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Nanoparticles for Cardiovascular Imaging with CT

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Design and Applications of Nanoparticles in Biomedical Imaging

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Abstract

Complications involved with the progression of atherosclerosis in the coronary arteries are responsible for the majority of deaths related to cardiovascular disease. Clinically, X-ray computed tomography (CT) plays a key role in the assessment of atherosclerosis but current iodinated contrast agents relied upon for CT applications suffer from fast clearance, biocompatibility issues, and nonspecific uptake. Nanotechnologies have presented solutions to these problems by offering precise control over the properties of novel contrast agents. In this chapter, we discuss nanoparticle CT contrast agents that have been used for cardiovascular imaging. We cover iodinated and inorganic nanoparticle structures including nano-emulsions, liposomes, micelles, dendrimers, solid metal core nanoparticles, and others and discuss their applications for vascular and target specific imaging. Tremendous progress has been made in the field over the past decade and we expect that the next decade will see the clinical translation of nanoparticle formulations among many additional technological advances.

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Acknowledgments

This work was supported by R01 HL131557 (D.P.C.), R00 EB012165 (D.P.C.), W. W. Smith Charitable Trust (D.P.C.), and the T32 HL007954 (P.C.). We also thank the University of Pennsylvania for startup funding.

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Authors and Affiliations

  1. Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA

    Peter Chhour, Rabe’e Cheheltani, Pratap C. Naha, Harold I. Litt, Victor A. Ferrari & David P. Cormode

  2. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA

    Peter Chhour & David P. Cormode

  3. Division of Cardiovascular Medicine, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein, Philadelphia, PA, 19104, USA

    Harold I. Litt, Victor A. Ferrari & David P. Cormode

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  1. Peter Chhour
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  2. Rabe’e Cheheltani
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  3. Pratap C. Naha
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  4. Harold I. Litt
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  5. Victor A. Ferrari
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  6. David P. Cormode
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Correspondence to David P. Cormode .

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  1. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Jeff W.M. Bulte

  2. Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Michel M.J. Modo

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Chhour, P., Cheheltani, R., Naha, P.C., Litt, H.I., Ferrari, V.A., Cormode, D.P. (2017). Nanoparticles for Cardiovascular Imaging with CT. In: Bulte, J., Modo, M. (eds) Design and Applications of Nanoparticles in Biomedical Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-42169-8_17

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