioration and stroke. Cerebrovascular Diseases, 24(Suppl 1), 189–194.

    Article  PubMed  Google Scholar 

  • Ferman, T. J., & Boeve, B. F. (2007). Dementia with Lewy bodies. Neurologic Clinics, 25(3), 741–760. vii.

    Article  PubMed Central  PubMed  Google Scholar 

  • Ferri, C. P., Prince, M., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., et al. (2005). Global prevalence of dementia: A Delphi consensus study. Lancet, 366(9503), 2112–2117.

    Article  PubMed Central  PubMed  Google Scholar 

  • Fong, T. G., Jones, R. N., Shi, P., Marcantonio, E. R., Yap, L., Rudolph, J. L., et al. (2009). Delirium accelerates cognitive decline in Alzheimer disease. Neurology, 72(18), 1570–1575.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Fox, C., Crugel, M., Maidment, I., Auestad, B. H., Coulton, S., Treloar, A., et al. (2012). Efficacy of memantine for agitation in Alzheimer’s dementia: A randomised double-blind placebo controlled trial. PLoS One, 7(5), e35185.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Franco, J. G., Valencia, C., Bernal, C., Ocampo, M. V., Trzepacz, P. T., Pablo, J., et al. (2010). Relationship between cognitive status at admission and incident delirium in older medical inpatients. The Journal of Neuropsychiatry and Clinical Neurosciences, 22(3), 329–337.

    Article  PubMed  Google Scholar 

  • Gauthier, S., Loft, H., & Cummings, J. (2008). Improvement in behavioural symptoms in patients with moderate to severe Alzheimer’s disease by memantine: A pooled data analysis. International Journal of Geriatric Psychiatry, 23(5), 537–545.

    Article  CAS  PubMed  Google Scholar 

  • Gauthier, S., Wirth, Y., & Mobius, H. J. (2005). Effects of memantine on behavioural symptoms in Alzheimer’s disease patients: An analysis of the neuropsychiatric inventory (NPI) data of two randomised, controlled studies. International Journal of Geriatric Psychiatry, 20(5), 459–464.

    Article  CAS  PubMed  Google Scholar 

  • Gehrman, P. R., Connor, D. J., Martin, J. L., Shochat, T., Corey-Bloom, J., & Ancoli-Israel, S. (2009). Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. The American Journal of Geriatric Psychiatry, 17(2), 166–169.

    Article  PubMed Central  PubMed  Google Scholar 

  • Geschwind, M. D., Haman, A., & Miller, B. L. (2007). Rapidly progressive dementia. Neurologic Clinics, 25(3), 783–807. vii.

    Article  PubMed Central  PubMed  Google Scholar 

  • Girard, T. D., Jackson, J. C., Pandharipande, P. P., Pun, B. T., Thompson, J. L., Shintani, A. K., et al. (2010). Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Critical Care Medicine, 38(7), 1513–1520.

    Article  PubMed Central  PubMed  Google Scholar 

  • Goate, A., Chartier-Harlin, M. C., Mullan, M., Brown, J., Crawford, F., Fidani, L., et al. (1991). Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature, 349(6311), 704–706.

    Article  CAS  PubMed  Google Scholar 

  • Gouras, G. (2009). Dementia. In L. Squire (Ed.), Encyclopedia of neuroscience (pp. 403–408). La Jolla, CA: Academic Press.

    Chapter  Google Scholar 

  • Griffiths, R. D., & Jones, C. (2007). Delirium, cognitive dysfunction and posttraumatic stress disorder. Current Opinion in Anaesthesiology, 20(2), 124–129.

    Article  PubMed  Google Scholar 

  • Hausner, L., Damian, M., Sartorius, A., & Frolich, L. (2011). Efficacy and cognitive side effects of electroconvulsive therapy (ECT) in depressed elderly inpatients with coexisting mild cognitive impairment or dementia. The Journal of Clinical Psychiatry, 72(1), 91–97.

    Article  PubMed  Google Scholar 

  • Hebert, R., & Brayne, C. (1995). Epidemiology of vascular dementia. Neuroepidemiology, 14(5), 240–257.

