Abstract
This chapter explores the pathologic features of benign and malignant lesions of the pancreas. As pathologic classifications evolve, particularly for cystic lesions and neuroendocrine tumors, it is important for physicians who treat patients with pancreatic neoplasms to fully evaluate these pathologic classifications.
Ashley M. Cunningham, MD and Patrick S. Rush, DO have contributed equally.
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References
Abraham S, Klimstra D, Wilentz R, Yeo C, Conlon K, Brennan M, Cameron J, Wu T, Hruban R (2002) Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost alsways harbor beta-catenin mutations. Am J Pathol 160(4):1361–1369
Adsay NV, Fukushima N, Furukawa T, Hruban R, Klimstra D, Kloppel G, Offerhaus G et al (2010) Intraductal neoplasms of the pancreas. World Health Organization Classification of Tumours of the Digestive System. IARC Press, Lyon, France, pp 304–313
American Cancer Society (ACS) Pancreatic cancer. American Cancer Society. Available at http://www.cancer.org/cancer/pancreaticcancer/detailedguide/pancreatic-cancer-key-statistics. Accessed: 26 Aug 2015
Brugge WR (2015) Diagnosis and management of cystic lesions of the pancreas. J Gastrointest Oncol 6(4):375–388
Collisson EA, Sadanandam A, Olson P, Gibb WJ, Truitt M, Cooc J, Weinkle J et al (2011) Subtypes of Pancreatic Ductal Adenocarcinoma and their differing responses to therapy. Nat Med 17(4):500–503
Decker GA, Batheja MJ, Collins JM et al (2010) Risk factors for pancreatic adenocarcinoma and prospects for screening. Gastroenterol Hepatol 6(4):246–254
Distler M, Aust D, Weitz J, Pilarsky C, and Grutzmann R (2014) Precursor lesions for sporadic pancreatic cancer: PanIn, IPMN, and MCN. BioMed Res Int. Published online 24 March 2014
Hruban RH, Fukushima N (2007) Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs. Mod Pathol 20:S61–S70
Hruban Rh, Klöppel G, Boffetta P, Maitra A, Hiraoka N, Offerhaus GJA, Iacobuzio-Donahue C et al (2010) Ductal adenocarcinoma of the pancreas. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (eds) WHO classification of tumours of the digestive system. WHO Press, Geneva, pp 281–291
Hruban RH, Maitra A, Kern SE, Goggins M (2007) Precursors to pancreatic cancer. Gastroenterol Clin North Am 36(4):831-vi
Hruban RH, Molina JM, Reddy MN et al (1987) A neoplasm with pancreatic and hepatocellular differentiation presenting with subcutaneous fat necrosis. Am J Clin Pathol 88:639–645
Hruban RH, Pitman MB, Limstra DS (eds) (2007) Tumors of the pancreas. Armed Forces Institute of Pathology, Washington, DC
Kardon DE, Thompson LDR, Przygodzki RM, Heffess CS (2001) Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases. Mod Pathol 14(5):443–451
Kim T, Fernandez-del Castillo C (2015) Diagnosis and management of pancreatic cystic neoplasms. Hematol Oncol Clinic N Am 29:655–674
Klimstra D, Adsay NV (2009) Tumors of the pancreas and ampulla of vater. In: Odze R, Goldblum J (eds) Surgical pathology of the GI tract, liver, biliary tract and pancreas. Saunders, Philadelphia, pp 909–960
Klimstra D, Hruban R, Kloppel G, Morohoshi T, Ohike N (2010) Acinar cell neoplasms of the pancreas. World Health Organization Classification of Tumours of the Digestive System. IARC Press, Lyon, France, pp 314–318
Kloppel G, Hruban R, Klimstra D, Maitra A, Morohoshi T, Notohara K, Shimizu M, Terris B (2010) Solid-pseudopapillary neoplasm of the pancreas. World Health Organization Classification of Tumours of the Digestive System. IARC Press, Lyon, pp 327–330
La Rosa S, Sessa F, Capella C (2015) Acinar cell carcinoma of the pancreas: overview of clinicopathologic features and insights into the molecular pathology. Front Med 2(41):1–13
Lester SC (2010) Gastrointestinal specimens (including hepatobiliary and pancreatic specimens. In: Manual of surgical pathology, 3rd edn. Elsevier, Philadelphia, pp 323–383
Lowery M, Klimstra D, Shia J, Yu K, Allen P, Brennan M, O’Reilly E (2011) Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy. Oncologist: Gastrointest Cancer 16:1714–1720
Milan SA, Yeo CJ (2012) Neuroendocrine tumors of the Pancreas. Curr Opin Oncol 24(1):46–55
Morohoshi T, Hruban R, Klimstra D, Ohike N, Terris B (2010) Pancreatoblastoma. World Health Organization Classification of Tumours of the Digestive System. IARC Press, Lyon, pp 319–321
Norris AL, Roberts NJ, Jones S, Wheelan SJ, Papadopoulos N, Vogelstein B, Kinzler KW et al (2015) Familial and sporadic pancreatic pancreatic cancer share the same molecular pathogenesis. Fam Cancer 14:95–103
Omiyale A (2015) Clinicopathological review of pancreatoblastoma in adults. Gland Surgery 4(4):322–328
Rindi G, Arnold R, Bosman FT, Capella C, Klimstra DS, Kloppel G, Komminoth P, Solica E (2010) Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In: Bosman T, Carneiro F, Hruban R, Theise N (eds) WHO classification of tumors of the digestive system, 4th edn. International Agency for Research on Cancer (LARC), Lyon, pp 13–14
Rosai J (2011) Pancreas and ampullary region. Rosai and Ackerman’s surgical pathology 10th edn. Mosby, Edinburgh, pp 1006–1055
Seton-Rogers S (2015) Pancreatic cancer: a matter of timing. Nat Rev Cancer. doi:10.1038/nrc3948
Surveillance, Epidemiology, and End Results (SEER) Program (2015) SEER Stat Fact Sheets: Pancreas Cancer. Available at http://seer.cancer.gov/statfacts/html/pancreas.html. Accessed: 26 Aug 2015
Thompson LDR, Heffess CS (2010) Pancreas. In: Mills SE (ed) Sternberg’s diagnostic surgical pathology, 5th edn. Lippincott Williams & Wilkins, Baltimore, pp 1432–1491
Turner B, Brugge W (2010) Diagnostic and therapeutic endoscopic approaches to intraductal papillary mucinous neoplasm. World J Gastrointest Surg 2(10):337–341
Wahrenbrock M, Borsig L, Le D, Varki N, Varki A (2003) Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas. J Clin Invest 112(6):853–862
Whitecomb DC, Shelton C, Brand RE (2015) Genetics and genetic testing in pancreatic cancer. Gastroenterology. doi:10.1053/j.gastro.2015.07.057
Zamboni G, Fukushima N, Hruban RH, Kloppel G (2010). Mucinous cystic neoplasms of the pancreas. World Health Organization Classification of Tumours of the Digestive System. IARC Press, Lyon, pp 300–303
Zhou C, Zhang J, Zheng Y, Zhi Z (2012) Pancreatic neuroendocrine tumors: a comprehensive review. Int J Cancer 131(5):1013–1022
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Cunningham, A.M., Rush, P.S., Matkowskyj, K.A. (2016). Pathologic Features of Primary Pancreatic Malignancies. In: Bentrem, D., Benson, A. (eds) Gastrointestinal Malignancies. Cancer Treatment and Research. Springer, Cham. https://doi.org/10.1007/978-3-319-34244-3_5
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DOI: https://doi.org/10.1007/978-3-319-34244-3_5
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