Skip to main content

Abstract

Undernutrition in critically ill patients appears to be common, being encountered both at the time of admission and developing during the ICU stay. While many definition criteria for this state are available, loss of muscle mass and strength seem to be the most relevant signs. During the ICU stay, the main reason for undernutrition is underfeeding, a frequent occurrence in ICU practice, together with bed rest. Negative energy and nitrogen balance may result in an increase in morbidity and a prolonged rehabilitation period. While nutritional support is essential for these patients, it is important not to induce the refeeding syndrome. Enteral feeding is the preferred route for providing nutritional support but is not always achievable, usually the result of prolonged feeding interruptions. The calorie target should be reached progressively using the gastrointestinal route or the parenteral route if necessary. Indirect calorimetry remains the best guide for appropriately prescribing nutritional support. Protein administration should follow current guidelines. Careful monitoring of electrolytes (mainly phosphorus, magnesium, and potassium) is mandatory. Nutritional support is of extreme importance not only to provide enough nutrients in a deficiency condition but also to prevent prolonged rehabilitation periods for survivors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Norman K, Pichard C, Lochs H, Pirlich M (2007) Prognostic impact of disease related malnutrition. Clin Nutr 27:5–15

    Article  PubMed  Google Scholar 

  2. Cederholm T, Bosaeus I, Barazzoni R et al (2015) Diagnostic criteria for malnutrition- an ESPEN consensus statement. Clin Nutr 34:335–340

    Article  CAS  PubMed  Google Scholar 

  3. Kondrup J, Rasmussen HH, Hamberg O, Stanga Z (2003) Nutritional risk screening (NRS 2002); a new method based on analysis of controlled clinical trials. Clin Nutr 22:321–336

    Article  PubMed  Google Scholar 

  4. McDermid RC, Stelfox HT, Bagshaw SM (2011) Frailty in the critically ill: a novel concept. Crit Care 15:301

    Article  PubMed  PubMed Central  Google Scholar 

  5. Fried LP, Tangen CM, Walston J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146–M156

    Article  CAS  PubMed  Google Scholar 

  6. Bector S, Vagianos K, Suh M, Duerksen DR (2015) Does the subjective global assessment predict outcome in critically ill medical patients? J Intensive Care. Epud ahead of print.

    Google Scholar 

  7. Sungurtekin H, Sungurtekin U, Oner O, Okke D (2008) Nutrition assessment in critically ill patients. Nutr Clin Pract 23:635–641

    Article  PubMed  Google Scholar 

  8. Sheean PM, Peterson SJ, Chen Y, Liu D, Lateef O, Brauschweig CA (2013) Utilizing multiple methods to classify malnutrition among elderly patients admitted to the medical and surgical intensive care units (ICU). Clin Nutr 32:752–757

    Article  PubMed  PubMed Central  Google Scholar 

  9. Roclwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitniski A (2005) A global clinical measure for fitness and frailty in elderly people. CMAJ 173:489–495

    Article  Google Scholar 

  10. The Support Principal Investigators (1995) A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). JAMA 274:1591–1598

    Article  Google Scholar 

  11. Studenski SA, Peters KW, Alley DE et al (2014) The FNIH sarcopenia project: rationale, study description, conference recommendations and final estimates. J Gerontol A Biol Sci Med Sci 69:547–558

    Article  PubMed  PubMed Central  Google Scholar 

  12. Lad UP, Satyanarayana P, Shisode-Lad S, Siri CC, Kumari NR (2013) A study of the correlation between the body mass index, the body fat percentage, the handgrip strength and the handgrip endurance in underweight, normal weight and overweight adolescents. J Clin Diagn Res 7:51–54

    PubMed  PubMed Central  Google Scholar 

  13. Fan E, Ciesla ND, Truong AD, Bhoopathi V, Zeger SL, Needham DM (2010) Inter-rater reliability of manual muscle strength testing in ICU survivors and simulated patients. Intesive Care Med 36:1038–1043

