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Depression and Markers of Arteriosclerosis: Cross-Sectional Analyses of the Baseline Examination of the BiDirect Cohort Study

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Cardiovascular Diseases and Depression

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Abstract

The prospective BiDirect study was set up to uncover the potential bidirectional links between depression and arteriosclerosis, with a focus on markers of early and subclinical arteriosclerosis.

The BiDirect cohort is composed of three different samples: a subsample of patients with clinically manifest depression, a cohort of patients after an acute cardiovascular event, and a reference group that was drawn from the general population. All study participants underwent interviews, anthropometric measurements, and measurements of blood pressure, ankle-brachial index (ABI), pulse wave velocity (PWV), augmentation index, body impedance, and carotid intima-media thickness (IMT). Composite, unweighted scores were created as summary measures to assess the burden of subclinical arteriosclerosis in the different subsamples. The BiDirect baseline examination lasted from May 2010 to June 2013. Cross-sectional analyses of the baseline examination revealed significantly increased measures for body and fat mass, but lower levels of blood pressure in the depressive cohort. Single indicators of subclinical arteriosclerosis (ankle-brachial index (ABI), pulse wave velocity (PWV), intima-media thickness (IMT), and carotid plaque) as well as an unweighted composite score of these markers showed no differences between the depression and the reference cohort at baseline. However, when the presence of adverse lifestyle factors, such as smoking and overweight, was additionally taken into consideration, the depressive cohort showed a raised propensity to arteriosclerosis, especially among those younger than 50 years. Expectedly, the cohort with clinically manifest cardiovascular disease showed consistently the highest values and scores of arteriosclerosis.

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References

  • Aboyans V et al (2007) Intrinsic contribution of gender and ethnicity to normal ankle-brachial index values: the Multi-Ethnic Study of Atherosclerosis (MESA). J Vasc Surg 45:319–327

    Article  PubMed  Google Scholar 

  • Aboyans V et al (2012) Measurement and interpretation of the ankle-brachial index a scientific statement from the American Heart Association. Circulation 126:2890–2909

    Article  PubMed  Google Scholar 

  • Barth J, Schumacher M, Herrmann-Lingen C (2004) Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. Psychosom Med 66:802–813

    Article  PubMed  Google Scholar 

  • Baulmann J et al (2010) Arterial stiffness and pulse wave analysis. Dtsch Med Wochenschr 135(Suppl 1):S4–S14

    Article  PubMed  Google Scholar 

  • Busch MA, Maske UE, Ryl L, Schlack R, Hapke U (2013) Prävalenz von depressiver Symptomatik und diagnostizierter Depression bei Erwachsenen in Deutschland: Ergebnisse der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1). Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 56:733–739

    Article  CAS  Google Scholar 

  • Clement DL et al, with Mancia G et al, ESH Scientific Council, Redon J et al, ESC Committee for Practice Guidelines (CPG), Zamorano JL et al, Document Reviewers (2013) 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 34: 2159–2219

    Google Scholar 

  • Davidson K, Jonas BS, Dixon KE, Markovitz JH (2000) Do depression symptoms predict early hypertension incidence in young adults in the cardia study? Arch Intern Med 160:1495–1500

    Article  CAS  PubMed  Google Scholar 

  • De Jonge P et al (2010) Psychophysiological biomarkers explaining the association between depression and prognosis in coronary artery patients: a critical review of the literature. Neurosci Biobehav Rev 35:84–90

    Article  PubMed  Google Scholar 

  • Delaney JAC et al (2010) Baseline depressive symptoms are not associated with clinically important levels of incident hypertension during two years of follow-up the multi-ethnic study of atherosclerosis. Hypertension 55:408–414

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Deutscher Herzbericht (2013) Deutsche Herzstiftung (Hg.), Frankfurt

    Google Scholar 

  • Dietz LJ, Matthews KA (2011) Depressive symptoms and subclinical markers of cardiovascular disease in adolescents. J Adolesc Health Off Publ Soc Adolesc Med 48:579–584

    Article  Google Scholar 

  • Elovainio M et al (2005) Depressive symptoms and carotid artery intima-media thickness in young adults: the Cardiovascular Risk in Young Finns Study. Psychosom Med 2005(67):561–567

