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Chemistry, Pharmacodynamics, and Pharmacokinetics of NSAIDs

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NSAIDs and Aspirin

Abstract

Numerous chemically different entities are clustered under the label of nonsteroidal anti-inflammatory drugs (NSAIDs). They share the ability to inhibit prostanoid synthesis by blocking the activity of the cyclooxygenase enzymes and, as a consequence, to exert anti-inflammatory, analgesic, and antipyretic effects. On the other hand, by hindering the housekeeping roles of prostaglandins, they also deteriorate the gastrointestinal mucosal barrier and the renal and endothelial hemodynamic regulation. The present chapter compiles available pharmacokinetic and pharmacodynamic data that may help to understand the different therapeutic profiles reported for particular agents.

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Authors and Affiliations

  1. Department of Pharmacology and CIBERehd, Faculty of Medicine, University of Valencia, Av. Blasco Ibáñez, 17, 46010, Valencia, Spain

    Sara Calatayud Ph.D. & Juan Vicente Esplugues M.D., Ph.D.

Authors
  1. Sara Calatayud Ph.D.
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  2. Juan Vicente Esplugues M.D., Ph.D.
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Corresponding author

Correspondence to Sara Calatayud Ph.D. .

Editor information

Editors and Affiliations

  1. IIS Aragón, CIBER Enfermedades Hepáicas y Digestivas (CIBERehd), Universidad de Zaragoza, Zaragoza, Spain

    Angel Lanas

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© 2016 Springer International Publishing Switzerland

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Calatayud, S., Esplugues, J.V. (2016). Chemistry, Pharmacodynamics, and Pharmacokinetics of NSAIDs. In: Lanas, A. (eds) NSAIDs and Aspirin. Springer, Cham. https://doi.org/10.1007/978-3-319-33889-7_1

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  • DOI: https://doi.org/10.1007/978-3-319-33889-7_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33887-3

  • Online ISBN: 978-3-319-33889-7

  • eBook Packages: MedicineMedicine (R0)

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