    Article  CAS  PubMed  Google Scholar 

  • Hodges, J. R., Davies, R., Xuereb, J., Kril, J., & Halliday, G. (2003). Survival in frontotemporal dementia. Neurology, 61(3), 349–354.

    Article  CAS  PubMed  Google Scholar 

  • Holmes, C., Wilkinson, D., Dean, C., Vethanayagam, S., Olivieri, S., Langley, A., et al. (2004). The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease. Neurology, 63(2), 214–219.

    Article  CAS  PubMed  Google Scholar 

  • Howard, R. J., Juszczak, E., Ballard, C. G., Bentham, P., Brown, R. G., Bullock, R., et al. (2007). Donepezil for the treatment of agitation in Alzheimer’s disease. New England Journal of Medicine, 357(14), 1382–1392.

    Article  CAS  PubMed  Google Scholar 

  • Howard, R., McShane, R., Lindesay, J., Ritchie, C., Baldwin, A., Barber, R., et al. (2012). Donepezil and memantine for moderate-to-severe Alzheimer’s disease. New England Journal of Medicine, 366(10), 893–903.

    Article  CAS  PubMed  Google Scholar 

  • Husebo, B. S., Ballard, C., Sandvik, R., Nilsen, O. B., & Aarsland, D. (2011). Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: Cluster randomised clinical trial. British Medical Journal, 343, d4065.

    Article  PubMed Central  PubMed  Google Scholar 

  • Huybrechts, K. F., Gerhard, T., Crystal, S., Olfson, M., Avorn, J., Levin, R., et al. (2012). Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: Population based cohort study. British Medical Journal, 344, e977.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Inouye, S., Rushing, J. T., Foreman, M. D., Palmer, R. M., & Pompei, P. (1998). Does delirium contribute to poor hospital outcomes? A three-site epidemiologic study. Journal of General Internal Medicine, 13(4), 234–242.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Iranzo, A., Tolosa, E., Gelpi, E., Molinuevo, J. L., Valldeoriola, F., Serradell, M., et al. (2013). Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: An observational cohort study. Lancet Neurology, 12(5), 443–453.

    Article  Google Scholar 

  • Jackson, J. C., Gordon, S. M., Hart, R. P., Hopkins, R. O., & Ely, E. W. (2004). The association between delirium and cognitive decline: A review of the empirical literature. Neuropsychology Review, 14(2), 87–98.

    Article  PubMed  Google Scholar 

  • Jagust, W. J., Budinger, T. F., & Reed, B. R. (1987). The diagnosis of dementia with single photon emission computed tomography. Archives of Neurology, 44(3), 258–262.

    Article  CAS  PubMed  Google Scholar 

  • Jansen, S. L., Forbes, D. A., Duncan, V., Morgan, D. G., & Malouf, R. (2011). Melatonin for the treatment of dementia. Cochrane Database of Systematic Reviews, 1, CD003802.

    Google Scholar 

  • Kalisvaart, K., Vreeswijk, R., de Jonghe, J. F., van der Ploeg, T., van Gool, W. A., & Eikelenboom, P. (2006). Risk factors and prediction of postoperative delirium in elderly hip-surgery patients: Implementation and validation of a medical risk factor model. Journal of the American Geriatrics Society, 54(5), 817–822.

    Article  PubMed  Google Scholar 

  • Kat, M. G., Vreeswijk, R., de Jonghe, J. F., van der Ploeg, T., van Gool, W. A., Eikelenboom, P., et al. (2008). Long-term cognitive outcome of delirium in elderly hip surgery patients. A prospective matched controlled study over two and a half years. Dementia and Geriatric Cognitive Disorders, 26(1), 1–8.

    Article  PubMed  Google Scholar 

  • Kertesz, A., & Munoz, D. G. (2002). Frontotemporal dementia. The Medical Clinics of North America, 86(3), 501–518. vi.

    Article  PubMed  Google Scholar 

  • Kim, Y., Wilkins, K. M., & Tampi, R. R. (2008). Use of gabapentin in the treatment of behavioural and psychological symptoms of dementia: A review of the evidence. Drugs and Aging, 25(3), 187–196.

