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Immunohistology and Molecular Studies of Cutaneous T-Cell Lymphomas and Mimics

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Applied Immunohistochemistry in the Evaluation of Skin Neoplasms

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Abstract

The skin is the second most common extranodal anatomical site for primary lymphomas. Lymphomas primarily involving the skin are a unique group of tumors that differ in many characteristics, including immunophenotype and clinical behavior, from their nodal analogs. Most of the primary cutaneous lymphomas exhibit T-cell lineage. Although histopathological examination is the clue when approaching these tumors, immunohistochemistry and molecular studies are required in most of the cases for an accurate diagnosis.

In this chapter we discuss the most commonly used antibodies for immunohistochemical evaluation of primary cutaneous T-cell lymphomas. Molecular techniques frequently utilized in this setting are also described. Each of the entities currently recognized by the World Health Organization (WHO)/European Organization for Research and Treatment of Cancer (EORTC) classification is discussed focusing on immunophenotypic and molecular findings. Differential diagnosis with inflammatory and other lymphoma mimickers is also considered for the main categories of tumors.

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Authors and Affiliations

  1. Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Carlos A. Torres-Cabala M.D. & Jonathan L. Curry M.D.

  2. Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 85, Houston, TX, 77030, USA

    Carlos A. Torres-Cabala M.D., Phyu P. Aung M.D., Ph.D. & Jonathan L. Curry M.D.

  3. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Roberto N. Miranda M.D.

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    Jose A. Plaza

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    Victor G. Prieto

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Torres-Cabala, C.A., Aung, P.P., Miranda, R.N., Curry, J.L. (2016). Immunohistology and Molecular Studies of Cutaneous T-Cell Lymphomas and Mimics. In: Plaza, J., Prieto, V. (eds) Applied Immunohistochemistry in the Evaluation of Skin Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-30590-5_10

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