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Posterior Ciliary Artery Occlusion and Choroidal Ischemia

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Ocular Vascular Occlusive Disorders

Abstract

The posterior ciliary arteries (PCAs) supply the choroid and the optic nerve head. As discussed in Chap. 4, information on the vascular pattern of the choroid and of the PCAs was previously drawn entirely from postmortem cast studies, ever since the first description by Frederik Ruysch [1] in 1700. Extensive anatomical studies of the choroidal vascular bed have been conducted, mostly by studying casts prepared by the postmortem injection of a variety of materials [2–8] and also by studying casts by scanning electron microscopy [9–12]. These studies formed the basis of the classical anatomical textbook description of the choroidal vasculature. According to most of these descriptions: (1) PCAs have no segmental distribution, (2) they anastomose freely with one another as well as with the anterior ciliary arteries, (3) there are inter-arterial and arteriovenous anastomoses in the choroid, and (4) the choriocapillaris forms a freely communicating and an uninterrupted vascular bed in the entire choroid [8, 11]. From these postmortem anatomical descriptions, it was generally concluded that occlusion of PCA or one of its branches should not produce an ischemic lesion.

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References

  1. Wedel C, Ruysch F. Epistola anatomica, problematica ad Fredericum Ruyschium. De oculorum tunicis. Amstelaedami: Janssonio-Waesbergios; 1737.

    Google Scholar 

  2. Ashton N. Observations on the choroidal circulation. Br J Ophthalmol. 1952;36:465–81.

    PubMed Central  CAS  PubMed  Google Scholar 

  3. Ring HG, Fujino T. Observations on the anatomy and pathology of the choroidal vasculature. Arch Ophthalmol. 1967;78:431–44.

    CAS  PubMed  Google Scholar 

  4. Ruskell GL. Choroidal vascularization in the rabbit. Am J Ophthalmol. 1961;52:807–15.

    CAS  PubMed  Google Scholar 

  5. Vilstrup G. Studies on the choroid circulation. Thesis (doctoral). Copenhagen: Ejnar Munksgaard; 1952.

    Google Scholar 

  6. Weiter JJ, Ernest JT. Anatomy of the choroidal vasculature. Am J Ophthalmol. 1974;78:583–90.

    CAS  PubMed  Google Scholar 

  7. Wybar KC. A study of the choroidal circulation of the eye in man. J Anat. 1954;88:94–8.

    PubMed Central  CAS  PubMed  Google Scholar 

  8. Wybar KC. Vascular anatomy of the choroid in relation to selective localization of ocular disease. Br J Ophthalmol. 1954;38:513–7.

    PubMed Central  CAS  PubMed  Google Scholar 

  9. Matsuo N. Studies on choroidal circulation. Nihon Ganka Gakkai Zasshi. 1980;84:2147–206.

    CAS  PubMed  Google Scholar 

  10. Shimizu K. Segmental nature of angioarchitecture of the choroid. In: Shimizu K, Oosterhuis JA, editors. Acta XXIII Concilium Ophthalmologicum, Kyoto, 1978. Part 1. Amsterdam: Excerpta Medica; 1979. p. 215–9.

    Google Scholar 

  11. Shimizu K, Ujiie K. Structure of ocular vessels. New York: Igaku-Shoin; 1978. p. 54, 70–9, 108–24.

    Google Scholar 

  12. Uyama M, Ohkuma H, Itotagawa S, Koshibu A, Uraguchi K, Miki K. Pathology of choroidal circulatory disturbance. Part 1. Angioarchitecture of the choroid, observation on plastic cast preparation (author’s transl). Nihon Ganka Gakkai Zasshi. 1980;84:1893–909.

    CAS  PubMed  Google Scholar 

  13. Hayreh SS, Baines JA. Occlusion of the posterior ciliary artery. I. Effects on choroidal circulation. Br J Ophthalmol. 1972;56:719–35.

    PubMed Central  CAS  PubMed  Google Scholar 

  14. Hayreh SS, Baines JA. Occlusion of the posterior ciliary artery. II. Chorio-retinal lesions. Br J Ophthalmol. 1972;56:736–53.

    PubMed Central  CAS  PubMed  Google Scholar 

  15. Hayreh SS, Baines JA. Occlusion of the posterior ciliary artery. III. Effects on the optic nerve head. Br J Ophthalmol. 1972;56:754–64.

    PubMed Central  CAS  PubMed  Google Scholar 

  16. Hayreh SS, Chopdar A. Occlusion of the posterior ciliary artery. V. Protective influence of simultaneous vortex vein occlusion. Arch Ophthalmol. 1982;100:1481–91.

