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The Risk Relationship Between Depression and CVD During Ageing

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Cardiovascular Diseases and Depression

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Abstract

Late-life depression is one of the most common psychiatric disorders in older adults with a prevalence of 2–10 % in people aged 65 and above. Depression in old age has been associated with functional impairment and many adverse health effects. While there are overlapping symptoms and outcomes of depression throughout the life span, there is evidence for distinct medical, clinical, cognitive, neuroimaging, neuropathological, inflammatory and genetic features for geriatric depression in comparison with depression in young age (see Naismith et al. 2012). Older people with major depression have an increased risk of developing dementia, in particular Alzheimer’s disease and vascular dementia. There is strong evidence for cardiovascular risk factors being an underlying link between depression and dementia. A recent systematic review and meta-analysis showed that late-life depression is associated with a significant risk of all-cause dementia, Alzheimer’s disease and vascular dementia. However, the risk to develop vascular dementia was significantly higher than for Alzheimer’s disease (Diniz et al. 2013). Studies suggest that recurrent depression with an onset in midlife may reflect a long-term process of cerebrovascular changes that may be aetiologically related to the development of vascular dementia (Barnes et al. 2012).

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Authors and Affiliations

  1. Centre for Healthy Brain Ageing, UNSW Medicine, Kensington, NSW, Australia

    Simone Reppermund & Ruby S. M. Tsang

  2. Department of Developmental Disability Neuropsychiatry, UNSW Medicine, Kensington, NSW, Australia

    Simone Reppermund

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  1. Simone Reppermund
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Correspondence to Simone Reppermund .

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  1. Discipline of Psychiatry, School of Medicine , University of Adelaide, Adelaide, Australia

    Bernhard T. Baune

  2. The Freemason's Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, University of Adelaide, Adelaide, SA, Australia

    Phillip J. Tully

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Reppermund, S., Tsang, R.S.M. (2016). The Risk Relationship Between Depression and CVD During Ageing. In: Baune, B., Tully, P. (eds) Cardiovascular Diseases and Depression. Springer, Cham. https://doi.org/10.1007/978-3-319-32480-7_3

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