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Polycomb Proteins and their Roles in Skin Development and Regeneration

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Epigenetic Regulation of Skin Development and Regeneration

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Polycomb repressive complexes (PRC) are essential chromatin regulators that control tissue development and stem cells. While studies have revealed the functions of Polycomb proteins in embryonic stem cells and mammalian tissues, the exact mechanisms of Polycomb function largely remain to be elucidated. Here, we will discuss evidence of the essential roles of Polycomb proteins in the skin, including their roles in the control of development, wound healing and regeneration, as well as in triggering common skin diseases, including cancer and psoriasis.

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Abbreviations

BCC:

Basal cell carcinoma

cKO:

conditional knockout

E:

embryonic

EC-SC:

Epidermal cancer stem cell

EDC:

Epidermal Differentiation Complex

ESC:

Embryonic stem cell

H2AK119ub1:

histone H2A monoubiquitylation of K119

H3K27me3:

trimethylation of histone H3 at lysine (K) 27

HF-SC:

Hair follicle stem cells

KO:

knockout

Krt:

Cytokeratin

MCC:

Merkel cell carcinoma

Mx:

Matrix

ORS:

Outer root sheath

P:

Postnatal

PcG:

Polycomb group

PRC:

Polycomb repressive complex

RNAPII-S2P:

RNAPII phosphorylated on Serine 2

SC:

Stem cell

SCC:

Squamous cell carcinoma

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Acknowledgments

Katherine L. Dauber-Decker was a trainee of the NIDCR-Interdisciplinary Training Program in Systems and Developmental Biology and Birth Defects T32HD075735. Elena Ezhkova is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award numbers R01 AR063724 and R01 AR069078. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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  1. Katherine L. Dauber-Decker and Idan Cohen contributed equally to this work.

Authors and Affiliations

  1. Department of Cell, Developmental, and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Katherine L. Dauber-Decker, Idan Cohen & Elena Ezhkova

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  1. Katherine L. Dauber-Decker
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  2. Idan Cohen
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  3. Elena Ezhkova
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Correspondence to Elena Ezhkova .

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Editors and Affiliations

  1. Centre for Skin Sciences, University of Bradford, Bradford, UK

    Vladimir A. Botchkarev

  2. Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Sarah E. Millar

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Dauber-Decker, K.L., Cohen, I., Ezhkova, E. (2018). Polycomb Proteins and their Roles in Skin Development and Regeneration. In: Botchkarev, V., Millar, S. (eds) Epigenetic Regulation of Skin Development and Regeneration. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-16769-5_3

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