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Lung Cancer Stem Cells

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Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

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Abstract

Lung cancer remains the leading cause of cancer mortality and novel therapies are desperately needed to treat metastatic and recurrent disease. The cancer stem cell hypothesis is based on data that within each tumor there is a small sub-population of cancer stem cells that display the stem cell properties of self-renewal, pluripotency, a high proliferative capacity, and the ability to resist chemotherapy and radiation. These cancer stem cells are a likely cause of tumor resurgence after initial response to treatment and are an important therapeutic target. Distinct populations of epithelial cells in the airway and lung have been identified as the cells of origin for the major types of lung cancer: adenocarcinoma, squamous cell cancer, and small cell lung cancer. As we develop new therapies that target these cancer stem cell populations important work is underway to identify reliable cancer stem cell markers and to better understand the major pathways that fuel cancer stem cells. There is great interest in developing antibodies and small molecule inhibitors to the Wnt, Sonic Hedgehog, and Notch pathways to target cancer stem cells in lung and other malignancies, and multiple new drugs are in various stages of clinical trials. Lung cancer stem cells are a promising therapeutic target and important work remains to be done to better understand the role that lung cancer stem cells play in tumor development and recurrence.

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  1. Department of Surgery, University of California at San Francisco, San Francisco, CA, USA

    Gavitt A. Woodard & David M. Jablons

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  1. Faculty of Biol. Scs. Dept. of Mol. Gen., Tarbiat Modares University , Tehran, Iran

    Sadegh Babashah

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Woodard, G.A., Jablons, D.M. (2015). Lung Cancer Stem Cells. In: Babashah, S. (eds) Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-21030-8_8

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