    CAS  PubMed  Google Scholar 

  17. Loeffler KU, Hayreh SS, Tso MOM. The effects of simultaneous occlusion of the posterior ciliary artery and vortex veins: a histopathologic study. Arch Ophthalmol. 1994;112:674–82.

    CAS  PubMed  Google Scholar 

  18. Hayreh SS. Submacular choroidal vascular pattern. Experimental fluorescein fundus angiographic studies. Albrecht von Graefes Arch Klin Exp Ophthalmol. 1974;192:181–96.

    CAS  PubMed  Google Scholar 

  19. Hayreh SS. The long posterior ciliary arteries. An experimental study. Albrecht von Graefes Arch Klin Exp Ophthalmol. 1974;192:197–213.

    CAS  PubMed  Google Scholar 

  20. Uyama M, Ohkuma H, Miki K, Koshibu A, Uraguchi K, Itotagawa S. Pathology of choroidal circulatory disturbance. Part 3. Experimental choroidal circulatory disturbance, histopathological study of retino-choroidal lesion (author’s transl). Nihon Ganka Gakkai Zasshi. 1980;84:1924–46.

    CAS  PubMed  Google Scholar 

  21. Koshibu A, Itotagawa S. Disruption and repair of blood-retinal barrier at the retinal pigment epithelium after experimentally produced choroidal circulatory disturbance (author’s transl). Nihon Ganka Gakkai Zasshi. 1980;84:721–35.

    CAS  PubMed  Google Scholar 

  22. Wagenmann A. Experimental Investigation of the influence of the circulation within the retina and choroid for the nourishment of the eye, especially the retina, and about the consequences of optic nerve transection. Albrecht von Graefes Arch Ophthalmol. 1890;36:1–120.

    Google Scholar 

  23. Krückmann E. Anatomy of the retinal pigment epithelium. Albrecht von Graefes Arch Ophthalmol. 1899;47:644–61.

    Google Scholar 

  24. Capauner. Zustandekommen der Netzhautpigmentirung. Bericht Ophthalmologische Gesellschaft. 1893;23:45–75.

    Google Scholar 

  25. Nicholls JV. The effect of section of the posterior ciliary arteries in the rabbit. Br J Ophthalmol. 1938;22:672–87.

    PubMed Central  CAS  PubMed  Google Scholar 

  26. Algvere P. Retinal detachment and pathology following experimental embolization of choroidal and retinal circulation. Albrecht von Graefes Arch Klin Exp Ophthalmol. 1976;201:123–34.

    CAS  PubMed  Google Scholar 

  27. Ota M, Harayama K, Uyama M. Angiographic study of experimental occlusion of posterior ciliary arteries (author’s transl). Nihon Ganka Gakkai Zasshi. 1976;80:531–9.

    CAS  PubMed  Google Scholar 

  28. Ueno S, Tsukahara I. Ultrastructural observations of the retinal pigment epithelial cells following experimental occlusion of the posterior ciliary artery in the rhesus monkey. I. Early changes of the damaged retinal pigment epithelial cells. Nihon Ganka Gakkai Zasshi. 1976;80:572–84.

    CAS  PubMed  Google Scholar 

  29. Ota M, Harayama K, Tsukahara I. Angiographic study of experimental occlusion of posterior ciliary arteries and pial vessels (author’s transl). Nihon Ganka Gakkai Zasshi. 1977;81:292–8.

    CAS  PubMed  Google Scholar 

  30. Ueno S, Harayama K, Tsukahara I. Ultrastructural observations of the retinal pigment epithelial cells following experimental occlusion of the posterior ciliary artery in the rhesus monkey. II. Mid-phase changes of the damaged retinal pigment epithelial cells. Nihon Ganka Gakkai Zasshi. 1977;81:728–42.

    CAS  PubMed  Google Scholar 

  31. Ueno S, Ohta M, Tsukahara I. Ultrastructural observations of the retinal pigment epithelial cells following experimental occlusion of the posterior ciliary artery in the rhesus monkey. III. Late changes of the damaged retinal pigment epithelial cells. Nihon Ganka Gakkai Zasshi. 1977;81:1801–13.

    CAS  PubMed  Google Scholar 

  32. Itotagawa S. Observation on the choroidal vasculature. Part 3. Recovery of blood flow in choroidal circulation after experimental occlusion of the posterior ciliary arteries (author’s transl). Nihon Ganka Gakkai Zasshi. 1979;83:2132–41.

