Abstract
The present exposition of the AD-related pathological process rests upon some basic assumptions:
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References
Barulli D, Stern Y (2013) Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve. Trends Cogn Sci 17:502–509
Bengtsson SL, Nagy Z, Skare S et al (2005) Extensive piano practicing has regionally specific effects on white matter development. Nat Neurosci 8:1148–1150
Bulic B, Pickhardt M, Mandelkow EM, Mandelkow E (2010) Tau protein and tau aggregation inhibitors. Neuropharmacology 59:276–289
Craik FIM, Bialystok E, Freedman M (2010) Delaying the onset of Alzheimer’s disease. Bilingualism as a form of cognitive reserve. Neurology 75:1726–1729
Draganski B, May A (2008) Training-induced structural changes in the adult human brain. Behav Brain Res 192:137–142
Erickson KI, Weinstein AM, Lopez OL (2012) Physical activity, brain plasticity, and Alzheimer’s disease. Arch Med Res 43:615–621
Fields RD (2011) Imaging learning: the search for a memory trace. Neuroscientist 17:185–196
Freedman M, Alladi S, Chertkow H et al (2014) Delaying onset of dementia: are two languages enough? Behav Neurol 2014, 808137
Gärtner H, Minnerop M, Pieperhoff P et al (2013) Brain morphometry shows effects of long-term musical practice in middle-aged keyboard players. Front Psychol 4:636
Gong CX, Grundke-Iqbal I, Iqbal K (2010) Targeting tau protein in Alzheimer’s disease. Drugs Aging 27:351–365
Iqbal K, Grundke-Iqbal I (2011) Opportunities and challenges in developing Alzheimer disease therapeutics. Acta Neuropathol 122:543–549
Lou K, Yao Y, Hoye AT, James MJ et al (2014) Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer’s disease and related tauopathies. J Med Chem 57:6116–6127
Maarouf CL, Daugs ID, Kokjohn TA et al (2010) The biochemical aftermath of anti-amyloid immunotherapy. Mol Neurodegener 5:39–54
Meng X, D’Arcy C (2012) Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and quantitative analyses. PLoS One 7:e38268
Molnar FJ, Man-Son-Hing M, Fergusson D (2009) Systematic review of measures of clinical significance employed in randomized controlled trials of drugs for dementia. J Am Geriatr Soc 57:536–546
Morrison JH, Hof PR (1997) Life and death of neurons in the aging brain. Science 278:412–419
Nelson PT, Head E, Schmitt FA et al (2011) Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiologicical human studies. Acta Neuropathol 121:571–587
Reid AT, Evans AC (2013) Structural networks in Alzheimer’s disease. Eur Neuropsychopharmacol 23:63–77
Sanders DW, Kaufmann SW, DeVos SL et al (2014) Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron 82:1271–1288
Savica R, Petersen RC (2011) Prevention of dementia. Psychiatr Clin North Am 34:127–145
Schlaug G, Norton A, Overy K et al (2003) Effects of music training on the child’s brain and cognitive development. Ann NY Acad Sci 1060:219–230
Serrano-Pozo A, Quian J, Monsell SE et al (2013) Examination of the clinicopathological continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center. J Neuropathol Exp Neurol 72:1182–1192
Stern Y (2002) What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc 8:448–460
Stern Y (2009) Cognitive reserve. Neuropsychologia 47:2015–2028
Ullén F (2009) Is activity regulation of late myelination a plastic mechanism in the human nervous system? Neuron Glia Biol 5:29–34
Wagner J, Ryazanov S, Leonov A et al (2013) Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease. Acta Neuropathol 125:795–813
Xu W, Yu JT, Tan MS, Tan L (2014) Cognitive reserve and Alzheimer’s disease. Mol Neurobiol. May 4 [Epub ahead of print]
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Braak, H., Del Tredici, K. (2015). Final Considerations. In: Neuroanatomy and Pathology of Sporadic Alzheimer's Disease. Advances in Anatomy, Embryology and Cell Biology, vol 215. Springer, Cham. https://doi.org/10.1007/978-3-319-12679-1_10
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