Abstract
The existence of the hemangioblast has been proposed for the first time by Sabin and Murray (Sabin 1920; Murray 1932), The first site of hematopoiesis is the yolk sac where mesodermal cells aggregate into clusters to form blood islands or hemangioblasts, consisting of an inner core of hematopoietic cells and an external layer of endothelial cells (Moore and Owen 1965; Moore and Metcalf 1970). The removal of the central cells oprecludes blood formation, but not vascular endothelium differentiation (Goss 1928).
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Ribatti, D. (2015). Human Hematopoietic Development. In: The Development of Immunologic Competence. Springer, Cham. https://doi.org/10.1007/978-3-319-24663-5_2
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