    CAS  PubMed  Google Scholar 

  33. Matsunaga H, Andoh A, Matsubara T, Fukushima I, Takahashi K, Ohkuma H, et al. Indocyanine green infrared fluorescence angiography and vascular cast–preparation in experimental choroidal circulatory disturbance. Nihon Ganka Gakkai Zasshi. 1996;100:201–7.

    CAS  PubMed  Google Scholar 

  34. Matsunaga H, Andou A, Matsubara T, Fukushima I, Takahashi K, Ohkuma H, et al. Indocyanine green infrared fluorescence angiography and histopathological correlation in experimental choroidal circulatory disturbance. Report 1. Nihon Ganka Gakkai Zasshi. 1997;101:12–8.

    CAS  PubMed  Google Scholar 

  35. Matsunaga H, Ando A, Matsubara T, Fukushima I, Takahashi K, Ohkuma H, et al. Indocyanine green infrared fluorescence angiography and histopathological correlation in experimental choroidal circulatory disturbance. Report 2. Nihon Ganka Gakkai Zasshi. 1997;101:127–33.

    CAS  PubMed  Google Scholar 

  36. Cogan DG. Neurology of the visual system. Springfield: Charles C. Thomas; 1966. p. 137, 173, 185–8.

    Google Scholar 

  37. Henkind P, Charles NC, Pearson J. Histopathology of ischemic optic neuropathy. Am J Ophthalmol. 1970;69:78–90.

    CAS  PubMed  Google Scholar 

  38. MacMichael IM, Cullen JF. Pathology of ischaemic optic neuropathy. In: Cant JS, editor. Proceedings, 2nd William Mackenzie Symposium on the optic nerve. London: Kimpton; 1972. p. 108–16.

    Google Scholar 

  39. Hinzpeter EN, Naumann G. Ischemic papilledema in giant-cell arteritis. Mucopolysaccharide deposition with normal intraocular pressure. Arch Ophthalmol. 1976;94:624–8.

    CAS  PubMed  Google Scholar 

  40. Anderson DR, Davis EB. Retina and optic nerve after posterior ciliary artery occlusion. An experimental study in squirrel monkeys. Arch Ophthalmol. 1974;92:422–6.

    CAS  PubMed  Google Scholar 

  41. McLeod D, Marshall J, Kohner EM. Role of axoplasmic transport in the pathophysiology of ischaemic disc swelling. Br J Ophthalmol. 1980;64:247–61.

    PubMed Central  CAS  PubMed  Google Scholar 

  42. Radius RL. Optic nerve fast axonal transport abnormalities in primates. Occurrence after short posterior ciliary artery occlusion. Arch Ophthalmol. 1980;98:2018–22.

    CAS  PubMed  Google Scholar 

  43. Ellenberger Jr C. Ischemic optic neuropathy as a possible early complication of vascular hypertension. Am J Ophthalmol. 1979;88:1045–51.

    PubMed  Google Scholar 

  44. Hayreh SS. Anterior ischaemic optic neuropathy. I Terminology and pathogenesis. Br J Ophthalmol. 1974;58:955–63.

    PubMed Central  CAS  PubMed  Google Scholar 

  45. Hayreh SS. Segmental nature of the choroidal vasculature. Br J Ophthalmol. 1975;59:631–48.

    PubMed Central  CAS  PubMed  Google Scholar 

  46. Simoens P. In vivo and in vitro study of experimental occlusion of choroidal and retinal blood vessels in the miniature pig. Verh K Acad Geneeskd Belg. 1993;55:319–75.

    CAS  PubMed  Google Scholar 

  47. Meadows SP. Temporal arteritis and the loss of vision. Trans Ophthalmol Soc U K. 1954;74:13–24.

    Google Scholar 

  48. Rödenhauser JH. On pathologic-anatomical eye changes in generalized giant cell arteritis. Klin Monatsbl Augenheilkd. 1964;145:414–29.

    Google Scholar 

  49. Crompton MR. The visual changes in temporal (giant-cell) arteritis. Report of a case with autopsy findings. Brain. 1959;82:377–90.

    CAS  PubMed  Google Scholar 

  50. Cooke WT, Cloake PCP, Govan ADT, Colbeck JC. Temporal arteritis: a generalized vascular disease. Q J Med. 1946;15:47–75.

