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Epidemiology of Epstein-Barr Virus and Mechanisms of Carcinogenesis

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Tropical Hemato-Oncology

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Abstract

Epstein-Barr virus (EBV) is an ancient virus and has probably coevolved with its different hosts over the last 90–100 million years. With the ability to establish lifelong latency and intermittent reactivation after primary infection and with limited clinical symptoms in the majority of infected individuals, EBV has become ubiquitous in all human populations. The virus has been implicated in the development of a wide variety of benign and malignant diseases, although no satisfactory explanation of its role in the pathogenesis of these disorders has been still provided. In this chapter, we will uncover the immune and viral mechanisms that establish whether EBV may coexist harmoniously with the immune system as in most of individuals or whether infection could result in one of the many EBV-associated malignancies. A brief description of such diseases is also added.

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Authors and Affiliations

  1. Department of Medical Biotechnology, University of Siena, Siena, Italy

    Maria Raffaella Ambrosio & Lorenzo Leoncini

  2. Department of Pathology, University of Siena, Siena, 53100, Italy

    Lorenzo Leoncini

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  1. Maria Raffaella Ambrosio
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  2. Lorenzo Leoncini
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Correspondence to Lorenzo Leoncini .

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Editors and Affiliations

  1. Medical Oncology, Claude-Bernard-Lyon1 University, Lyon, France

    Jean-Pierre Droz

  2. Centre Hospitalier de Cayenne, Cayenne, French Guiana

    Bernard Carme

  3. Service de dermatologie, Centre hospitalier de Cayenne, Cayenne, French Guiana

    Pierre Couppié

  4. Guyane, INSERM CIC 1424, Centre d'Investigation Clinique Antilles, Centre Hospitalier de Cayenne, Cayenne, French Guiana

    Mathieu Nacher

  5. Service d’hémato-oncologie, Hôpital Saint-Louis, Paris, France

    Catherine Thiéblemont

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Ambrosio, M.R., Leoncini, L. (2015). Epidemiology of Epstein-Barr Virus and Mechanisms of Carcinogenesis. In: Droz, JP., Carme, B., Couppié, P., Nacher, M., Thiéblemont, C. (eds) Tropical Hemato-Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-18257-5_15

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