    Article  CAS  PubMed  Google Scholar 

  • Konovalov, S., Muralee, S., & Tampi, R. R. (2008). Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: A literature review. International Psychogeriatrics, 20(2), 293–308.

    Article  PubMed  Google Scholar 

  • Larson, E. B., Shadlen, M. F., Wang, L., McCormick, W. C., Bowen, J. D., Teri, L., et al. (2004). Survival after initial diagnosis of Alzheimer disease. Annals of Internal Medicine, 140(7), 501–509.

    Article  PubMed  Google Scholar 

  • Lebert, F., Stekke, W., Hasenbroekx, C., & Pasquier, F. (2004). Frontotemporal dementia: A randomised, controlled trial with trazodone. Dementia and Geriatric Cognitive Disorders, 17(4), 355–359.

    Article  CAS  PubMed  Google Scholar 

  • Levkoff, S. E., Evans, D. A., Liptzin, B., Cleary, P. D., Lipsitz, L. A., Wetle, T. T., et al. (1992). Delirium. The occurrence and persistence of symptoms among elderly hospitalized patients. Archives of Internal Medicine, 152(2), 334–340.

    Article  CAS  PubMed  Google Scholar 

  • Leys, D., Henon, H., Mackowiak-Cordoliani, M. A., & Pasquier, F. (2005). Poststroke dementia. Lancet Neurology, 4(11), 752–759.

    Article  Google Scholar 

  • Lippa, C. F., Swearer, J. M., Kane, K. J., Nochlin, D., Bird, T. D., Ghetti, B., et al. (2000). Familial Alzheimer’s disease: Site of mutation influences clinical phenotype. Annals of Neurology, 48(3), 376–379.

    Article  CAS  PubMed  Google Scholar 

  • Litaker, D., Locala, J., Franco, K., Bronson, D. L., & Tannous, Z. (2001). Preoperative risk factors for postoperative delirium. General Hospital Psychiatry, 23(2), 84–89.

    Article  CAS  PubMed  Google Scholar 

  • Lobo, A., Launer, L. J., Fratiglioni, L., Andersen, K., Di Carlo, A., Breteler, M. M., et al. (2000). Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology, 54(11 Suppl 5), S4–S9.

    CAS  PubMed  Google Scholar 

  • Lonergan, E., & Luxenberg, J. (2009). Valproate preparations for agitation in dementia. Cochrane Database of Systematic Reviews, 3, CD003945.

    PubMed  Google Scholar 

  • Lopez, O. L., Becker, J. T., Chang, Y. F., Sweet, R. A., Aizenstein, H., Snitz, B., et al. (2013). The long-term effects of conventional and atypical antipsychotics in patients with probable Alzheimer’s disease. The American Journal of Psychiatry, 170(9), 1051–1058.

    Article  PubMed Central  PubMed  Google Scholar 

  • Lowery, D. P., Wesnes, K., & Ballard, C. G. (2007). Subtle attentional deficits in the absence of dementia are associated with an increased risk of post-operative delirium. Dementia and Geriatric Cognitive Disorders, 23(6), 390–394.

    Article  PubMed  Google Scholar 

  • Macdonald, A. J. (1999). Can delirium be separated from dementia? Dementia and Geriatric Cognitive Disorders, 10(5), 386–388.

    Article  CAS  PubMed  Google Scholar 

  • MacLullich, A. M., Beaglehole, A., Hall, R. J., & Meagher, D. J. (2009). Delirium and long-term cognitive impairment. International Review of Psychiatry, 21(1), 30–42.

    Article  PubMed  Google Scholar 

  • Maher, A. R., Maglione, M., Bagley, S., Suttorp, M., Hu, J. H., Ewing, B., et al. (2011). Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: A systematic review and meta-analysis. The Journal of the American Medical Association, 306(12), 1359–1369.

    Article  CAS  Google Scholar 

  • Maldonado, J. R. (2008a). Delirium in the acute care setting: Characteristics, diagnosis and treatment. Critical Care Clinics, 24(4), 657–722. vii.

