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Delayed Puberty: Impact on Female Fertility

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Frontiers in Gynecological Endocrinology

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Abstract

Puberty is the period of life that leads to adulthood through complicated and sometimes painful physiological and psychological changes. The hypothalamic-pituitary-gonadal axis undergoes an active phase during foetal and neonatal development and then enters a resting phase that lasts for the rest of childhood until puberty. Puberty begins with an activation of the hypothalamic-pituitary-gonadal system. It occurs today earlier than a century and even earlier than half a century or 20 years ago. Delayed puberty may have a dramatic impact on the mental and social development of an adolescent. In the literature, different definitions for “delayed puberty” can be found and there are no guidelines indicating when in the absence of pubertal signs an investigation should be started. Usually, in girls, a first evaluation should be done not later than at the age of 13. However, the initiation of a first evaluation has to be earlier in some cases: it depends on the psychosocial pressure exerted on a child by her personal delay when it is compared to the pubertal development of the pair group of schoolmates and friends. One thing that quite often worries the patient and her parents the most is the impact of delayed puberty might have on later fertility.

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References

  1. Marshall WA, Tanner JM (1970) Variations in the pattern of pubertal changes in boys. Arch Dis Child 45:13–23

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Lee PA (1980) Normal ages of pubertal events among American males and females. J Adolesc Health Care 1:26–29

    Article  CAS  PubMed  Google Scholar 

  3. Speroff, Fritz (2005) Clinical gynecological endocrinology and infertility, 7th edn, LipinCott, Williams & Wilkins, Philadelphia

    Google Scholar 

  4. Largo RH, Prader A (1983) Pubertal development in Swiss girls. Helv Paediatr Acta 38(3):229–243

    CAS  PubMed  Google Scholar 

  5. Tanner JM (1962) Growth at adolescence. Charles C Thomas, Springfield

    Google Scholar 

  6. Stavrou I, Zois C, Ioannidis JPA, Tsatsoulis A (2002) Association of polymorphisms of the estrogen receptor gene with the age of menarche. Hum Reprod 17:1101–1105

    Article  CAS  PubMed  Google Scholar 

  7. Parent A-S, Teilmann G, Juul A, Skakkebaek NE, Toppari J, Bourguignon J-P (2003) The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocr Rev 24(5):668–693

    Article  PubMed  Google Scholar 

  8. Kaplan SL, Grumbach MM (1990) Pathogenesis of sexual precocity. In: Grumbach MM, Sizonenko PC, Aubert ML (eds) Control of the onset of puberty. Williams and Wilkins, Baltimore, pp 620–660

    Google Scholar 

  9. Smail PJ, Faiman C, Hobson WC et al (1982) Further studies on adrenarche in nonhuman primates. Endocrinology 111:844–848

    Article  CAS  PubMed  Google Scholar 

  10. Ebling FJP, Cronin AS (2000) The neurobiology of reproductive development. Neuroreport 11:R23–R33

    Article  CAS  PubMed  Google Scholar 

  11. Bourguignon JP, Lebrethon MC (2000) Le primum movens du déclenchement puber-taire: signaux hypothalamiques, périphériques et environnementaux. J Gynecol Obstet Biol Reprod 29:295–297

    CAS  Google Scholar 

  12. Smith R, Mesiano S, Chan EC et al (1998) Corticotropin – releasing hormon directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells. J Clin Endocrinol Metab 83:2916–2920

    CAS  PubMed  Google Scholar 

  13. Biason-Lauber A, Zachmann M, Schoenle EJ (2000) Effect of leptin on CYP17 enzymatic activities in human adrenal cells: new insight in the onset of adrenarche. Endocrinology 141:1446–1454

    CAS  PubMed  Google Scholar 

  14. Crofton PM, Illingworth PJ, Groome NP et al (1997) Changes in dimeric inhibin A and B during normal early puberty in boys and girls. Clin Endocrinol 46(1):109–114

    Article  CAS  Google Scholar 

  15. Leyendecker G, Wildt L (1996) From physiology to clinics – 29 years of experience with pulsatile GnRH. Eur J Obstet Gynecol Reprod Biol 65:S3–S12

    Article  CAS  PubMed  Google Scholar 

  16. Leyendecker G (1978) Die normoprolaktinämische sekundäre Ovarialinsuffizienz; Pathophysiologie, Diagnostik und Therapie. Arch Gynecol 228:503–517

