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Indocyanine Green Fluorescence-Navigated Sentinel Node Biopsy Showed Higher Sensitivity than the Conventional Radioisotope or Blue Dye Methods: It May Help to Reduce False-Negative Sentinel Lymph Node Biopsies in Skin Cancer

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Fluorescence Imaging for Surgeons

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Abstract

Despite the use of radioisotope and blue dye to detect sentinel lymph nodes (SLNs), false-negative cases occur in approximately 5 % of melanomas. To reduce such cases, we here introduce a new lymphatic navigation method using indocyanine green (ICG). ICG fluorescence can be detected transcutaneously, and we can observe the lymph flow in real time. Moreover, maybe due to the small particles, ICG tends to accumulate in more lymph nodes than other tracers. These “occult” SLNs may explain some false-negative cases, so we recommend using ICG in addition to a conventional method to reduce the risk of overlooking such SLNs.

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Acknowledgement

We are grateful to Brian K. Purdue for his native English speaker manuscript editing.

Financial disclosure 

This work was partly supported by a National Cancer Center Research and Development Fund (23-A-22).

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Authors and Affiliations

  1. Department of Dermatology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan

    Yasuhiro Fujisawa M.D., Ph.D.

Authors
  1. Yasuhiro Fujisawa M.D., Ph.D.
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Correspondence to Yasuhiro Fujisawa M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Section of Minimally Invasive Surgery, Department of General and Vascular Surgery, The Bariatric and Metabolic Institute, Cleveland Clinic Florida, FL, USA; Oncological Surgical Division, Division of Surgical Research, Department of Surgery, Hospital de Clinicas Buenos Aires, University of Buenos Aires, Buenos Aires, Argentina

    Fernando D. Dip

  2. Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research; Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

    Takeaki Ishizawa

  3. Hepato-Biliary-Pancreatic Surgery; Department of Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan

    Norihiro Kokudo

  4. Department of General Surgery, Section of Minimally Invasive Surgery; Department of General and Vascular Surgery, The Bariatric and Metabolic Institute, Cleveland Clinic Florida, Weston, Florida, USA

    Raul J. Rosenthal

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Fujisawa, Y. (2015). Indocyanine Green Fluorescence-Navigated Sentinel Node Biopsy Showed Higher Sensitivity than the Conventional Radioisotope or Blue Dye Methods: It May Help to Reduce False-Negative Sentinel Lymph Node Biopsies in Skin Cancer. In: Dip, F., Ishizawa, T., Kokudo, N., Rosenthal, R. (eds) Fluorescence Imaging for Surgeons. Springer, Cham. https://doi.org/10.1007/978-3-319-15678-1_26

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  • DOI: https://doi.org/10.1007/978-3-319-15678-1_26

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-15677-4

  • Online ISBN: 978-3-319-15678-1

  • eBook Packages: MedicineMedicine (R0)

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