    Article  Google Scholar 

  14. Savalle M, Gillaizeau F, Maruani G et al (2012) Assessment of body cell mass at bedside in critically ill patients. Am J Physiol Endocrinol Metab 303:E389–E396

    Article  CAS  PubMed  Google Scholar 

  15. Braunschweig CA, Sheean PM, Peterson SJ et al (2014) Exploitation of diagnostic computed tomography scans to assess the impact of nutrition support on body composition changes in respiratory failure patients. JPEN J Parenter Enteral Nutr 38:880–885

    Article  PubMed  PubMed Central  Google Scholar 

  16. Biolo G (2013) Protein metabolism and requirements. In: Singer P (ed) Nutrition in intensive care: beyond physiology, vol 105, World Review of Nutrition and Dietetics. Karger, Basel, pp 12–20

    Chapter  Google Scholar 

  17. Bedavid I, Singer P, Theilla M, Hiesmayr M, et al. Nutrition day in the Intensive Care: a prevalence study. Submitted Clin Nutr

    Google Scholar 

  18. Goiburu ME, Goiburu MM, Bianco H et al (2006) The impact of malnutrition on morbidity, mortality and length of stay in trauma patients. Nutr Hosp 21:604–610

    CAS  PubMed  Google Scholar 

  19. Heyland DK, Dhaliwal R, Wang M, Day AG (2015) The prevalence of iatrogenic underfeeding on the nutritionally “at risk” critically ill patient: Results of an international, multicenter, prospective study. Clin Nutr 34:659–666

    Article  PubMed  Google Scholar 

  20. Griffiths RD, Hall JB (2010) Intensive care unit-acquired weakness. Crit Care Med 14:186

    Google Scholar 

  21. De Waele E, Spapen H, Honore PM, Mattens S, van Gorp V, Filtoer M, Huygens L (2013) Introducing a new generation indirect calorimeter for estimating energy requirements in adult intensive care patients: feasibility, practical considerations and comparison with a mathematical equation. J Crit Care 28:884

    Article  PubMed  Google Scholar 

  22. Neelemaat F. Van Bokhorst MAE, Thijs A, Seidell JC, Weijs PJM (2012) Resting energy expenditure in malnourished older patients at hospital admission and after three months after discharge; predictive equations versus measurements. Clin Nutr 31:958–966

    Article  Google Scholar 

  23. Singer P, Hiesmayr M, Biolo G, Felbinger TW, Berger MM, Goeters C, Kondrup J, Wunder C, Pichard C (2014) Pragmatic approach to nutrition in the ICU: expert opinion regarding which calorie protein target. Clin Nutr 33:246–251

    Article  PubMed  Google Scholar 

  24. Yeh DD, Fuentes E, Quraishi SA et al (2016) Adequate nutrition may get you home: effect of caloric/protein deficits on the discharge destination of critically ill surgical patients. JPEN J Parenter Enteral Nutr 40:37–44

    Article  PubMed  Google Scholar 

  25. Genton L, Cani PD, Schrenzel J (2015) Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting. Clin Nutr 34:341–349

    Article  CAS  PubMed  Google Scholar 

  26. Martindale RG, Warren M (2015) Should enteral nutrition be started in the first week of critical illness? Curr Opin Clin Nutr Metab Care 18:202–206

    Article  CAS  PubMed  Google Scholar 

  27. Hiesmayr M (2012) Nutrition risk assessment in the ICU. Curr Opin Clin Nutr Metab Care 15:174–180

    Article  CAS  PubMed  Google Scholar 

  28. Reintam Blaser A, Poeze M, Malbrain ML, Bjork M, Oudemans-van Straaten HM, Starkopf J (2013) Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: a prospective multicenter study. Intensive Care Med 39:899–909

    Article  PubMed  PubMed Central  Google Scholar 

  29. Singer P, Berger MM, van den Berghe G et al (2006) ESPEN guidelines on parenteral nutrition: intensive care. Clin Nutr 28:387–400