    Article  Google Scholar 

  • Gehi A et al (2010) Depression and platelet activation in outpatients with stable coronary heart disease: findings from the Heart and Soul Study. Psychiatry Res 175:200–204

    Article  CAS  PubMed  Google Scholar 

  • Grippo AJ, Johnson AK (2009) Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models: review. Stress Int J Biol Stress 12:1–21

    Article  CAS  Google Scholar 

  • Hildrum B, Romild U, Holmen J (2011) Anxiety and depression lowers blood pressure: 22-year follow-up of the population based HUNT study, Norway. BMC Public Health 11:601

    Article  PubMed  PubMed Central  Google Scholar 

  • Huxley RR et al (2014) A comparative analysis of risk factors for stroke in blacks and whites: the atherosclerosis risk in communities study. Ethn Health 19:601–616

    Article  PubMed  Google Scholar 

  • Izzo JL Jr, Mitchell GF (2007) Aging and arterial structure-function relations. Adv Cardiol 44:19–34

    Article  PubMed  Google Scholar 

  • Laurent S et al, on behalf of the European Network for Non-invasive Investigation of Large Arteries (2006) Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur. Heart J 27:2588–2605

    Google Scholar 

  • Lean MEJ, Han TS, Morrison CE (1995) Waist circumference as a measure for indicating need for weight management. BMJ 311:158–161

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Libby P (2012) Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol 32:2045–2051

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Libby P, Ridker PM, Hansson GK (2011) Progress and challenges in translating the biology of atherosclerosis. Nature 473:317–325

    Article  CAS  PubMed  Google Scholar 

  • Lichtman JH et al (2014) Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations a scientific statement from the American Heart Association. Circulation 129:1350–1369

    Article  PubMed  Google Scholar 

  • Liu P, Ma F, Lou H, Liu Y (2013) The utility of fat mass index vs. body mass index and percentage of body fat in the screening of metabolic syndrome. BMC Public Health 13:629

    Article  PubMed  PubMed Central  Google Scholar 

  • Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M (2007) Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 115:459–467

    Article  PubMed  Google Scholar 

  • Luppino FS et al (2010) Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry 67:220–229

    Article  PubMed  Google Scholar 

  • Mathers CD, Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3:e442

    Article  PubMed  PubMed Central  Google Scholar 

  • Meijer A et al (2011) Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research. Gen Hosp Psychiatry 33:203–216

    Article  PubMed  Google Scholar 

  • Meng L, Chen D, Yang Y, Zheng Y, Hui R (2012) Depression increases the risk of hypertension incidence: a meta-analysis of prospective cohort studies. J Hypertens 30:842–851

    Article  CAS  PubMed  Google Scholar 

  • Nabi H et al (2011) Trajectories of depressive episodes and hypertension over 24 years the Whitehall II prospective cohort study. Hypertension 57:710–716

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Newson RS et al (2010) Atherosclerosis and incident depression in late life. Arch Gen Psychiatry 67:1144–1151

    Article  PubMed  Google Scholar 

  • Nicholson A, Kuper H, Hemingway H (2006) Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. Eur Heart J 27:2763–2774

    Article  PubMed  Google Scholar 

  • Niranjan A, Corujo A, Ziegelstein RC, Nwulia E (2012) Depression and heart disease in US adults. Gen Hosp Psychiatry 34:254–261

    Article  PubMed  Google Scholar 

  • Ohira T et al (2012) Associations of anger, anxiety, and depressive symptoms with carotid arterial wall thickness: the multi-ethnic study of atherosclerosis. Psychosom Med 74:517–525

    Article  PubMed  PubMed Central  Google Scholar 

  • Ong K-T et al (2011) Aortic stiffness is reduced beyond blood pressure lowering by short-term and long-term antihypertensive treatment: a meta-analysis of individual data in 294 patients. J Hypertens 2011(29):1034–1042

    Article  Google Scholar 

  • Rice SC, Zonderman AB, Metter EJ, Najjar SS, Waldstein SR (2009) Absence of relation between depressive symptoms and carotid intimal medial thickness in the Baltimore Longitudinal Study of Aging. Psychosom Med 71:70–76

