Abstract
The main goal of this chapter is to show how specific DNA and RNA modifications and defects change the molecular electronic properties and how electronic state measurements can be used for oligonucleotide modifications and defect sensing. We also show that specific electronic states in DNA/Hg complexes play an important role in sensing the Hg presence in the environment. This chapter encompasses different concepts and methods showing the coherence between the structure, composition, and electronic properties of DNA and RNA.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Genereux JC, Wuerth SM, Barton JK (2011) Single-step charge transport through DNA over long Distances. J Am Chem Soc 133:3863–3868
Giese B (2002) Long-distance electron transfer through DNA. Annu Rev Biochem 71:51–70
Guo L et al (2009) Highly sensitive fluorescent sensor for mercury ion based on photoinduced charge transfer between fluorophore and π-stacked T–Hg(II)–T base pairs. Talanta 79:775–779
Kratochvílová I, Král K, Bunček M et al (2008) Conductivity of natural and modified DNA measured by scanning tunneling microscopy. The effect of sequence, charge and stacking. Biophys Chem 138:3–10
Kratochvílová I, Todorciuc T, Král K et al (2010) Charge transport in DNA oligonucleotides with various base-pairing patterns. J Phys Chem B 114:5196–5205
Kratochvílová I, Vala M, Weiter M et al (2013) Charge transfer through DNA/DNA duplexes and DNA/RNA hybrids: complex theoretical and experimental studies. Biophys Chem 180:127–134
Kratochvílová B, Golan M, Vala M et al (2014) Theoretical and experimental study of charge transfer through DNA: impact of mercury mediated T-Hg-T base pair. J Phys Chem B 22:5374–5381
Matsui T, Shigeta Y, Hirao K (2007) Multiple proton-transfer reactions in DNA base pairs by coordination of Pt complex. J Phys Chem B 111:1176–1181
Pamela A, Sontz PA, Muren NB et al (2012) DNA charge transport for sensing and signaling. Acc Chem Res 45:1792–1800
Porath D, Bezryadin A, Vries S et al (2000) Direct measurement of electrical transport through DNA molecules. Nature 403:635–638
Rasheed PA, Sandhyarani N (2014) Femtomolar level detection of BRCA1 gene using a gold nanoparticle labeled sandwich type DNA sensor. Colloids Surf B Biointerfaces 117:7–13
Tang YL, He F, Yu MH (2006) A reversible and highly selective fluorescent sensor for mercury(II) using poly (thiophene)s that contain thymine moieties. Macromol Rapid Commun 27:389–392
Taniguchi M, Kawai T (2006) Review. DNA Electronics Phys E 33:1–12
Wagenknecht HA (2005) Charge transfer process in DNA: from mechanism to application. Germany, ISBN: 978-3-527-31085-2
Wang Z, Zhang DQ, Zhu DB (2005) A sensitive and selective “turn on” fluorescent chemosensor for Hg(II) ion based on a new pyrene-thymine dyad. Anal Chim Acta 549:10–13
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Kratochvílová, I. (2015). DNA and RNA Electronic Properties for Molecular Modifications and Environmental State Diagnostics. In: Erdmann, V., Jurga, S., Barciszewski, J. (eds) RNA and DNA Diagnostics. RNA Technologies. Springer, Cham. https://doi.org/10.1007/978-3-319-17305-4_11
Download citation
DOI: https://doi.org/10.1007/978-3-319-17305-4_11
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-17304-7
Online ISBN: 978-3-319-17305-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)