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Overview of Oncology Biomarkers

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Pharmacokinetics in Drug Development

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Abstract

Biomarkers, whether predictive or prognostic of disease, are an essential element of every modern targeted oncology drug development program. Because they can provide information about the mechanism of drug action, carcinogenesis, and patient characteristics specific to both disease and treatment, they offer the opportunity to individualize therapies and to realize potential of personalized medicine. This chapter provides an introduction to biomarkers, their definition and collection, with emphasis on the utility in colon, breast and lung cancers.

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Authors and Affiliations

  1. Department of Gastroenterological Chemotherapy, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan

    Stefan J. Scherer

  2. USC Norris Cancer Center, 1441 Eastlake Ave Suite 3456, Los Angeles, CA, 90089, USA

    Heinz-Josef Lenz

  3. VP Global Head Correlative Science, Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, 07936-1080, USA

    Mitsukuni Suenaga

Authors
  1. Mitsukuni Suenaga
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  2. Heinz-Josef Lenz
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  3. Stefan J. Scherer
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Corresponding author

Correspondence to Stefan J. Scherer .

Editor information

Editors and Affiliations

  1. Pharmacokinetics/Modeling/Simulation 2N.184 Astellas, Global Clinical Pharmacology and Exploratory Development, Northbrook, Illinois, USA

    Peter L. Bonate

  2. Oncology Clinical Pharmacology Novartis, East Hanover, New Jersey, USA

    Danny R. Howard

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Suenaga, M., Lenz, HJ., Scherer, S.J. (2016). Overview of Oncology Biomarkers. In: Bonate, P., Howard, D. (eds) Pharmacokinetics in Drug Development. Springer, Cham. https://doi.org/10.1007/978-3-319-39053-6_2

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