    Article  CAS  PubMed  Google Scholar 

  • Maldonado, J. R. (2008b). Pathoetiological model of delirium: A comprehensive understanding of the neurobiology of delirium and an evidence-based approach to prevention and treatment. Critical Care Clinics, 24(4), 789–856. ix.

    Article  CAS  PubMed  Google Scholar 

  • Maldonado, J. R. (2013). Neuropathogenesis of delirium: A review of current etiological theories and common pathways. American Journal of Geriatric Psychiatry, 21(12), 1190–1222.

    Article  PubMed  Google Scholar 

  • Manoochehri, M., & Huey, E. D. (2012). Diagnosis and management of behavioral issues in frontotemporal dementia. Current Neurology and Neuroscience Reports, 12(5), 528–536.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Mariani, C., Defendi, S., Mailland, E., & Pomati, S. (2006). Frontotemporal dementia. Neurological Science, 27(Suppl 1), S35–S36.

    Article  Google Scholar 

  • McCusker, J., Cole, M., Dendukuri, N., Han, L., & Belzile, E. (2003). The course of delirium in older medical inpatients: A prospective study. Journal of General Internal Medicine, 18(9), 696–704.

    Article  PubMed Central  PubMed  Google Scholar 

  • McDowell, I. (2001). Alzheimer’s disease: Insights from epidemiology. Aging (Milano), 13(3), 143–162.

    CAS  Google Scholar 

  • McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014). The neuropathology of sport. Acta Neuropathologica, 127(1), 29–51.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • McKeith, I., Del Ser, T., Spano, P., Emre, M., Wesnes, K., Anand, R., et al. (2000). Efficacy of rivastigmine in dementia with Lewy bodies: A randomised, double-blind, placebo-controlled international study. Lancet, 356(9247), 2031–2036.

    Article  CAS  PubMed  Google Scholar 

  • McNicoll, L., Pisani, M. A., Zhang, Y., Ely, E. W., Siegel, M. D., & Inouye, S. K. (2003). Delirium in the intensive care unit: Occurrence and clinical course in older patients. Journal of the American Geriatrics Society, 51(5), 591–598.

    Article  PubMed  Google Scholar 

  • McShane, R., Areosa Sastre, A., & Minakaran, N. (2006). Memantine for dementia. Cochrane Database of Systematic Reviews, 2, CD003154.

    PubMed  Google Scholar 

  • Mega, M. S., Cummings, J. L., Fiorello, T., & Gornbein, J. (1996). The spectrum of behavioral changes in Alzheimer’s disease. Neurology, 46(1), 130–135.

    Article  CAS  PubMed  Google Scholar 

  • Mielke, M. M., Savica, R., Wiste, H. J., Weigand, S. D., Vemuri, P., Knopman, D. S., et al. (2014). Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study. Neurology, 82(1), 70–76.

    Article  CAS  PubMed  Google Scholar 

  • Mohamed, S., Rosenheck, R., Lyketsos, C. G., Kaczynski, R., Sultzer, D. L., & Schneider, L. S. (2012). Effect of second-generation antipsychotics on caregiver burden in Alzheimer’s disease. The Journal of Clinical Psychiatry, 73(1), 121–128.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Murray, J. L., Abraham, J., Mohammed, K. L., Alvarado, M., & Atkinson, C. (2013). The state of US health, 1990–2010: Burden of diseases, injuries, and risk factors. The Journal of the American Medical Association, 310(6), 591–608.

    Article  CAS  Google Scholar 

  • Nelson, J. C., & Devanand, D. P. (2011). A systematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia. Journal of the American Geriatrics Society, 59(4), 577–585.

    Article  PubMed  Google Scholar 

  • Ngandu, T., von Strauss, E., Helkala, E. L., Winblad, B., Nissinen, A., Tuomilehto, J., et al. (2007). Education and dementia: What lies behind the association? Neurology, 69(14), 1442–1450.

    Article  CAS  PubMed  Google Scholar 

  • Oudman, E. (2012). Is electroconvulsive therapy (ECT) effective and safe for treatment of depression in dementia? A short review. The Journal of ECT, 28(1), 34–38.

