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Individualized Medicine Within the GANI_MED Project

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Individualized Medicine

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 7))

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Abstract

In 2009 the University Medicine Greifswald, Germany, has launched the “Greifswald Approach to Individualized Medicine” (GANI_MED) project to address major challenges of Individualized Medicine. The major goals of Individualized Medicine require excellent clinical stratification of patients as well as the availability of genomic data and biomarkers as prerequisites for the development of novel diagnostic tools and therapeutic strategies. In this chapter, we describe the implementation of the scientific and clinical infrastructure. Patient cohorts with an emphasis on metabolic and cardiovascular diseases are being established aiming at the inclusion of more than 5,000 patients. Standardized protocols for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for biobanking have been developed. A multi-omics based biomarker assessment is applied to identify new biomarkers or biomarker-signatures that complement disease-specific biomarkers at an individual or stratified level. A central data management structure has been implemented to integrate all relevant clinical data for research and translational purposes. Ethical research projects on informed consent procedures and the reporting of incidental findings were initiated as well as health economic evaluations.

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Acknowledgement

The contribution to data collection performed by study nurses, study physicians, ultrasound technicians, interviewers, and laboratory workers is gratefully acknowledged. We are also appreciative of the important support of IT- and computer scientists, medical documentarists, and administration staff. We also thank all study participants whose personal dedication and commitment make this project possible.

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Authors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsmedizin Greifswald und HELIOS Klinik Stralsund, Rostocker Chaussee 70, 18437, Stralsund, Germany

    Hans-Jörgen Grabe

  2. Facharzt für Innere Medizin Endokrinologie Diabetologie Andrologie, Krampferstr. 6, 99084, Erfurt, Germany

    Henri Wallaschofski

Authors
  1. Hans-Jörgen Grabe
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  2. Henri Wallaschofski
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Correspondence to Hans-Jörgen Grabe .

Editor information

Editors and Affiliations

  1. University Medicine Greifswald, Department for Ethics, Theory and History in Life Sciences, Greifswald, Germany

    Tobias Fischer

  2. University of Greifswald, GANI_MED – Greifswald Approach to Individualized Medicine, Greifswald, Germany

    Martin Langanke

  3. University of Greifswald, GANI_MED – Greifswald Approach to Individualized Medicine, Greifswald, Germany

    Paul Marschall

  4. University Medicine of Johannes Gutenberg-University Mainz, Institute for History, Theory and Ethic of Medicine, Mainz, Germany

    Susanne Michl

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Grabe, HJ., Wallaschofski, H. (2015). Individualized Medicine Within the GANI_MED Project. In: Fischer, T., Langanke, M., Marschall, P., Michl, S. (eds) Individualized Medicine. Advances in Predictive, Preventive and Personalised Medicine, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-11719-5_3

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  • DOI: https://doi.org/10.1007/978-3-319-11719-5_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-11718-8

  • Online ISBN: 978-3-319-11719-5

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