Abstract
As of 2012, 29.1 million Americans are living with diabetes [1], creating a significant healthcare concern for the United States. Diabetes is a disease highly driven by inflammation and reactive oxygen species (ROS). Therefore, agents that affect secondary inflammation as a result of oxidative stress like metalloporphyrins are a desirable approach to alleviate the inflammation associated with disease. Here, we will discuss the role ROS play in the immunopathology of diabetes, the work that has elucidated the efficacy of metalloporphyrins in the disease, and their future utility in the clinic.
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Coudriet, G.M., Previte, D.M., Piganelli, J.D. (2016). Using Metalloporphyrins to Preserve β Cell Mass and Inhibit Immune Responses in Diabetes. In: Batinić-Haberle, I., Rebouças, J., Spasojević, I. (eds) Redox-Active Therapeutics. Oxidative Stress in Applied Basic Research and Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-30705-3_29
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