    Article  PubMed  Google Scholar 

  • Plassman, B. L., Langa, K. M., Fisher, G. G., Heeringa, S. G., Weir, D. R., Ofstedal, M. B., et al. (2007). Prevalence of dementia in the United States: The aging, demographics, and memory study. Neuroepidemiology, 29(1–2), 125–132.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Pollock, B. G., Mulsant, B. H., Rosen, J., Mazumdar, S., Blakesley, R. E., Houck, P. R., et al. (2007). A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia. The American Journal of Geriatric Psychiatry, 15(11), 942–952.

    Article  PubMed  Google Scholar 

  • Porsteinsson, A. P., Drye, L. T., Pollock, B. G., Devanand, D. P., Frangakis, C., Ismail, Z., et al. (2014). Effect of citalopram on agitation in Alzheimer disease: The CitAD randomized clinical trial. The Journal of the American Medical Association, 311(7), 682–691.

    Article  CAS  Google Scholar 

  • Ratnavalli, E., Brayne, C., Dawson, K., & Hodges, J. R. (2002). The prevalence of frontotemporal dementia. Neurology, 58(11), 1615–1621.

    Article  CAS  PubMed  Google Scholar 

  • Reitz, C., & Mayeux, R. (2014). Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers. Biochemical Pharmacology, 88(4), 640–651.

    Article  CAS  PubMed  Google Scholar 

  • Rockwood, K., Cosway, S., Carver, D., Jarrett, P., Stadnyk, K., & Fisk, J. (1999). The risk of dementia and death after delirium. Age and Ageing, 28(6), 551–556.

    Article  CAS  PubMed  Google Scholar 

  • Rodda, J., Morgan, S., & Walker, Z. (2009). Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer’s disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine. International Psychogeriatrics, 21(5), 813–824.

    Article  PubMed  Google Scholar 

  • Rudolph, J. L., Jones, R. N., Grande, L. J., Milberg, W. P., King, E. G., Lipsitz, L. A., et al. (2006). Impaired executive function is associated with delirium after coronary artery bypass graft surgery. Journal of the American Geriatrics Society, 54(6), 937–941.

    Article  PubMed Central  PubMed  Google Scholar 

  • Schneider, L. S., Dagerman, K. S., & Insel, P. (2005). Risk of death with atypical antipsychotic drug treatment for dementia: Meta-analysis of randomized placebo-controlled trials. The Journal of the American Medical Association, 294(15), 1934–1943.

    Article  CAS  Google Scholar 

  • Schneider, L. S., Dagerman, K., & Insel, P. S. (2006). Efficacy and adverse effects of atypical antipsychotics for dementia: Meta-analysis of randomized, placebo-controlled trials. The American Journal of Geriatric Psychiatry, 14(3), 191–210.

    Article  PubMed  Google Scholar 

  • Schneider, L. S., Tariot, P. N., Dagerman, K. S., Davis, S. M., Hsiao, J. K., Ismail, M. S., et al. (2006). Effectiveness of atypical antipsychotic drugs in patients with Alzheimer’s disease. New England Journal of Medicine, 355(15), 1525–1538.

    Article  CAS  PubMed  Google Scholar 

  • Seitz, D. P., Adunuri, N., Gill, S. S., Gruneir, A., Herrmann, N., & Rochon, P. (2011). Antidepressants for agitation and psychosis in dementia. Cochrane Database of Systematic Reviews, 2, CD008191.

    PubMed  Google Scholar 

  • Seitz, D. P., Brisbin, S., Herrmann, N., Rapoport, M. J., Wilson, K., Gill, S. S., et al. (2012). Efficacy and feasibility of nonpharmacological interventions for neuropsychiatric symptoms of dementia in long term care: A systematic review. Journal of the American Medical Directors Association, 13(6), 503–506.e2.

    Article  PubMed  Google Scholar 

  • Silverman, D. H., Small, G. W., Chang, C. Y., Lu, C. S., Kung De Aburto, M. A., Chen, W., et al. (2001). Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome. The Journal of the American Medical Association, 286(17), 2120–2127.