    Article  Google Scholar 

  17. Hadžiomerović D, Wildt L (2006) Hypothalamische Ovarialinsuffizienz. Gynäkologische Endokrinologie 4:27–32

    Article  CAS  Google Scholar 

  18. Ojeda SR, Hill J, Hill DF et al (1999) The Oct-2 POU-domain gene in the neuroendocrine brain: a transcriptional regulator of mammalian puberty. Endocrinology 140:3774–3789

    CAS  PubMed  Google Scholar 

  19. Lee BJ, Cho GJ, Norgren R et al (2001) TTF-1, a homeodomain gene required for di-encephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. Mol Cell Neurosci 17:107–126

    Article  CAS  PubMed  Google Scholar 

  20. Rampazzo A, Pivotto F, Occhi G et al (2000) Characterization of C14orf4, a novel intron-less human gene containing a polyglutamine repeat, mapped to the ARVD1 critical region. Biochem Biophys Res Commun 278:766–774

    Article  CAS  PubMed  Google Scholar 

  21. Heger S, Mastronardi C, Dissen GA et al (2007) Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis. J Clin Invest 117(8):2145–2154

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Ohtaki T, Shintani Y, Honda S et al (2001) Metastasis suppressor gene KiSS-1 encodes peptides ligand of a G-protein-coupled receptor. Nature 411:613–617

    Article  CAS  PubMed  Google Scholar 

  23. Steeg PS, Ouatas T, Halverson D et al (2003) Metastasis suppressor genes : basic biology and potential clinical use. Clin Breast Cancer 4:51–62

    Article  CAS  PubMed  Google Scholar 

  24. Shahab M, Mastronardi C, Seminara SB et al (2005) Increased hypothalamic GPR-54 signaling: a potential mechanism for initiation of puberty in primates. Proc Natl Acad Sci U S A 102:2129–2134

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Irwig MS, Fraley GS, Smith JT et al (2005) Kisspeptin activation of gonadotropine releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology 80:264–272

    Article  CAS  Google Scholar 

  26. Gottsch ML, Cunninghanam MJ, Smith JT et al (2004) A role for kisspeptins in the regulation of gonadotropine secretion in the mouse. Endocrinology 145:4073–4077

    Article  CAS  PubMed  Google Scholar 

  27. Muir AI, Chamberlain L, Elshourbagy NA et al (2001) AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem 276:28969–28975

    Article  CAS  PubMed  Google Scholar 

  28. Kotani M, Detheux M, Vandenbogaerde A et al (2001) The metastasis suppressor genes KiSS-1 encodes kisspeptins, the naturals ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem 276:34631–34636

    Article  CAS  PubMed  Google Scholar 

  29. Tena-Sempere M (2006) GPR54 and kisspeptin in reproduction. Hum Reprod Update 12:631–639

    Article  CAS  PubMed  Google Scholar 

  30. Navarro VM, Castellano JM, Fernandez-Fernandez R et al (2004) Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. J Physiol 561:379–386

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Han SK, Gottsch ML, Lee KJ et al (2005) Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci 25:11349–11356

    Article  CAS  PubMed  Google Scholar 

  32. Smith JT, Cunningham MJ, Rissman EF et al (2005) Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology 146:3686–3692

    Article  CAS  PubMed  Google Scholar 

  33. Smith JT, Dungan HM, Stol EA et al (2005) Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology 146:2976–2984

    Article  CAS  PubMed  Google Scholar 

  34. Castellano JM, Navarro VM, Fernandez-Fernandez R et al (2005) Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology 146:3917–3925

    Article  CAS  PubMed  Google Scholar 

  35. Cunningham MJ, Clifton DK, Steiner RA (1999) Leptin’s actions on the reproductive axis: perspectives and mechanisms. Biol Reprod 60:616–622

    Article  Google Scholar 

  36. Ojeda SR, Lomniczi A, Mastronardi C (2006) Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach? Endocrinology 147:1166–1174

    Article  CAS  PubMed  Google Scholar 

  37. Tena-Sempere M (2005) Hypothalamic KiSS-1: the missing link in gonadotropine feed-back control? Endocrinology 146:3683–3685

    Article  CAS  PubMed  Google Scholar 

  38. Clement K, Vaisse C, Lahlou N et al (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392:398–401

    Article  CAS  PubMed  Google Scholar 

  39. Azziz R (1989) Reproductive endocrinologic alterations in female asymptomatic obesity. Fertil Steril 52:703–725

    Article  CAS  PubMed  Google Scholar 

  40. Bussen S, Sutterlin M, Steck T (1999) Endocrine abnormalities during the follicular phase in women with recurrent spontaneous abortion. Hum Reprod 14:18–20

