Abstract
Cytopathologic diagnosis of bone and soft tissue tumors is unquestionably challenging. Some of the tumors are rare, tumors with markedly disparate behavior may resemble each other to a striking degree (such as a schwannoma with degenerative atypia and malignant peripheral nerve sheath tumor), and the complex categorization of these tumors continues to evolve. Fortunately, cytopathologic examination does not proceed in a vacuum: the patient’s clinical history and imaging findings can narrow the differential significantly. Moreover, immunocytochemistry and molecular genetic testing can be performed on cytologic specimens and enable a more specific diagnosis. Molecular genetic based tests such as fluorescent in situ hybridization, PCR and high throughput sequencing are increasingly deployed in bone and soft tissue tumor diagnosis, and cytology specimens are often ideal for such tests.
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Samedi, V.G., Bocklage, T. (2016). Bone and Soft Tissue Cytology. In: Pitfalls in Diagnostic Cytopathology With Key Differentiating Cytologic Features. Essentials in Cytopathology, vol 27. Springer, Cham. https://doi.org/10.1007/978-3-319-39809-9_12
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DOI: https://doi.org/10.1007/978-3-319-39809-9_12
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