    CAS  PubMed  Google Scholar 

  51. Cardell BS, Hanley T. A fatal case of giant-cell or temporal arteritis. J Pathol Bacteriol. 1951;63:587–97.

    CAS  PubMed  Google Scholar 

  52. Greenfield JG. A case of giant-celled arteritis. Proc R Soc Med. 1951;44:855–7.

    Google Scholar 

  53. Kreibig W. Opticomalacia caused by vascular occlusion in the retrobulbar portion of optic nerves. Klin Monbl Augenheilkd Augenarztl Fortbild. 1953;122:719–31.

    CAS  PubMed  Google Scholar 

  54. Heptinstall RH, Porter KA, Barkley H. Giant-cell (temporal) arteritis. J Pathol Bacteriol. 1954;67:507–19.

    CAS  PubMed  Google Scholar 

  55. Spencer WH, Hoyt WF. A fatal case of giant-cell arteritis (Temporal or cranial arteritis) with ocular involvement. Arch Ophthalmol. 1960;64:862–7.

    Google Scholar 

  56. Seitz R. On the pathogenesis of occlusion of the retinal arteries. Ber Zusammenkunft Dtsch Ophthalmol Ges. 1961;64:321–7.

    CAS  PubMed  Google Scholar 

  57. Cullen JF. Occult temporal arteritis. Trans Ophthalmol Soc UK. 1963;83:725–36.

    CAS  PubMed  Google Scholar 

  58. Manschot WA. A fatal case of temporal arteritis with ocular symptoms. Ophthalmologica. 1965;149:121–30.

    CAS  PubMed  Google Scholar 

  59. Wolter JR, Phillips RL. Secondary glaucoma in cranial arteritis. Am J Ophthalmol. 1965;59:625–34.

    CAS  PubMed  Google Scholar 

  60. MacFaul PA. Ciliary artery involvement in giant cell arteritis. Br J Ophthalmol. 1967;51:505–12.

    PubMed Central  CAS  PubMed  Google Scholar 

  61. Knox DL, Duke JR. Slowly progressive ischemic optic neuropathy. A clinicopathologic case report. Trans Am Acad Ophthalmol Otolaryngol. 1971;75:1065–8.

    CAS  PubMed  Google Scholar 

  62. Hayreh SS. Anterior ischaemic optic neuropathy. II. Fundus on ophthalmoscopy and fluorescein angiography. Br J Ophthalmol. 1974;58:964–80.

    PubMed Central  CAS  PubMed  Google Scholar 

  63. Hayreh SS. Ischemic optic neuropathy. Int Ophthalmol. 1978;1:9–18.

    CAS  PubMed  Google Scholar 

  64. Hayreh SS. Anterior ischemic optic neuropathy. Arch Neurol. 1981;38:675–8.

    CAS  PubMed  Google Scholar 

  65. Hayreh SS. Inter-individual variation in blood supply of the optic nerve head. Its importance in various ischemic disorders of the optic nerve head, and glaucoma, low-tension glaucoma and allied disorders. Doc Ophthalmol. 1985;59:217–46.

    CAS  PubMed  Google Scholar 

  66. Hayreh SS. Anterior ischaemic optic neuropathy. Differentiation of arteritic from non-arteritic type and its management. Eye (Lond). 1990;4(Pt 1):25–41.

    Google Scholar 

  67. Hayreh SS, Podhajsky PA, Zimmerman B. Ocular manifestations of giant cell arteritis. Am J Ophthalmol. 1998;125:509–20.

    CAS  PubMed  Google Scholar 

  68. Hayreh SS, Podhajsky PA, Zimmerman B. Occult giant cell arteritis: ocular manifestations. Am J Ophthalmol. 1998;125:521–6, 893.

    CAS  PubMed  Google Scholar 

  69. Hayreh SS. Ischemic optic neuropathy. Prog Retin Eye Res. 2009;28:34–62.

    PubMed  Google Scholar 

  70. Hayreh SS. Ischemic optic neuropathies. Heidelberg: Springer; 2011.

    Google Scholar 

  71. Hayreh SS, Servais GE, Virdi PS. Fundus lesions in malignant hypertension. VI Hypertensive choroidopathy. Ophthalmology. 1986;93:1383–400.

    CAS  PubMed  Google Scholar 

  72. Kishi S, Tso MO, Hayreh SS. Fundus lesions in malignant hypertension I. A pathologic study of experimental hypertensive choroidopathy. Arch Ophthalmol. 1985;103:1189–97.

    CAS  PubMed  Google Scholar 

  73. Amalric P. Acute choroidal ischaemia. Trans Ophthalmol Soc U K. 1971;91:305–22.

    CAS  PubMed  Google Scholar 

  74. Fastenberg DM, Fetkenhour CL, Choromokos E, Shoch DE. Choroidal vascular changes in toxemia of pregnancy. Am J Ophthalmol. 1980;89:362–8.