    Article  CAS  PubMed  Google Scholar 

  41. Mann DR, Johnson A, Gimpel T, Castracane D (2003) Changes in circulating leptin, leptin receptor, and gonadal hormones from infancy until advanced age in humans. J Clin Endocrinol Metab 88:3339–3345

    Article  CAS  PubMed  Google Scholar 

  42. Grumbach MM, Styne DM (1998) Puberty: ontogeny, neuroendocrinology, physiology, and disorders. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR (eds) Williams textbook of endocrinology, 9th edn. WB Saunders Company, Philadelphia, pp 1509–1625

    Google Scholar 

  43. Byrd W, Bennett MJ, Carr BR, Dong Y, Wians F, Rainey W (1998) Regulation of biologically active dimeric inhibin A and B from infancy to adulthood in the male. J Clin Endocrinol Metab 83(8):2849–2854

    Article  CAS  PubMed  Google Scholar 

  44. Phillips DJ, de Kretser DM (1998) Follistatin: a multifunctional regulatory protein. Front Neuroendocrinol 19:287–322

    Article  CAS  PubMed  Google Scholar 

  45. Foster CM, Phillips DJ, Wyman T, Evans LW, Groome NP, Padmanabhan V (2000) Changes in serum inhibin, activin and follistatin concentrations during puberty in girls. Hum Reprod 15(5):1052–1057

    Article  CAS  PubMed  Google Scholar 

  46. Meachem SJ, Nieschlag E, Simoni M (2001) Inhibin B in male reproduction: pathophysiology and clinical relevance. Eur J Endocrinol 145:561–571

    Article  CAS  PubMed  Google Scholar 

  47. Horlick MB, Rosenbaum MN, Levine LS et al (2000) Effect of puberty on the relationship between circulating leptin and body composition. J Clin Endocrinol Metab 85:2509–2518

    CAS  PubMed  Google Scholar 

  48. Ghizzoni L, Barreca A, Mastorakos G et al (2001) Leptin inhibits steroid biosynthesis by human granulosa-lutein cells. Horm Metab Res 33:323–328

    Article  CAS  PubMed  Google Scholar 

  49. Ibanez L, Virdis R, Potau N et al (1992) Natural history of premature pubarche : an auxological study. J Clin Endocrinol Metab 74:254–257

    CAS  PubMed  Google Scholar 

  50. Wickman S, Saukkonen T, Dunkel L (2002) The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor. Eur J Endocrinol 146:339–346

    Article  CAS  PubMed  Google Scholar 

  51. Bottner A, Kratzsch J, Muller G, Kapellen TM, Bluher S, Keller E, Bluher M, Kiess W (2004) Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab 89:4053–4061

    Article  PubMed  CAS  Google Scholar 

  52. Winter S, Ousidhoum A, McElreavey K, Raja Brauner R (2016) Constitutional delay of puberty: presentation and inheritance pattern in 48 familial cases. BMC Pediatr 16:37–44

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  53. Herman-Giddens ME, Slora EJ, Wasserman RC et al (1997) Secondary sexual characteristics and menses in young girls seen in office practice: a study from the pediatric research in office settings network. Pediatrics 99:505–512

    Article  CAS  PubMed  Google Scholar 

  54. Kaplowitz PB, Oberfield SE, Drug and Therapeutics and Executive Committees of the Lawson Wilkins Pediatric Endocrine Society (1999) Reexamination of the age limit for defining when puberty is precocious in girls in the United States: implications for evaluation and treatment. Pediatrics 104:936–941

    Article  CAS  PubMed  Google Scholar 

  55. Brämswig J, Dübbers A (2009) Disorders of pubertal development. Dtsch Arztebl Int 106(17):295–304

    PubMed  PubMed Central  Google Scholar 

  56. Kaplowitz P (2004) Clinical characteristics of 104 children referred for evaluation of precocious puberty. J Clin Endocrinol Metab 89:3644–3650

    Article  CAS  PubMed  Google Scholar 

  57. Kahl HSRA, Schlaud M (2007) Sexuelle Reifung von Kindern und Jugendlichen in Deutschland. Ergebnisse des Kinder- und Jugendgesundheitssurveys (KiGGS). Bundesgesundheitsbl-Gesundheitsforsch-Gesundheitsschutz 50:677–685

    Article  CAS  Google Scholar 

  58. Reindollar RH, Tho SPT, McDonough PG (1989) Delayed puberty: an updated study of 326 patients. Trans Am Gynecol Obstet Soc 8:146–162

    Google Scholar 

  59. Harrington J, Palmert MR (2012) Distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism: critical appraisal of available diagnostic tests. J Clin Endocrinol Metab 97:3056–3067

