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Dermatologic Manifestations in Renal Failure

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Dermatology in Public Health Environments

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Abstract

Chronic renal failure (CRF) is a major public health problem worldwide. Patients living with CRF are considered to follow a chronic inflammatory state due to multiple factors. From a dermatologic point of view, there is a high frequency of dermatoses associated with this condition. They can be divided into specific and nonspecific, the latter having the highest prevalence, but all of them show a significant impact on the quality of life of affected patients. Xerosis, bruising, and itching are ubiquitous in this population and are considered multifactorial. Among them, xerosis, pale skin and itching are the most prevalent ones. On the other hand, specific dermatoses are classified as acquired perforating disorders, bullous dermatoses, calcification disorders, nephrogenic systemic fibrosis, specific nail changes, and uremic frost. Most skin disorders are benign and do not affect the course of CRF. On several occasions skin disorders can predict the initiation of a renal replacement plan, or may be precipitated by it.

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Author information

Authors and Affiliations

  1. Assistant Professor of Dermatology, Hospital de Clínicas “Dr. Manuel Quintela”, de Montevideo, Uruguay

    Lídice Dufrechou Varela

  2. Adjunct Professor of Dermatology, Hospital de Clìnicas “Dr. Manuel Quintela”, de Montevideo, Uruguay

    Alejandra Larre Borges

  3. Hospital de Clínicas “Dr. Manuel Quintela”, Montevideo, Uruguay

    Andrea Nicola Centanni

Authors
  1. Lídice Dufrechou Varela
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  2. Alejandra Larre Borges
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  3. Andrea Nicola Centanni
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Corresponding author

Correspondence to Lídice Dufrechou Varela .

Editor information

Editors and Affiliations

  1. Dermatology Service of Clinical, Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

    Renan Rangel Bonamigo

  2. Health Secretary of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Sergio Ivan Torres Dornelles

Glossary

Dyschromia 

Alteration of the color of the skin.

Gynecomastia 

Enlargement of the breast in the males, caused by an excess of estrogens.

Macroglossia 

Excessively large tongue.

Microangiopathy 

Pathologic processes of the microvessels.

Pruritogenic substances 

Substances capable of causing pruritus (itching).

Raynaud’s phenomenon 

Abrupt onset of digital paleness followed by cyanosis and erythema in response to cold.

Teratogenic effect 

Capacity of some substances of generate physical defects in the developing embryo.

Uroporphyrins 

Porphyrins produced by oxidation of uroporphyrinogen, which can be excreted in excess in the urine in the context of porphyrias.

Xerostomia 

Decreased salivary flow (dry mouth).

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Varela, L.D., Borges, A.L., Centanni, A.N. (2018). Dermatologic Manifestations in Renal Failure. In: Bonamigo, R., Dornelles, S. (eds) Dermatology in Public Health Environments. Springer, Cham. https://doi.org/10.1007/978-3-319-33919-1_44

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  • DOI: https://doi.org/10.1007/978-3-319-33919-1_44

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33917-7

  • Online ISBN: 978-3-319-33919-1

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