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Current Issues in Clinical and Translational Research in the Hearing Sciences, Audiology, and Otolaryngology

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Translational Research in Audiology, Neurotology, and the Hearing Sciences

Part of the book series: Springer Handbook of Auditory Research ((SHAR,volume 58))

Abstract

Translational research is often described as “bench to bedside” because it builds on basic science findings to “translate” discoveries into potential interventions or therapeutics that can be tested in clinical trials and adopted into healthcare practice. This introductory chapter offers working definitions of the various phases of research spanning from basic research to clinical testing and ultimately to the implementation of these endeavors into evidence-based patient care. There are multiple challenges in moving from basic science to clinical trials and from clinical research into routine application in healthcare delivery. There are also clearly diverging interests of academics (creation of knowledge, education of the future workforce) and industry (meeting market needs and protecting exclusivity to generate revenue and increase shareholder value). However, academia and industry share the common goal of finding cures for patients in need. Whether patient care is advanced through industry-funded research within an academic laboratory or industry licensing of an academic patent is not important from the patient’s perspective. What will benefit patients the most in the long run is the translation of novel therapies into clinical testing with subsequent translation of the most effective therapies into patient care, with the long-term goal of improving public health outcomes.

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Notes

  1. 1.

    1Colleen Le Prell was the principal investigator on the contract between Sound Pharmaceuticals, Inc. and the University of Florida.

  2. 2.

    Colleen Le Prell is an inventor on these patents; see references for detailed information.

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Acknowledgments

Translational research must be approached as team science, with scientists, clinicians, physicians, statisticians, experts in the regulatory rules and IND preparation, and, of course, a clinical trial manager all contributing important pieces. I am grateful to the many friends and colleagues who have partnered with me on the studies described in this chapter, including Patrick Antonelli, Edward Lobarinas, Christopher Spankovich, Scott Griffiths, and Leigh Anne Marshall at the University of Florida; Josef Miller, Glenn Green, Bill Reisdorph, and Kenneth Guire at the University of Michigan; Kathleen Campbell at Southern Illinois University; Eric Lynch and Jonathon Kil at Sound Pharmaceuticals, Inc., and Matt Klein and Erin Johnson at Edison Pharmaceuticals, Inc. I appreciate helpful comments on an earlier version of this manuscript from Edward Lobarinas, Art Popper, and Jianxin Bao.

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  1. Callier Center for Communication Disorders, University of Texas at Dallas, 1966 Inwood Road, Dallas, Texas, 75235, USA

    Colleen G. Le Prell

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  1. Colleen G. Le Prell
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Correspondence to Colleen G. Le Prell .

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Editors and Affiliations

  1. Callier Center for Communication Disorders, University of Texas at Dallas, Dallas, Texas, USA

    Colleen G. Le Prell

  2. Callier Center for Communication Disorders, University of Texas at Dallas, Dallas, Texas, USA

    Edward Lobarinas

  3. Department of Biology, University of Maryland, College Park, Maryland, USA

    Arthur N. Popper

  4. Marine Biological Laboratory, Woods Hole, Massachusetts, USA

    Richard R. Fay

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Colleen Le Prell has received contract funding from industry sources including Sound Pharmaceuticals, Inc., Edison Pharmaceuticals, Inc., Hearing Health Sciences, Inc., and MaxSound, Inc. She is a co-inventor on patents assigned to the University of Michigan and the University of Florida.

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Le Prell, C.G. (2016). Current Issues in Clinical and Translational Research in the Hearing Sciences, Audiology, and Otolaryngology. In: Le Prell, C., Lobarinas, E., Popper, A., Fay, R. (eds) Translational Research in Audiology, Neurotology, and the Hearing Sciences. Springer Handbook of Auditory Research, vol 58. Springer, Cham. https://doi.org/10.1007/978-3-319-40848-4_2

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