    Article  CAS  PubMed  Google Scholar 

  60. Lunsford AJ, Whelan K, McCormick K, McLaren JF (2014) Antimüllerian hormone as a measure of reproductive function in female childhood cancer survivors. Fertil Steril 101:227–231. pii: S0015-0282(13)03018-5

    Google Scholar 

  61. Traggiai C, Stanhope R (2003) Disorders of pubertal development. Best Pract Res Clin Obstet Gynaecol 17(1):41–56

    Article  CAS  PubMed  Google Scholar 

  62. Yollin E, Jonard S, Reyss A-C et al (2006) Delayed puberty with extreme uterine hypotrophy: do not conclude too early to the absence of the uterus. Gynecol Obstet Fertil 34:1029–1035

    Article  CAS  PubMed  Google Scholar 

  63. Stanhope R, Adams J, Jacobs HS, Brook CG (1985) Ovarian ultrasound assessment in normal children, idiopathic precocious puberty, and during low-dose pulsatile gonadotrophin-releasing hormone treatment of hypogonadotrophic hypogonadism. Arch Dis Child 60:116–119

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Dwyer AA, Phan-Hug F, Hauschild M, Elowe-Gruau E, Pitteloud N (2015) Hypogonadism in adolescence. Eur J Endocrinol 173:R15–R24

    Article  CAS  PubMed  Google Scholar 

  65. Palmert MR, Dunkel L (2012) Clinical practice. Delayed puberty. N Engl J Med 366:443–453

    Article  CAS  PubMed  Google Scholar 

  66. Sedlmeyer IL, Palmert MR (2002) Delayed puberty: analysis of a large case series from an academic center. J Clin Endocrinol Metabol 87:1613–1620

    Article  CAS  Google Scholar 

  67. Bonjour J-P (1998) Delayed puberty and peak bone mass. Eur J Endocrinol 139:257–259

    Article  CAS  PubMed  Google Scholar 

  68. Bertelloni S, Baroncelli GI, Ferdeghini M, Perri G, Maggese G (1998) Normal volumetric bone mineral density and bone turnover in young men with histories of constitutional delay of puberty. J Clin Endocrinol Metab 83:4280–4283

    Article  CAS  PubMed  Google Scholar 

  69. Gourmelen M, Pham-Huu-Trung MT, Girard F (1979) Transient partial GH deficiency in prepubertal children with delay of growth. Pediatr Res 13:221–224

    Article  CAS  PubMed  Google Scholar 

  70. Lanes R, Bohorquez MDSL, Leal V, Hernandez G, Borges M, Hurtado E et al (1986) Growth hormone secretion in patients with constitutional delay of growth and pubertal development. J Pediatr 109:781–783

    Article  CAS  PubMed  Google Scholar 

  71. Reiter EO, Lee PA (2002) Delayed puberty. Adolesc Med 13(1):101–118

    PubMed  Google Scholar 

  72. Reiter EO, Kaplan SL, Conte FA, Grumbach MM (1975) Resposivity of pituitary gonadotropins to luteinizing hormone-releasing factor in idiopathic precocious puberty, precocious thelarche, precocious adrenarche and in patients treated with medroxyprogesterone acetate. Pediatr Res 9:111–115

    Article  CAS  PubMed  Google Scholar 

  73. Bierich JR (1989) Therapy with growth hormone – old and new indications. Horm Res 32:153–165

    Article  CAS  PubMed  Google Scholar 

  74. Loche S, Cambiaso M, Setzu S et al (1994) Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature. J Pediatr 125:196–200

    Article  CAS  PubMed  Google Scholar 

  75. Bernasconi S, Street ME, Volta C, Mazzardo G (1997) Final height in non-growth hor-mone deficient children treated with growth hormone. The Italian multicentre study group. Clin Endocrinol 47(3):261–266

    Article  CAS  Google Scholar 

  76. Quinton R, Duke VM, Robertson A et al (2001) Idiopathic gonadotrophin deficiency: genetic questions addressed through phenotypic characterization. Clin Endocrinol (Oxf) 55:163–174

    Article  CAS  Google Scholar 

  77. Brioude F, Bouligand J, Trabado S et al (2010) Non- syndromic congenital hypogonadotropic hypogonadism: clinical presentation and genotype–phenotype relationships. Eur J Endocrinol 162:835–851

    Article  CAS  PubMed  Google Scholar 

  78. Lewkowitz-Shpuntoff HM, Hughes VA, Plummer L et al (2012) Olfactory phenotypic spectrum in idiopathic hypogonadotropic hypogonadism: pathophysiological and genetic implications. J Clin Endocrinol Metabol 97:E136–E144

