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Function of Antimicrobial Peptides in Lung Innate Immunity

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Antimicrobial Peptides

Part of the book series: Birkhäuser Advances in Infectious Diseases ((BAID))

Abstract

The innate immune system of the lung is a complex network of different cellular and noncellular components protecting the lung from inhaled pathogens. Antimicrobial peptides (AMP) are produced by epithelial and myeloid cells as part of this system. AMPs, such as defensins and cathelicidin, are small cationic peptides with a broad microbicidal activity against respiratory bacteria, viruses, and fungi. However, their functions go beyond antimicrobial activity and include modulation of the innate and adaptive immune response to infection as well as lung repair after injury. Thus, AMPs are involved in pathophysiological processes of many lung diseases, such as acute and chronic lung infection, chronic obstructive pulmonary disease, cystic fibrosis, and lung cancer.

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  1. Department of Internal Medicine V – Pulmonology, Allergology, Respiratory and Environmental Medicine, Saarland University, Kirrberger Str, Building 61.4, Homburg/Saar, 66421, Germany

    Frederik Seiler, Robert Bals & Christoph Beisswenger

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  1. Frederik Seiler
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  2. Robert Bals
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  3. Christoph Beisswenger
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Correspondence to Christoph Beisswenger .

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  1. Department of Dermatology, University-Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

    Jürgen Harder

  2. Department of Dermatology, University-Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

    Jens-M. Schröder

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Seiler, F., Bals, R., Beisswenger, C. (2016). Function of Antimicrobial Peptides in Lung Innate Immunity. In: Harder, J., Schröder, JM. (eds) Antimicrobial Peptides. Birkhäuser Advances in Infectious Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-24199-9_3

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