Abstract
Dermatitis herpetiformis (DH) is the specific skin manifestation of celiac disease (CD) caused by the digestion of gluten in HLA-DQ2 or HLA-DQ8 individuals. DH is characterized by intensely pruritic polymorphic papulovesicular eruption on the extensor surfaces of the body. Both diseases are characterized by circulating IgA autoantibodies against tissue transglutaminase (tTG), which bind to the smooth muscle layer of the monkey esophagus causing the so-called EMA positivity. In addition, DH patients have another autoantibody population targeting the epidermal transglutaminase (eTG), the autoantigen of DH, which protein is highly homologous to tTG.
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Horváth, B., Jonkman, M.F. (2016). Dermatitis Herpetiformis. In: Jonkman, M. (eds) Autoimmune Bullous Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-23754-1_20
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DOI: https://doi.org/10.1007/978-3-319-23754-1_20
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