    Article  CAS  Google Scholar 

  79. de Morsier G (1962) Median cranioencephalic dysraphias and olfactogenital dysplasias. World Neurol 3:485–506

    Google Scholar 

  80. Villanueva C, Argente J (2014) Pathology or normal variant: what constitutes a delay in puberty? Horm Res Paediatr 82:213–221

    Article  CAS  PubMed  Google Scholar 

  81. Mitchell AL, Dwyer A, Pitteloud N, Quinton R (2011) Genetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory. Trends Endocrinol Metab 22:249–258

    CAS  PubMed  Google Scholar 

  82. Raivio T, Avbelj M, McCabe MJ, Romero CJ, Dwyer AA, Tommiska J, Sykiotis GP, Gregory LC, Diaczok D, Tziaferi V et al (2012) Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia. J Clin Endocrinol Metabol 97:E694–E699

    Article  CAS  Google Scholar 

  83. Jongmans MC, van Ravenswaaij-Arts CM, Pitteloud N, Ogata T, Sato N, Claahsen-van der Grinten HL, van der Donk K, Seminara S, Bergman JE, Brunner HG et al (2009) CHD7 mutations in patients initially diagnosed with Kallmann syndrome-the clinical overlap with CHARGE syndrome. Clin Genet 75:65–71

    Article  CAS  PubMed  Google Scholar 

  84. Thébaut A, Amouyal M, Besançon A et al (2013) Puberty, fertility and chronic diseases. Arch Pediatr 20(6):673–684

    Article  PubMed  Google Scholar 

  85. Codner E, Merino PM, Tena-Sempere M (2012) Female reproduction and type 1 diabetes: from mechanisms to clinical findings. Hum Reprod Update 18:568–585

    Article  CAS  PubMed  Google Scholar 

  86. Schweiger BM, Snell-Bergeon JK, Roman R et al (2011) Menarche delay and menstrual irregularities persist in adolescents with type 1 diabetes. Reprod Biol Endocrinol 9:61–68

    Article  PubMed  PubMed Central  Google Scholar 

  87. Munoz MT, Argente J (2002) Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances. Eur J Endocrinol 147:275–286

    Article  CAS  PubMed  Google Scholar 

  88. Roth D, Meyer Egli C, Kriemler S, Birkhäuser M et al (2000) Female athlete triad. Schweizerische Zeitschrift für Sportmedizin und Sporttraumatologie 48(3):119–132

    Google Scholar 

  89. Jackman S, Diamond F (2013) Pituitary adenomas in childhood and adolescence. Pediatr Endocrinol Rev 10:450–459

    PubMed  Google Scholar 

  90. Armstrong GT, Chow EJ, Sklar CA (2009) Alterations in pubertal timing following therapy for childhood malignancies. Endocr Dev 15:25–39

    PubMed  Google Scholar 

  91. Muller J (2002) Disturbance of pubertal development after cancer treatment. Best practice & research. Clin Endocrinol Metab 16:91–103

    Google Scholar 

  92. Lenz AM, Root AW (2012) Empty sella syndrome. Pediatr Endocrinol Rev 9(4):710–715

    PubMed  Google Scholar 

  93. Colao A, Savastano S (2011) Medical treatment of prolactinomas. Nat Rev Endocrinol 7:267–278

    Article  CAS  PubMed  Google Scholar 

  94. Park JK, Lee EJ, Kim SH (2012) Optimal surgical approaches for Rathke cleft cyst with consideration of endocrine function. Neurosurgery 70:250–257

    PubMed  Google Scholar 

  95. Zada G, Laws ER (2010) Surgical management of craniopharyngiomas in the pediatric population. Horm Res Paediatr 74:62–66

    Article  CAS  PubMed  Google Scholar 

  96. Chandler WF, Barkan AL (2008) Treatment of pituitary tumors: a surgical perspective. Endocrinol Metab Clin North Am 37:51–66

    Article  PubMed  Google Scholar 

  97. Easter A, Treasure J, Micali N (2011) Fertility and prenatal attitudes towards pregnancy in women with eating disorders: results from the Avon Longitudinal Study of Parents. BJOG 118(12):1491–1498

    Article  CAS  PubMed  Google Scholar 

  98. Bulik CM, Sullivan PF, Fear JL et al (1999) Fertility and reproduction in women with anorexia nervosa: a controlled study. J Clin Psychiatry 60(2):130–135

    Article  CAS  PubMed  Google Scholar 

  99. Micali N, dos-Santos-Silva I, De Stavola B et al (2014) Fertility treatment, twin births, and unplanned pregnancies in women with eating disorders: findings from a population-based birth cohort. BJOG 121:408–416