    CAS  PubMed  Google Scholar 

  75. Raymond LA, Sacks JG, Choromokos E, Khodadad G. Short posterior ciliary artery insufficiency with hyperthermia (Uhthoff’s symptom). Am J Ophthalmol. 1980;90:619–23.

    CAS  PubMed  Google Scholar 

  76. Mames RN, Snady-McCoy L, Guy J. Central retinal and posterior ciliary artery occlusion after particle embolization of the external carotid artery system. Ophthalmology. 1991;98:527–31.

    CAS  PubMed  Google Scholar 

  77. Sribhargava N, Harsha K, Prasad S, Shetty BK. Amalric sign and central retinal artery with lateral posterior ciliary artery occlusion. Indian J Ophthalmol. 2009;57:403–4.

    PubMed Central  PubMed  Google Scholar 

  78. Bullock JD, Jampol LM, Fezza AJ. Two cases of orbital phycomycosis with recovery. Am J Ophthalmol. 1974;78:811–5.

    CAS  PubMed  Google Scholar 

  79. Jampol LM, Lahov M, Albert DM, Craft J. Ocular clinical findings and basement membrane changes in Goodpasture’s syndrome. Am J Ophthalmol. 1975;79:452–63.

    CAS  PubMed  Google Scholar 

  80. Harrison SM, Frenkel M, Grossman BJ, Matalon R. Retinopathy in childhood dermatomyositis. Am J Ophthalmol. 1973;76:786–90.

    CAS  PubMed  Google Scholar 

  81. Dizon RV, Jampol LM, Goldberg MF, Juarez C. Choroidal occlusive disease in sickle cell hemoglobinopathies. Surv Ophthalmol. 1979;23:297–306.

    CAS  PubMed  Google Scholar 

  82. Cogan DG. Ocular involvement in disseminated intravascular coagulopathy. Arch Ophthalmol. 1975;93:1–8.

    CAS  PubMed  Google Scholar 

  83. Makino S, Takezawa M, Sato Y. A case of incomplete central retinal artery occlusion associated with short posterior ciliary artery occlusion. Case Reports in Ophthalmological Medicine [Internet]. 2013; doi:10.1155/2013/105653. [4 p.]. Available from: http://www.hindawi.com/journals/criopm/2013/105653/.

  84. Matsuo T, Fujiwara H, Gobara H, Mimura H, Kanazawa S. Central retinal and posterior ciliary artery occlusion after intralesional injection of sclerosant to glabellar subcutaneous hemangioma. Cardiovasc Intervent Radiol. 2009;32:341–6.

    PubMed  Google Scholar 

  85. Park SH, Sun HJ, Choi KS. Sudden unilateral visual loss after autologous fat injection into the nasolabial fold. Clin Ophthalmol. 2008;2:679–83.

    PubMed Central  PubMed  Google Scholar 

  86. Shin H, Lemke BN, Stevens TS, Lim MJ. Posterior ciliary-artery occlusion after subcutaneous silicone-oil injection. Ann Ophthalmol. 1988;20:342–4.

    CAS  PubMed  Google Scholar 

  87. Lemaitre-Labilloy C, Bodaghi B, Cassoux N, Lehoang P. Acute choroidal closure caused by hemodialysis accident in an amyloidosic patient. Graefes Arch Clin Exp Ophthalmol. 2006;244:758–60.

    PubMed  Google Scholar 

  88. Jampol LM, Goldbaum M, Rosenberg M, Bahr R. Ischemia of ciliary arterial circulation from ocular compression. Arch Ophthalmol. 1975;93:1311–7.

    CAS  PubMed  Google Scholar 

  89. Carr RE, Siegel IM. Unilateral retinitis pigmentosa. Arch Ophthalmol. 1973;90:21–6.

    CAS  PubMed  Google Scholar 

  90. Goldbaum MH, Galinos SO, Apple D, Asdourian GK, Nagpal K, Jampol L, et al. Acute choroidal ischemia as a complication of photocoagulation. Arch Ophthalmol. 1976;94:1025–35.

    CAS  PubMed  Google Scholar 

  91. Bacin F, Menerath JM. Posterior ciliary artery occlusion after krypton photocoagulation of subretinal neovessels. Bull Soc Ophtalmol Fr. 1988;88:647–9.