    Article  CAS  Google Scholar 

  • Smith, P. J., Attix, D. K., Weldon, B. C., Greene, N. H., & Monk, T. G. (2009). Executive function and depression as independent risk factors for postoperative delirium. Anesthesiology, 110(4), 781–787.

    Article  PubMed Central  PubMed  Google Scholar 

  • Tognoni, P., Simonato, A., Robutti, N., Pisani, M., Cataldi, A., Monacelli, F., et al. (2011). Preoperative risk factors for postoperative delirium (POD) after urological surgery in the elderly. Archives of Gerontology and Geriatrics, 52(3), e166–e169.

    Article  CAS  PubMed  Google Scholar 

  • Trinh, N. H., Hoblyn, J., Mohanty, S., & Yaffe, K. (2003). Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: A meta-analysis. The Journal of the American Medical Association, 289(2), 210–216.

    Article  CAS  Google Scholar 

  • Wacker, P., Nunes, P. V., Cabrita, H., & Forlenza, O. V. (2006). Post-operative delirium is associated with poor cognitive outcome and dementia. Dementia and Geriatric Cognitive Disorders, 21(4), 221–227.

    Article  PubMed  Google Scholar 

  • Wahlund, L., & Bjorlin, G. A. (1999). Delirium in clinical practice: Experiences from a specialized delirium ward. Dementia and Geriatric Cognitive Disorders, 10(5), 389–392.

    Article  CAS  PubMed  Google Scholar 

  • Walker, Z., Jaros, E., Walker, R. W., Lee, L., Costa, D. C., Livingston, G., et al. (2007). Dementia with Lewy bodies: A comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy. Journal of Neurology, Neurosurgery, and Psychiatry, 78(11), 1176–1181.

    Article  PubMed Central  PubMed  Google Scholar 

  • Wang, P. S., Schneeweiss, S., Avorn, J., Fischer, M. A., Mogun, H., Solomon, D. H., et al. (2005). Risk of death in elderly users of conventional vs. atypical antipsychotic medications. New England Journal of Medicine, 353(22), 2335–2341.

    Article  CAS  PubMed  Google Scholar 

  • Weder, N. D., Aziz, R., Wilkins, K., & Tampi, R. R. (2007). Frontotemporal dementias: A review. Annals of General Psychiatry, 6, 15.

    Article  PubMed Central  PubMed  Google Scholar 

  • Wilcock, G. K., Ballard, C. G., Cooper, J. A., & Loft, H. (2008). Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer’s disease: A pooled analysis of 3 studies. The Journal of Clinical Psychiatry, 69(3), 341–348.

    Article  CAS  PubMed  Google Scholar 

  • Yung, B., Moeller, J. J., Bitar, M., & Chong, D. (2010). Teaching NeuroImages: Hemispheric-onset Creutzfeldt-Jakob disease with concordant MRI and EEG findings. Neurology, 75(16), e66.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, 401 Quarry Road, Office #2320, Stanford, CA, 94305, USA

    Yelizaveta Sher MD (Assistant Clinical Professor of Psychiatry)

  2. Internal Medicine, Surgery & Law, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Office #2317, Stanford, CA, 94305, USA

    José R. Maldonado MD, FAPM, FACFE (Associate Professor of Psychiatry)

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  1. Yelizaveta Sher MD
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  2. José R. Maldonado MD, FAPM, FACFE
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Correspondence to Yelizaveta Sher MD .

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Editors and Affiliations

  1. Department of Psychiatry, University of California, San Francisco, Fresno Community Regional Medical Center, Fresno, California, USA

    Hoyle Leigh

  2. University of Hawaii at Manoa Department of Psychiatry, Honolulu, Hawaii, USA

    Jon Streltzer

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Sher, Y., Maldonado, J.R. (2015). Major Neurocognitive Disorders (Dementias). In: Leigh, H., Streltzer, J. (eds) Handbook of Consultation-Liaison Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-319-11005-9_13

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  • DOI: https://doi.org/10.1007/978-3-319-11005-9_13

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