    Article  CAS  PubMed  Google Scholar 

  100. Leyendecker G, Wildt L (1982) Pulsatile treatment with gonadotropin-releasing hormone (Gn-Rh). Geburtsh Frauenheilk 42:689–699

    Article  CAS  PubMed  Google Scholar 

  101. Birkhäuser MH (1989) Pulsatile Therapie mit LH-RH. Arch Gynecol Obstet 246(Suppl 1):38–44

    Article  Google Scholar 

  102. Lunenfeld B, Insler V (1995) In: Wallach EE, Zacur HE (eds) Reproductive medicine and surgery. Mosby-Year Book, St. Louis, p 617

    Google Scholar 

  103. Wildt L, Leyendecker G (1987) Induction of ovulation by the chronic administration of naltrexone in hypothalamic amerorrhea. J Clin Endocrinol Metabol 64:1334–1335

    Article  CAS  Google Scholar 

  104. Bondy CA, The Turner Syndrome Consensus Study Group* Clinical Practice Guideline (2007) Care of girls and women with turner syndrome: a guideline of the turner syndrome study group. J Clin Endocrinol Metab 92:10–25

    Article  CAS  PubMed  Google Scholar 

  105. Gibbons B, Tan SY, Yu CC-W et al (1999) Risk of gonadoblastoma in female patients with Y chromosome abnormalities and dysgenetic gonads. J Paediatr Child Health 35:210–213

    Article  CAS  PubMed  Google Scholar 

  106. Meyer L, Birkhäuser MH, Bühler E, Pavic N (1989) Fertilität und Turner-Mosaik-Syndrom. Geburtsh Frauenheilk 49:825–829

    Article  CAS  PubMed  Google Scholar 

  107. von Wolff M et al (2015) Fertility-preservation counselling and treatment for medical reasons: data from a multinational network of over 5000 women. Reprod Biomed Online 31(5):605–612

    Article  Google Scholar 

  108. Jadoul P, Dolmans MM, Donnez J (2010) Fertility preservation in girls during childhood: is it feasible, efficient and safe and to whom should it be proposed? Hum Reprod Update 16:617–630

    Article  PubMed  Google Scholar 

  109. Aittomäki K (1994) The genetics of XX gonadal dysgenesis. Am J Hum Genet 54:844–851

    PubMed  PubMed Central  Google Scholar 

  110. Hawkins JR, Taylor A, Goodfellow PN et al (1992) Evidence for increased prevalence of SRY mutations in XY females with complete rather than partial gonadal dysgenesis. Am J Hum Genet 51:979–984

    CAS  PubMed  PubMed Central  Google Scholar 

  111. Cornet D, Alvarez S, Antoine JM et al (1990) Pregnancies following ovum donation in gonadal dysgenesis. Hum Reprod 5(3):291–293

    Article  CAS  PubMed  Google Scholar 

  112. Ankarberg-Lindgren C, Westphal O, Dahlgren J (2011) Testicular size development and reproductive hormones in boys and adult males with Noonan syndrome: a longitudinal study. Eur J Endocrinol 165:137–144

    Article  CAS  PubMed  Google Scholar 

  113. Ineke van der Burgt I (2007) Review: Noonan syndrome. Orphanet J Rare Dis:2–4. doi:10.1186/1750-1172-2-4

  114. Oakes MB, Eyvazzadeh AD, Quint E, Smith YR (2008) Complete androgen insensitivity syndrome—a review. J Pediatr Adolesc Gynecol 21:305–310

    Article  PubMed  Google Scholar 

  115. Toledo SPA, Bruner HG, Kraaij R et al (1996) An inactivating mutation of the LH receptor causes amenorrhea in a 46, XX female. J Clin Endocrinol Metab 82:3850–3854

    Google Scholar 

  116. Latronico AC, Arnhold IJ (2006) Inactivating mutations of LH and FSH receptors--from genotype to phenotype. Pediatr Endocrinol Rev 4:28–31

    PubMed  Google Scholar 

  117. Huhtaniemi IT (2002) LH and FSH receptor mutations and their effects on puberty. Horm Res 57(suppl 2):35–38

    CAS  PubMed  Google Scholar 

  118. Arnhold IJ, Lofrano-Porto A, Latronico AC (2009) Inactivating mutations of luteinizing hormone-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. Horm Res 71:75–82

    CAS  PubMed  Google Scholar 

  119. Raga F, Bauset C, Remohi J et al (1997) Reproductive impact of congenital Müllerian anomalies. Hum Reprod 12:2277–2281