    CAS  PubMed  Google Scholar 

  92. Brancato R, Menchini U, Pece A, Bandello F. Occlusion of the posterior ciliary arteries after surgery for retinal detachment. Bull Mem Soc Fr Ophtalmol. 1985;96:258–60.

    CAS  PubMed  Google Scholar 

  93. Chiquet C, Germain P, Burillon C, Coudry-Vergne D, Perez M, Paupert-Ravault M, et al. Multifocal choroiditis associated with herpes zoster ophthalmicus. Apropos of a case. J Fr Ophtalmol. 1996;19:712–5.

    CAS  PubMed  Google Scholar 

  94. Luo QL, Orcutt JC, Seifter LS. Orbital mucormycosis with retinal and ciliary artery occlusions. Br J Ophthalmol. 1989;73:680–3.

    PubMed Central  CAS  PubMed  Google Scholar 

  95. Iida T, Spaide RF, Kantor J. Retinal and choroidal arterial occlusion in Wegener’s granulomatosis. Am J Ophthalmol. 2002;133:151–2.

    PubMed  Google Scholar 

  96. Bird AC, Anderson J, Fuglsang H. Morphology of posterior segment lesions of the eye in patients with onchocerciasis. Br J Ophthalmol. 1976;60:2–20.

    PubMed Central  CAS  PubMed  Google Scholar 

  97. Diamond JG, Kaplan HJ. Uveitis: effect of vitrectomy combined with lensectomy. Ophthalmology. 1979;86:1320–9.

    CAS  PubMed  Google Scholar 

  98. Rosenblum PD, Michels RG, Stark WJ, Taylor HR. Choroidal ischemia after extracapsular cataract extraction by phacoemulsification. Retina. 1981;1:263–70.

    CAS  PubMed  Google Scholar 

  99. Hayreh SS. Choroidal ischemia after extra capsular cataract extraction by phacoemulsification. Retina. 1982;2:191–3.

    CAS  PubMed  Google Scholar 

  100. Rodriguez A, Rodriguez FJ, Betancourt F. Presumed occlusion of posterior ciliary arteries following central retinal vein decompression surgery. Arch Ophthalmol. 1994;112:54–6.

    CAS  PubMed  Google Scholar 

  101. Hayreh SS. Choroidal arterial occlusive disorders. Doc Ophthal Proc Sem. 1976;9:211–27.

    Google Scholar 

  102. Hayreh SS. Acute occlusive disorders of the choroidal vasculature. Int Ophthalmol. 1983;6:139–48.

    CAS  PubMed  Google Scholar 

  103. Hepburn ML. Inflammatory and vascular diseases of the choroid. Trans Ophthalmol Soc U K. 1912;32:361–86.

    Google Scholar 

  104. Hepburn ML. The Doyne Memorial Lencture: the role played by the pigment and visual fields in the diagnosis of diseases of the fundus. Trans Ophthalmol Soc U K. 1935;55:434–77.

    Google Scholar 

  105. Foulds WS, Lee WR, Taylor WO. Clinical and pathological aspects of choroidal ischaemia. Trans Ophthalmol Soc U K. 1971;91:323–41.

    CAS  PubMed  Google Scholar 

  106. Hayreh SS. The choriocapillaris. Albrecht von Graefes Arch Klin Exp Ophthalmol. 1974;192:165–79.

    CAS  PubMed  Google Scholar 

  107. Klien BA. Ischemic infarcts of the choroid (Elschinig spots). A cause of retinal separation in hypertensive disease with renal insufficiency. A clinical and histopathologic study. Am J Ophthalmol. 1968;66:1069–74.

    CAS  PubMed  Google Scholar 

  108. Stern WH, Ernest JT. Microsphere occlusion of the choriocapillaris in rhesus monkeys. Am J Ophthalmol. 1974;78:438–48.

    CAS  PubMed  Google Scholar 

  109. Gass JD. Acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol. 1968;80:177–85.

    CAS  PubMed  Google Scholar 

  110. Deutman AF, Lion F. Choriocapillaris nonperfusion in acute multifocal placoid pigment epitheliopathy. Am J Ophthalmol. 1977;84:652–7.

    CAS  PubMed  Google Scholar 

  111. Deutman AF. Acute multifocal ischaemic choroidopathy and the choriocapillaris. Int Ophthalmol. 1983;6:155–60.

    CAS  PubMed  Google Scholar 

  112. Young NJ, Bird AC, Sehmi K. Pigment epithelial diseases with abnormal choroidal perfusion. Am J Ophthalmol. 1980;90:607–18.

