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Individual Food Clusters Excess and Low-Grade Inflammation in Pregnancy

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Metabolic Syndrome and Complications of Pregnancy
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Abstract

Pregnancy expresses a balance between tolerance and inflammation. The excessive and recurrent intake of similar food clusters and the excessive production of corresponding IgG antibodies could start a cause-effect reaction and an increase of inflammatory mediators. The evaluation of BAFF and PAF could allow to measure levels of inflammation related to the personal profile of food consumption and modulate specific dietary changes. The best nutritional profile for pregnancy should probably be the most varied as possible, within the criteria of major food pyramids adopted for millennia by different macro-ethnicities.

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References

  1. Singh M, Chaudhry P, Asselin E. Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors. J Endocrinol. 2011;210:5–14. doi:10.1530/JOE-10-0461.

    Article  CAS  PubMed  Google Scholar 

  2. Hemberger M. Immune balance at the foeto-maternal interface as the fulcrum of reproductive success. J Reprod Immunol. 2013;97:36–42. doi:10.1016/j.jri.2012.10.006.

    Article  PubMed  Google Scholar 

  3. McMaster MT, Newton RC, Dey SK, Andrews GK. Activation and distribution of inflammatory cells in the mouse uterus during the preimplantation period. J Immunol. 1992;148:1699–705.

    CAS  PubMed  Google Scholar 

  4. Robb L, Li R, Hartley L, et al. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Nat Med. 1998;4:303–8.

    Article  CAS  PubMed  Google Scholar 

  5. Stewart CL, Kaspar P, Brunet LJ, et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature. 1992;359:76–9. doi:10.1038/359076a0.

    Article  CAS  PubMed  Google Scholar 

  6. Erlebacher A, Zhang D, Parlow AF, Glimcher LH. Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system. J Clin Invest. 2004;114:39–48. doi:10.1172/JCI20645.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Cui L-L, Yang G, Pan J, Zhang C. Tumor necrosis factor α knockout increases fertility of mice. Theriogenology. 2011;75:867–76. doi:10.1016/j.theriogenology.2010.10.029.

    Article  CAS  PubMed  Google Scholar 

  8. Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med. 2001;345:1400–8. doi:10.1056/NEJMra000763.

    Article  CAS  PubMed  Google Scholar 

  9. Solano ME, Jago C, Pincus MK, Arck PC. Highway to health; or how prenatal factors determine disease risks in the later life of the offspring. J Reprod Immunol. 2011;90:3–8. doi:10.1016/j.jri.2011.01.023.

    Article  PubMed  Google Scholar 

  10. Arck PC, Hecher K. Fetomaternal immune cross-talk and its consequences for maternal and offspring's health. Nat Med. 2013;19:548–56. doi:10.1038/nm.3160.

    Article  CAS  PubMed  Google Scholar 

  11. Hartwig IRV, Pincus MK, Diemert A, et al. Sex-specific effect of first-trimester maternal progesterone on birthweight. Hum Reprod. 2013;28:77–86. doi:10.1093/humrep/des367.

    Article  CAS  PubMed  Google Scholar 

  12. Arck PC, Rücke M, Rose M, et al. Early risk factors for miscarriage: a prospective cohort study in pregnant women. Reprod Biomed Online. 2008;17:101–13.

    Article  PubMed  Google Scholar 

  13. Bach J-F. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med. 2002;347:911–20. doi:10.1056/NEJMra020100.

    Article  PubMed  Google Scholar 

  14. Brannon PM. Vitamin D and adverse pregnancy outcomes: beyond bone health and growth. Proc Nutr Soc. 2012;71:205–12. doi:10.1017/S0029665111003399.

    Article  CAS  PubMed  Google Scholar 

  15. Sherman PW, Flaxman SM. Nausea and vomiting of pregnancy in an evolutionary perspective. Am J Obstet Gynecol. 2002;186:S190–7. doi:10.1067/mob.2002.122593.