    Article  CAS  PubMed  Google Scholar 

  120. Aittomäki K, Herva R, Stenman U-H et al (1996) Clincal features of primary ovarian filkaure caused by a point mutation in the FSH receptor gene. J Clin Endocrinol Metab 81:3722–3726

    PubMed  Google Scholar 

  121. Meduri G, Touraine P, Beau I et al (2003) Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies. J Clin Endocrinol Metab 88:3491–3498

    Article  CAS  PubMed  Google Scholar 

  122. Achrekar SK, Modi DN, Meherji PK et al (2010) Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorrhea. J Assist Reprod Genet 27:317–326

    Article  PubMed  PubMed Central  Google Scholar 

  123. Fridovich-Keil J, Gubbels CS, Spencer JB et al (2011) Ovarian function in girls and women with GALT-deficiency galactosemia. Galactosemia J Inherit Metab Dis 34:357–366

    Article  CAS  PubMed  Google Scholar 

  124. Gubbels GC, Land JA, Rubio-Gozalbo ME (2008) Fertility and impact of pregnancies on the mother and child in classic galactosemia. Obstet Gynecol Surv 63(5):334–343

    Article  PubMed  Google Scholar 

  125. Singh KL, Davies M, Chatterjee R (2005) Fertility in female cancer survivors: pathophysiology, preservation and the role of ovarian reserve testing. Hum Reprod Update 11:69–89

    Article  Google Scholar 

  126. Bath LE, Wallace WH, Critchley HO (2002) Late effects of the treatment of childhood cancer on the female reproductive system and the potential for fertility preservation. Br J Obstet Gynaecol 109:107–114

    Article  Google Scholar 

  127. Smith MA, Seibel NL, Altekruse SF et al (2010) Outcomes for children and adolescents with cancer: challenges for the twenty-first century. J Clin Oncol 28:2625–2634

    Article  PubMed  PubMed Central  Google Scholar 

  128. Green DM, Sklar CA, Boice CD et al (2009). Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor study. Clin Oncol 27:2374–2381

    Google Scholar 

  129. Anderson RA, Wallace WHB (2011) Fertility preservation in girls and young women. Clin Endocrinol (Oxf) 75:409–419

    Article  Google Scholar 

  130. Brougham MFH, Wallace WHB (2005) Subfertility in children and young people treated for solid and haematological malignancies. Br J Haematol 131:143–155

    PubMed  Google Scholar 

  131. Meirow D, Biedermann H, Anderson RA, Wallace WHB (2010) Toxicity of chemotherapy and radiation on female reproduction. Clin Obstet Gynecol 53:727–739

    Article  PubMed  Google Scholar 

  132. Irtan S, Orbach D, Helfre S, Sarnacki S (2013) Ovarian transposition in prepubescent and adolescent girls with cancer. Lancet Oncol 14:601–608

    Article  Google Scholar 

  133. Bines J, Oleske DM, Cobleigh MA (1996) Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol 14:1718–1729

    CAS  PubMed  Google Scholar 

  134. Byrne J, Fears TR, Gail MH et al (1992) Early menopause in long-term survivors of cancer during adolescence. Am J Obstet Gynecol 166:788–793

    Article  CAS  PubMed  Google Scholar 

  135. Wallace WHB (2011) Oncofertility and preservation of reproductive capacity in children and young adults. Cancer 117(10 suppl):2301–2310

    Article  PubMed  Google Scholar 

  136. Wallace WH, Thomson AB, Saran F, Kelsey TW (2005) Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys 62:738–744

    Article  PubMed  Google Scholar 

  137. Wallace WH, Thomson AB, Kelsey TW (2003) The radiosensitivity of the human oocyte. Hum Reprod 18:117–121

    Article  CAS  PubMed  Google Scholar 

  138. Brougham MF, Crofton PM, Johnson EJ, Evans N, Anderson RA, Wallace WH (2012) Anti-Müllerian hormone is a marker of gonadotoxicity in pre- and postpubertal girls treated for cancer: a prospective study. J Clin Endocrinol Metab 97:2059–2067

    Article  CAS  PubMed  Google Scholar 

  139. Wallace WHB, Anderson RA (2013) Antimüllerian hormone, the assessment of the ovarian reserve, and the reproductive outcome of the young patient with cancer. Fertil Steril 99:1469–1475

    Article  PubMed  CAS  Google Scholar 

  140. Larsen EC, Muller J, Schmiegelow K, Rechnitzer C, Andersen AN (2003) Reduced ovarian function in long-term survivors of radiation- and chemotherapy-treated childhood cancer. J Clin Endocrinol Metab 88:5307–5314