    Article  PubMed  Google Scholar 

  • Rugulies R (2002) Depression as a predictor for coronary heart disease a review and meta-analysis. Am J Prev Med 23:51–61

    Article  PubMed  Google Scholar 

  • Sass H, Wittchen H-U, Zaudig M (1996) Diagnostic and statistical manual psychischer Störungen - DSM-IV. Deutsche Bearbeitung u. Einleitung von Sass H, Wittchen H-U, Zaudig M Göttingen: Hogrefe

    Google Scholar 

  • Schutz Y, Kyle UG, Pichard C (2002) Fat-free mass index and fat mass index percentiles in Caucasians aged 18–98 y. Int J Obes 26:953–960

    Article  CAS  Google Scholar 

  • Seldenrijk A et al (2011) Depression, anxiety, and arterial stiffness. Biol Psychiatry 69:795–803

    Article  PubMed  Google Scholar 

  • Smith FB, Lee AJ, Price JF, van Wijk MCW, Fowkes FGR (2003) Changes in ankle brachial index in symptomatic and asymptomatic subjects in the general population. J Vasc Surg 38:1323–1330

    Article  PubMed  Google Scholar 

  • Stewart JC, Janicki DL, Muldoon MF, Sutton-Tyrrell K, Kamarck TW (2007) Negative emotions and 3-year progression of subclinical atherosclerosis. Arch Gen Psychiatry 64:225–233

    Article  PubMed  Google Scholar 

  • Teismann H et al (2014) Establishing the bidirectional relationship between depression and subclinical arteriosclerosis-rationale, design, and characteristics of the BiDirect study. BMC Psychiatry 14:174

    Article  PubMed  PubMed Central  Google Scholar 

  • Tiemeier H et al (2004) Relationship between atherosclerosis and late-life depression: the Rotterdam study. Arch Gen Psychiatry 61:369–376

    Article  PubMed  Google Scholar 

  • Tikhonoff V et al (2014) Symptoms of anxiety and depression across adulthood and blood pressure in late middle age: the 1946 British birth cohort. J Hypertens 32:1590–1598

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Van Bortel LM et al (2012) Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens 30:445–448

    Article  PubMed  Google Scholar 

  • Van den Oord SCH et al (2013) Carotid intima-media thickness for cardiovascular risk assessment: systematic review and meta-analysis. Atherosclerosis 228:1–11

    Article  PubMed  Google Scholar 

  • Van der Kooy K et al (2007) Depression and the risk for cardiovascular diseases: systematic review and meta-analysis. Int J Geriatr Psychiatry 22:613–626

    Article  PubMed  Google Scholar 

  • Wang K-L et al (2010) Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities a community-based study. Hypertension 55:799–805

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • WHO | 10 facts on obesity. At: http://www.who.int/features/factfiles/obesity/facts/en/

  • Wulsin LR, Singal BM (2003) Do depressive symptoms increase the risk for the onset of coronary disease? A systematic quantitative review. Psychosom Med 65:201–210

    Article  PubMed  Google Scholar 

  • Wulsin LR et al (2005) Depressive symptoms, coronary heart disease, and overall mortality in the Framingham Heart study. Psychosom Med 67:697–702

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Epidemiology and Social Medicine, Medical Faculty, Westfälische Wilhelms University, Albert-Schweitzer-Campus 1 D3, 48149, Münster, Germany

    Maren Nagel MD & Hans-Werner Hense MD

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  1. Maren Nagel MD
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  2. Hans-Werner Hense MD
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Correspondence to Hans-Werner Hense MD .

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Editors and Affiliations

  1. Discipline of Psychiatry, School of Medicine , University of Adelaide, Adelaide, Australia

    Bernhard T. Baune

  2. The Freemason's Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, University of Adelaide, Adelaide, SA, Australia

    Phillip J. Tully

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Nagel, M., Hense, HW. (2016). Depression and Markers of Arteriosclerosis: Cross-Sectional Analyses of the Baseline Examination of the BiDirect Cohort Study. In: Baune, B., Tully, P. (eds) Cardiovascular Diseases and Depression. Springer, Cham. https://doi.org/10.1007/978-3-319-32480-7_13

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  • DOI: https://doi.org/10.1007/978-3-319-32480-7_13

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