Abstract
Mouse models provide important resources for many areas of vision research, pertaining to retinal development, retinal function and retinal disease. The Translational Vision Research Models (TVRM) program uses chemical mutagenesis to generate new mouse models for vision research. In this chapter, we report the identification of mouse models for Grm1, Grk1 and Lrit3. Each of these is characterized by a primary defect in the electroretinogram. All are available without restriction to the research community.
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References
Ayoub MA, Angelicheva D, Vile D et al (2012) Deleterious GRM1 mutations in schizophrenia. PLoS ONE 7:e32849
Chen CK, Burns ME, Spencer M et al (1999) Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A 96:3718–3722
Cideciyan AV, Zhao X, Nielsen L et al (1998) Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc Natl Acad Sci U S A 95:328–333
Conquet F, Bashir ZI, Davies CH et al (1994) Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature 372:237–243
Conti V, Aghaie A, Cilli M et al (2006) crv4, a mouse model for human ataxia associated with kyphoscoliosis caused by an mRNA splicing mutation of the metabotropic glutamate receptor 1 (Grm1). Int J Mol Med 18:593–600
Fan J, Sakurai K, Chen CK et al (2010) Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism. J Neurosci 30:2496–2503
Hawes NL, Smith RW, Chang B et al (1999) Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22
Hawes NL, Chang B, Hageman GS et al (2000) Retinal degeneration 6 (rd6): a new mouse model for human retinitis punctata albescens. Invest Ophthalmol Vis Sci 41:3149–3157
Mendez A, Burns ME, Roca A et al (2000) Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites. Neuron 28:153–164
Menke A, Sämann P, Kloiber S et al (2012) Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes. Psychoneuroendocrinol 37:565–575
Neuillé M, El Shamieh S, Orhan E et al (2014) Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB). PLoS ONE 9:e90342
Pardue MT, Peachey NS (2014) Mouse b-wave mutants. Doc Ophthalmol 128:77–89
Peachey NS, Pearring JN, Bojang P Jr et al (2012) Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation. J Neurophysiol 108:2442–2451
Sachs AJ, Schwendinger JK, Yang AW et al (2007) The mouse mutants recoil wobbler and nmf373 represent a series of Grm1 mutations. Mamm Genome 18:749–756
Won J, Shi LY, Hicks W et al (2011) Mouse models for vision research. J Ophthalmol 2011:391384
Won J, Shi LY, Hicks W et al (2012) Translational vision research models program. Adv Exp Med Biol 723:391–397
Yamamoto S, Sippel KC, Berson EL, Dryja TP (1997) Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nat Genet 15:175–178
Yu M, Sturgill-Short G, Ganapathy P et al (2012) Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia. Exp Eye Res 96:124–131
Zeitz C, Jacobson SG, Hamel CP et al (2013) Whole-exome sequencing identifies LRIT3 mutations as a cause of autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet 92:67–75
Acknowledgments
This work was supported by NIH grants (R01EY16501; P30CA34196), Foundation Fighting Blindness, VA Medical Research Service, and Research to Prevent Blindness.
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Charette, J. et al. (2016). A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects. In: Bowes Rickman, C., LaVail, M., Anderson, R., Grimm, C., Hollyfield, J., Ash, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 854. Springer, Cham. https://doi.org/10.1007/978-3-319-17121-0_24
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DOI: https://doi.org/10.1007/978-3-319-17121-0_24
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