    Article  PubMed  Google Scholar 

  16. Ligaarden SC, Lydersen S, Farup PG. IgG and IgG4 antibodies in subjects with irritable bowel syndrome: a case control study in the general population. BMC Gastroenterol. 2012;12:166. doi:10.1186/1471-230X-12-166.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Speciani AF, Piuri G, Ferrazzi E. IgG levels to food correlate with nutritional exposure to food antigens but a methodological weakness of this research prevents the recognition of yeast- related foods as a possible cause of Irritable Bowel Syndrome (IBS). Comment to IgG and IgG4 antibodies in subjects with irritable bowel syndrome: a case control study in the general population. Published on 2014/02/20. BMC Gastroenterol. 2012;12:166. doi:10.1186/1471-230X-12-166. http://www.biomedcentral.com/1471-230X/12/166/comments

  18. Wisniewski J, Agrawal R, Woodfolk JA. Mechanisms of tolerance induction in allergic disease: integrating current and emerging concepts. Clin Exp Allergy. 2013;43:164–76. doi:10.1111/cea.12016.

    Article  CAS  PubMed  Google Scholar 

  19. van der Neut Kolfschoten M, Schuurman J, Losen M, et al. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science. 2007;317:1554–7. doi:10.1126/science.1144603.

    Article  PubMed  Google Scholar 

  20. Finkelman FD. Anaphylaxis: lessons from mouse models. J Allergy Clin Immunol. 2007;120:506–15– quiz 516–7. doi: 10.1016/j.jaci.2007.07.033.

  21. Khodoun MV, Strait R, Armstrong L, et al. Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis. Proc Natl Acad Sci U S A. 2011;108:12413–8. doi:10.1073/pnas.1105695108.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Piuri G, Soriano J, Speciani MC, Speciani AF. B cell activating factor (BAFF) and platelet activating factor (PAF) could both be markers of non-IgE-mediated reactions. Clin Transl Allergy. 2013;3:O5. doi:10.1016/j.jaci.2007.07.033.

    Article  PubMed Central  Google Scholar 

  23. Piuri G, Bulfoni C, Mastricci AL, Speciani AF, Ferrazzi E. Two innovative inflammation biomarkers for the measurement of inflammation in pregnancy. Paper presented at the 24th European Congress of Perinatal Medicie (ECPM), Florence, 4–7 June 2014.

    Google Scholar 

  24. Speciani AF, Soriano J, Speciani MC, Piuri G. Five great food clusters of specific IgG for 44 common food antigens. A new approach to the epidemiology of food allergy. Clin Transl Allergy. 2013;3:P67. doi:10.1186/2045-7022-3-S3-P67.

    PubMed Central  Google Scholar 

  25. Speciani AF, Piuri G, Soriano J, Ferrazzi E. A larger study of food-related IgG confirms the possible new epidemiological approach to non-IgE-mediated reactions and suggests five great food clusters. Paper presented at 3rd Food Allergy and Anaphylaxis Meeting (FAAM), Dublin, 9–11 Oct 2014.

    Google Scholar 

  26. Speciani AF. Measuring biomarkers for an innovative food personal profile. Lesson at 3rd international congress science in nutrition “anti-inflammation, quality of life and sport in nutrition.” Milan 14–15 March 2014.

    Google Scholar 

  27. Roduit C, Frei R, Depner M, et al. Increased food diversity in the first year of life is inversely associated with allergic diseases. J Allergy Clin Immunol. 2014;133:1056–64. doi:10.1016/j.jaci.2013.12.1044.

    Article  PubMed  Google Scholar 

  28. Nwaru BI, Takkinen H-M, Kaila M, et al. Food diversity in infancy and the risk of childhood asthma and allergies. J Allergy Clin Immunol. 2014;133:1084–91. doi:10.1016/j.jaci.2013.12.1069.

    Article  PubMed  Google Scholar 

  29. Greer FR, Sicherer SH, Burks AW, Committee on Nutrition and Section on Allergy and Immunology. Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Timing of Introduction of Complementary Foods, and Hydrolyzed Formulas. Pediatrics. 2008;121:183–91. doi:10.1542/peds. 2007-3022.

    Article  PubMed  Google Scholar 

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Correspondence to Gabriele Piuri MD, PhD .

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Piuri, G. (2015). Individual Food Clusters Excess and Low-Grade Inflammation in Pregnancy. In: Ferrazzi, E., Sears, B. (eds) Metabolic Syndrome and Complications of Pregnancy. Springer, Cham. https://doi.org/10.1007/978-3-319-16853-1_2

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  • DOI: https://doi.org/10.1007/978-3-319-16853-1_2

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-16852-4

  • Online ISBN: 978-3-319-16853-1

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