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Preclincial Models for Studying Breast Cancer

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The Pathobiology of Breast Cancer

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Abstract

Although the use of cell lines in tissue culture is a widely accepted method for testing drugs [1, 2], it has been observed that not all the data obtained in the in vitro system are translational to the human situation. Therefore, the study in animals is extremely important in all the preclinical studies. As an example the data presented in this chapter summarizes data obtained using xenotransplantation model of breast cancer in which the final malignant phenotype of tumorigenesis has been tested. Tumorigenesis in heterologous hhots is a reliable marker to determine that the transformation of human breast epithelial cells (HBEC) treated in vitro with different carcinogenic agents are really transforming one. For this purpose we will describe different examples on how to use the model of xenotransplantation to verify the malignancy of cell lines, or for detecting the transforming abilities, of oncogenes, chemical carcinogens or hormones. We will also describe the metastatic model most often used in breast cancer research and finally we will describe the development of a unique preclinical model for the triple negative breast cancer.

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  1. Fox Chase Cancer Center, Philadelphia, PA, USA

    Jose Russo

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Russo, J. (2016). Preclincial Models for Studying Breast Cancer. In: The Pathobiology of Breast Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-40815-6_9

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