    CAS  PubMed  Google Scholar 

  113. Holt WS, Regan CD, Trempe C. Acute posterior multifocal placoid pigment epitheliopathy. Am J Ophthalmol. 1976;81:403–12.

    CAS  PubMed  Google Scholar 

  114. Sigelman J, Behrens M, Hilal S. Acute posterior multifocal placoid pigment epitheliopathy associated with cerebral vasculitis and homonymous hemianopia. Am J Ophthalmol. 1979;88:919–24.

    CAS  PubMed  Google Scholar 

  115. Tsang BK-T, Chauhan DS, Haward R, Whiteman I, Frayne J, McLean C. Fatal ischemic stroke complicating acute multifocal placoid pigment epitheliopathy: histopathological findings. J Neuroophthalmol. 2014;34:10–5.

    PubMed  Google Scholar 

  116. Priluck IA, Robertson DM, Buettner H. Acute posterior multifocal placoid pigment epitheliopathy. Urinary findings. Arch Ophthalmol. 1981;99:1560–2.

    CAS  PubMed  Google Scholar 

  117. Kirkham TH, Ffytche TJ, Sanders MD. Placoid pigment epitheliopathy with retinal vasculitis and papillitis. Br J Ophthalmol. 1972;56:875–80.

    PubMed Central  CAS  PubMed  Google Scholar 

  118. Savino PJ, Weinberg RJ, Yassin JG, Pilkerton AR. Diverse manifestations of acute posterior multifocal placoid pigment epitheliopathy. Am J Ophthalmol. 1974;77:659–62.

    CAS  PubMed  Google Scholar 

  119. Jacklin HN. Acute posterior multifocal placoid pigment epitheliopathy and thyroiditis. Arch Ophthalmol. 1977;95:995–7.

    CAS  PubMed  Google Scholar 

  120. Hyvarinen L, Maumenee AE, George T, Weinstein GW. Fluorescein angiography of the choriocapillaris. Am J Ophthalmol. 1969;67:653–66.

    CAS  PubMed  Google Scholar 

  121. Hamilton AM, Bird AC. Geographical choroidopathy. Br J Ophthalmol. 1974;58:784–97.

    PubMed Central  CAS  PubMed  Google Scholar 

  122. De Lay JJ. Fluoro-angiographic study of the choroid in man. Doc Ophthalmol. 1978;45:1–217.

    Google Scholar 

  123. Oosterhuis JA. The architecture of the choroidal vascular system in clinical ophthalmology. In: Shimizu K, Oosterhuis JA, editors. Acta XXIII Concilium Ophthalmologicum, Kyoto, 1978. Part 1. Amsterdam: Excerpta Medica; 1979. p. 242–8.

    Google Scholar 

  124. Uyama M, Itotagawa S, Uraguchi K, Ohkuma H, Miki K, Koshibu A. Pathology of choroidal circulatory disturbance. Part 2. Deprivation of the choroidal blood flow and its recovery, an experimental study (author’s transl). Nihon Ganka Gakkai Zasshi. 1980;84:1910–23.

    CAS  PubMed  Google Scholar 

  125. Hayreh SS. Acute choroidal ischaemia. Trans Ophthalmol Soc U K. 1980;100:400–7.

    CAS  PubMed  Google Scholar 

  126. Adhi M, Lau M, Liang MC, Waheed NK, Duker JS. Analysis of the thickness and vascular layers of the choroid in eyes with geographic atrophy using spectral-domain optical coherence tomography. Retina. 2014;34:306–12.

    PubMed  Google Scholar 

  127. Friedman E, Smith TR, Kuwabara T, Beyer CK. Choroidal vascular patterns in hypertension. Arch Ophthalmol. 1964;71:842–50.

    CAS  PubMed  Google Scholar 

  128. Wright BE, Bird AC, Hamilton AM. Placoid pigment epitheliopathy and Harada’s disease. Br J Ophthalmol. 1978;62:609–21.

    PubMed Central  CAS  PubMed  Google Scholar 

  129. Hayreh SS. Choroidal ischemia. Retina. 1982;2:191–2.

    CAS  PubMed  Google Scholar 

  130. Parrish R, Gass JD, Anderson DR. Outer retina ischemic infarction–a newly recognized complication of cataract extraction and closed vitrectomy. Part 2. An animal model. Ophthalmology. 1982;89:1472–7.

    CAS  PubMed  Google Scholar 

  131. Amalric P. The choriocapillaris in the macular area. Clinical and angiographic study. Int Ophthalmol. 1983;6:149–53.