    Article  Google Scholar 

  30. Weimann A, Singer P (2013) Avoiding underfeeding in severely ill patients. Lancet 381:1811

    Article  PubMed  Google Scholar 

  31. Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, Van Cromphaut S, Ingels C, Meersseman P, Muller J, Vlasselaers D, Debaveye Y, Desmet L, Dubois J, Van Assche A, Vanderheyden S, Wilmer A, Van den Berghe G (2011) Early versus late parenteral nutrition in critically ill adults. N Engl J Med 365:506–517

    Article  CAS  PubMed  Google Scholar 

  32. Heidegger CP, Berger MM, Graf S, Zingg W, Darmon P, Costanza MC, Thibault R, Pichard C (2012) Optimization of energy provision with supplemental parenteral nutrition (SPN) improves the clinical outcome of critically ill patients: a randomized controlled clinical trial. Lancet 381:385–393

    Article  PubMed  Google Scholar 

  33. Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ, Heighes PT, Davies AR, O’Leary M, Solano T, Peake S (2013) Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA 309:2130–2138

    Article  CAS  PubMed  Google Scholar 

  34. Ringaitiene D, Gineityte D, Vicka V et al (2015) Impact of malnutrition on post operative delirium development after on pump coronary arterial bypass grafting. J Cardiothorac Surg 10:74

    Article  PubMed  PubMed Central  Google Scholar 

  35. Van Venrooij LM, de Vos R, Zijlstra E, Borgmeijer-Hoelen MM, van Leeuwen PA, de Mol BA (2011) The impact of low preoperative fat-free body mass on infections and length of stay after cardiac surgery: a prospective cohort study. J Thorac Cardiovasc Surg 142:1263–1269

    Article  PubMed  Google Scholar 

  36. Marvin VA, Brown D, Portlock J, Livingstone C (2009) Factors contributing to the development of hypophosphatemia when refeeding using parenteral nutrition. Pharm World Sci 30:329–335

    Article  Google Scholar 

  37. Cohen J, Kogan A, Sahar G, Lev S, Vidne B, Singer P (2004) Hypophosphatemia following open heart surgery: incidence and consequences. Eur J Cardiothorac Surg 26:306–310

    Article  PubMed  Google Scholar 

  38. Nava S, Piaggi G, De Mattia E, Carlucci A (2002) Muscle retraining in the ICU patients. Minerva Anesthosiol 68:341–345

    CAS  Google Scholar 

  39. Koukoutikos K, Tsaloglidou A, Kourkouta L (2014) Muscle atrophy in intensive care unit patients. Acta Inform Med 22:406–410

    Article  Google Scholar 

  40. DiMartini A, Cruz RJ, Dew MA, Myaskovsky L, Goodpaster B, Fox K, Him KH, Fontes P (2013) Muscle mass predicts outcomes following liver transplantation. Liver Transpl 19:1172–1180

    Article  PubMed  PubMed Central  Google Scholar 

  41. Fiaccadori E, Regolisti G, Maggiore U (2013) Specialized nutritional support interventions in critically ill patients on renal replacement therapy. Curr Opin Clin Nutr Metab Care 16:217–224

    Article  CAS  PubMed  Google Scholar 

  42. Dickerson RN, Maish GO, Croce MA, Minard G, Brown RO (2013) Influence of aging on nitrogen accretion during critical illness. JPEN J Parenteral Enter Nutr 39:282–290

    Article  Google Scholar 

  43. Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P et al (2013) Acute skeletal muscle wasting in critical illness. JAMA 310:1591–1600

    Article  CAS  PubMed  Google Scholar 

  44. Hermans G, van den Berghe G (2015) Clinical review: intensive care unit acquired weakness. Crit Care 19:274

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pierre Singer MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Singer, P., Cohen, J. (2016). Severe Undernutrition. In: Preiser, JC. (eds) The Stress Response of Critical Illness: Metabolic and Hormonal Aspects. Springer, Cham. https://doi.org/10.1007/978-3-319-27687-8_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-27687-8_15

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-27685-4

  • Online ISBN: 978-3-319-27687-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics