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Psychiatric Disorders as Vulnerability Factors for Nicotine Addiction: What Have We Learned from Animal Models?

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The Neuropharmacology of Nicotine Dependence

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 24))

Abstract

Epidemiological studies indicate a high prevalence of tobacco smoking in subjects with psychiatric disorders. Notably, there is a high prevalence of smoking among those with dependence to other substances, schizophrenia, mood, or anxiety disorders. It has been difficult to understand how these phenomena interact with clinical populations as it is unclear what preceded what in most of the studies. These comorbidities may be best understood by using experimental approaches in well-controlled conditions. Notably, animal models represent advantageous approaches as the parameters under study can be controlled perfectly. This review will focus on evidence collected so far exploring how behavioral effects of nicotine are modified in animal models of psychiatric conditions. Notably, we will focus on behavioral responses induced by nicotine that are relevant for its addictive potential. Despite the clinical relevance and frequency of the comorbidity between psychiatric issues and tobacco smoking, very few studies have been done to explore this issue in animals. The available data suggest that the behavioral and reinforcing effects of nicotine are enhanced in animal models of these comorbidities, although much more experimental work would be required to provide certainty in this domain.

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Acknowledgments

Funding Dr. Le Foll’s research is supported by CAMH, the Campbell Family Mental Health Research Institute, CIHR and the National Institute on Drug Abuse at the National Institutes of Health (1R21DA033515-01).

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Authors and Affiliations

  1. Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON, M5S 2S1, Canada

    Bernard Le Foll, Patricia Di Ciano & José M. Trigo

  2. Ambulatory Care and Structured Treatment Program, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON, M5S 2S1, Canada

    Bernard Le Foll

  3. Departments of Family and Community Medicine, Pharmacology, Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, Canada

    Bernard Le Foll

  4. Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada

    Enoch Ng

  5. Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON, M5V 2W8, Canada

    Bernard Le Foll

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Correspondence to Bernard Le Foll .

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  1. Ninewells Hospital, University of Dundee Medical School, Dundee, United Kingdom

    David J.K. Balfour

  2. School of Experimental Psychology, University of Bristol, Bristol, United Kingdom

    Marcus R. Munafò

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Le Foll, B., Ng, E., Di Ciano, P., Trigo, J.M. (2015). Psychiatric Disorders as Vulnerability Factors for Nicotine Addiction: What Have We Learned from Animal Models?. In: Balfour, D., Munafò, M. (eds) The Neuropharmacology of Nicotine Dependence. Current Topics in Behavioral Neurosciences, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-319-13482-6_6

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