    Article  CAS  PubMed  Google Scholar 

  141. von Wolff M (ed) (2016) Perspektive Fertilität Indikation und Durchführung fertilitätsprotektiver Massnahmen bei onkologischen und nicht-onkologischen Erkrankungen. Schmidt & Klaunig, Druckerei und Verlag, Kiel, 1. Auflage. ISBN-Nr.: 978-3-88312-127-7

    Google Scholar 

  142. Anderson RA, Wallace WH, Baird DT (2008) Ovarian cryopreservation for fertility preservation: indications and outcomes. Reproduction 136:681–689

    Article  CAS  PubMed  Google Scholar 

  143. Michaeli J, Weintraub M, Gross E et al (2012) Fertility preservation in girls. Obstet Gynecol Int 2012. Article ID 139193, 10 pages

    Google Scholar 

  144. Wallace WHB, Grove Smith A, Kelsey TW, Edgar AE, Anderson RA (2014) Fertility preservation for girls and young women with cancer: population-based validation of criteria for ovarian tissue cryopreservation. Lancet Oncol 15:1129–1136

    Article  PubMed  PubMed Central  Google Scholar 

  145. Wallace WHB, Barr RD (2010) Fertility preservation for girls and young women with cancer: what are the remaining challenges? Hum Reprod Update 16:614–616

    Article  CAS  PubMed  Google Scholar 

  146. Oktem O et al (2015) Ovarian function and reproductive outcomes of female patients with systemic lupus erythematodes and the strategies to preserve their fertility. Obstet Gynecol Surv 70(3):196–210

    Article  PubMed  Google Scholar 

  147. Wallace WHB, Critchley HOD, Anderson RA (2012) Optimizing reproductive outcome in children and young people with cancer. J Clin Oncol 30:3–5

    Article  PubMed  Google Scholar 

  148. Oezen S, Darcan S (2011) Effects of environmental endocrine disruptors on pubertal development. J Clin Res Pediatr Endocrinol 3(1):1–6

    Article  Google Scholar 

  149. Buck Louis GM, Gray LE, Marcus M et al (2008) Environmental factors and puberty timing: expert panel research needs. Pediatrics 121(Supplement 3):S192–S207

    Article  PubMed  Google Scholar 

  150. Den Hond E, Roels HA, Hoppenbrouwers K et al (2002) Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek’s hypothesis revisited. Environ Health Perspect 110:771–776

    Article  Google Scholar 

  151. Leijs MM, Koppe JG, Olie K et al (2008) Delayed initiation of breast development in girls with higher prenatal dioxin exposure; a longitudinal cohort study. Chemosphere 37(6):999–1004

    Article  CAS  Google Scholar 

  152. Wu T, Buck GM, Mendola P (2003) Blood lead levels and sexual maturation in US girls: the Third National Health and Nutrition Examination Survey, 1988–1994. Environ Health Perspect 111:737–741

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  153. Selevan SG, Rice DC, Hogan KA, Euling SY, Pfahles-Hutchens A, Bethel J (2003) Blood lead concentration and delayed puberty in girls. N Engl J Med 348:1527–1536

    Article  CAS  PubMed  Google Scholar 

  154. Canfield RL, Henderson CR, Cory-Slechta DA et al (2003) Intellectual impairment in children with blood lead concentrations below 10 μg per deciliter. N Engl J Med 348(16):1517–1526

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  155. Beier KM, Bosinski HA, Loewit K (2005) Sexualmedizin, 2nd edn. Urban & Fischer, München

    Google Scholar 

  156. Leyendecker G, Wildt L, Plotz EJ (1982) Gynäkologe 14:84

    Google Scholar 

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  1. Gynaecological Endocrinology and Reproductive Medicine, University of Berne, Gartenstrasse 67, Basel, 4052, Switzerland

    Martin Birkhaeuser

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  1. Martin Birkhaeuser
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  1. Département Hormonologie Hôpital Lapeyronie CHU et Université Montpellier, Unité d’Endocrinologie et Gynécologie Pédiatriques, Département de Pédiatrie Hôpital Arnaud-de-Villeneuve CHU et Université Montpellier, Montpellier, France

    Charles Sultan

  2. International Society of Gynecological Endocrinology, Pisa, Italy

    Andrea R. Genazzani

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Birkhaeuser, M. (2017). Delayed Puberty: Impact on Female Fertility. In: Sultan, C., Genazzani, A. (eds) Frontiers in Gynecological Endocrinology. ISGE Series. Springer, Cham. https://doi.org/10.1007/978-3-319-41433-1_11

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