    CAS  PubMed  Google Scholar 

  132. Hayreh SS. Macular lesions secondary to choroidal vascular disorders. Int Ophthalmol. 1983;6:161–70.

    CAS  PubMed  Google Scholar 

  133. Hayreh SS. In vivo choroidal circulation and its watershed zones. Eye (Lond). 1990;4(Pt 2):273–89.

    Google Scholar 

  134. Chen JC, Fitzke FW, Pauliekhoff D, Bird AC. Poor choroidal perfusion is a cause of visual morbidity in age-related macular degeneration [abstract]. Invest Ophthalmol Vis Sci. 1989;30(Suppl):153.

    Google Scholar 

  135. Ross RD, Barofsky JM, Cohen G, Baber WB, Palao SW, Gitter KA. Presumed macular choroidal watershed vascular filling, choroidal neovascularization, and systemic vascular disease in patients with age-related macular degeneration. Am J Ophthalmol. 1998;125:71–80.

    CAS  PubMed  Google Scholar 

  136. Hayreh SS. Controversies on submacular choroidal circulation. Ophthalmologica. 1981;183:11–9.

    CAS  PubMed  Google Scholar 

  137. Kornzweig AL. Changes in the choriocapillaris associated with senile macular degeneration. Ann Ophthalmol. 1977;9(753–6):59–62.

    Google Scholar 

  138. Sarks SH. Ageing and degeneration in the macular region: a clinico-pathological study. Br J Ophthalmol. 1976;60:324–41.

    PubMed Central  CAS  PubMed  Google Scholar 

  139. Sarks SH. Changes in the region of the choriocapillaris in ageing and degeneration. In: Shimizu K, Oosterhuis JA, editors. Acta XXIII Concilium Ophthalmologicum, Kyoto, 1978. Part 1. Amsterdam: Excerpta Medica; 1979. p. 228–38.

    Google Scholar 

  140. Grunwald JE, Hariprasad SM, DuPont J, Maguire MG, Fine SL, Brucker AJ, et al. Foveolar choroidal blood flow in age-related macular degeneration. Invest Ophthalmol Vis Sci. 1998;39:385–90.

    CAS  PubMed  Google Scholar 

  141. Grunwald JE, Metelitsina TI, Dupont JC, Ying GS, Maguire MG. Reduced foveolar choroidal blood flow in eyes with increasing AMD severity. Invest Ophthalmol Vis Sci. 2005;46:1033–8.

    PubMed  Google Scholar 

  142. Metelitsina TI, Grunwald JE, DuPont JC, Ying GS, Brucker AJ, Dunaief JL. Foveolar choroidal circulation and choroidal neovascularization in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49:358–63.

    PubMed Central  PubMed  Google Scholar 

  143. Xu W, Grunwald JE, Metelitsina TI, DuPont JC, Ying GS, Martin ER, et al. Association of risk factors for choroidal neovascularization in age-related macular degeneration with decreased foveolar choroidal circulation. Am J Ophthalmol. 2010;150:40–7.

    PubMed Central  PubMed  Google Scholar 

  144. Hayreh SS. Submacular choroidal vascular bed watershed zones and their clinical importance. Am J Ophthalmol. 2010;150:940–1.

    PubMed  Google Scholar 

  145. Gass JD. Radial chorioretinal folds. A sign of choroidal neovascularization. Arch Ophthalmol. 1981;99:1016–8.

    CAS  PubMed  Google Scholar 

  146. Cunha-Vaz J. The blood-ocular barriers. Surv Ophthalmol. 1979;23:279–96.

    CAS  PubMed  Google Scholar 

  147. Weiter J, Fine BS. A histologic study of regional choroidal dystrophy. Am J Ophthalmol. 1977;83:741–50.

    CAS  PubMed  Google Scholar 

  148. Paton D, Duke JR. Primary familial amyloidosis. Ocular manifestations with histopathologic observations. Am J Ophthalmol. 1966;61:736–47.

    CAS  PubMed  Google Scholar 

  149. Hayreh SS. Recent advances in fluorescein fundus angiography. Br J Ophthalmol. 1974;58:391–412.

    PubMed Central  CAS  PubMed  Google Scholar 

  150. Green JL, Rabb MF. Degeneration of Bruch’s membrane and retinal pigment epithelium. Int Ophthalmol Clin. 1981;21(3):27–50.

    Google Scholar 

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  1. Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, IA, USA

    Sohan Singh Hayreh

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Hayreh, S.S. (2015). Posterior Ciliary Artery Occlusion and Choroidal Ischemia. In: Ocular Vascular Occlusive Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-12781-1_18

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