Skip to main content
SpringerLink
Log in

Nanoformulations for Pharmacological siRNA Delivery in Cancer

  • Chapter
  • First Online:
Design and Applications of Nanoparticles in Biomedical Imaging

Abstract

A wide range of nanoparticles has been investigated for the delivery of siRNAs into desired organs in vivo. The formulations include liposomes/polymeric nanoparticles, polyplexes, and organic/inorganic nanoparticles. The physicochemical properties, i.e., particle sizes, surface coatings, and compositions of nanoparticles have been adjusted for enhanced delivery of siRNA. In this chapter, the chemistry of these nanoformulations is reviewed with particular relevance to cancer treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391(6669):806–11.

    Article  CAS  PubMed  Google Scholar 

  2. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2001;411(6836):494–8.

    Article  CAS  PubMed  Google Scholar 

  3. McCaffrey AP, Meuse L, Pham T-TT, Conklin DS, Hannon GJ, Kay MA. Gene expression: RNA interference in adult mice. Nature. 2002;418(6893):38–9.

    Article  CAS  PubMed  Google Scholar 

  4. Kanasty R, Dorkin JR, Vegas A, Anderson D. Delivery materials for siRNA therapeutics. Nat Mater. 2013;12(11):967–77.

    Article  CAS  PubMed  Google Scholar 

  5. Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M, et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature. 2004;432(7014):173–8.

    Article  CAS  PubMed  Google Scholar 

  6. Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol. 2005;23(4):457–62.

    Article  CAS  PubMed  Google Scholar 

  7. Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, et al. Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med. 2005;11(3):263–70.

    Article  CAS  PubMed  Google Scholar 

  8. Stylianopoulos T, Poh M-Z, Insin N, Bawendi MG, Fukumura D, Munn LL, et al. Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions. Biophys J. 2010;99(5):1342–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lin Q, Chen J, Zhang Z, Zheng G. Lipid-based nanoparticles in the systemic delivery of siRNA. Nanomedicine. 2014;9(1):105–20.

    Article  CAS  PubMed  Google Scholar 

  10. Kanasty RL, Whitehead KA, Vegas AJ, Anderson DG. Action and reaction: the biological response to siRNA and its delivery vehicles. Mol Ther. 2012;20(3):513–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Aird WC. Phenotypic heterogeneity of the endothelium I. Structure, function, and mechanisms. Circ Res. 2007;100(2):158–73.

    Article  CAS  PubMed  Google Scholar 

  12. Wisse E, Jacobs F, Topal B, Frederik P, De Geest B. The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer. Gene Ther. 2008;15(17):1193–9.

    Article  CAS  PubMed  Google Scholar 

  13. Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Ipe BI, et al. Renal clearance of quantum dots. Nat Biotechnol. 2007;25(10):1165–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Singh S, Sharma A, Robertson GP. Realizing the clinical potential of cancer nanotechnology by minimizing toxicologic and targeted delivery concerns. Cancer Res. 2012;72(22):5663–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Cabral H, Matsumoto Y, Mizuno K, Chen Q, Murakami M, Kimura M, et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol. 2011;6(12):815–23.

    Article  CAS  PubMed  Google Scholar 

  16. Zintchenko A, Philipp A, Dehshahri A, Wagner E. Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity. Bioconjug Chem. 2008;19(7):1448–55.

    Article  CAS  PubMed  Google Scholar 

  17. Jäger M, Schubert S, Ochrimenko S, Fischer D, Schubert US. Branched and linear poly (ethylene imine)-based conjugates: synthetic modification, characterization, and application. Chem Soc Rev. 2012;41(13):4755–67.

    Article  PubMed  Google Scholar 

  18. Bonnet M-E, Erbacher P, Bolcato-Bellemin A-L. Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response. Pharm Res. 2008;25(12):2972–82.

    Article  CAS  PubMed  Google Scholar 

  19. Shim MS, Kwon YJ. Acid-responsive linear polyethylenimine for efficient, specific, and biocompatible siRNA delivery. Bioconjug Chem. 2009;20(3):488–99.

    Article  CAS  PubMed  Google Scholar 

  20. Beyerle A, Long AS, White PA, Kissel T, Stoeger T. Poly (ethylene imine) nanocarriers do not induce mutations nor oxidative DNA damage in vitro in MutaMouse FE1 cells. Mol Pharm. 2011;8(3):976–81.

    Article  CAS  PubMed  Google Scholar 

  21. Thomas M, Klibanov AM. Enhancing polyethylenimine’s delivery of plasmid DNA into mammalian cells. Proc Natl Acad Sci. 2002;99(23):14640–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Alshamsan A, Hamdy S, Samuel J, El-Kadi AO, Lavasanifar A, Uludağ H. The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine. Biomaterials. 2010;31(6):1420–8.

    Article  CAS  PubMed  Google Scholar 

  23. Ghonaim HM, Li S, Blagbrough IS. Very long chain N 4, N 9-diacyl spermines: non-viral lipopolyamine vectors for efficient plasmid DNA and siRNA delivery. Pharm Res. 2009;26(1):19–31.

    Article  CAS  PubMed  Google Scholar 

  24. Shen J, Yin Q, Chen L, Zhang Z, Li Y. Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer. Biomaterials. 2012;33(33):8613–24.

    Article  CAS  PubMed  Google Scholar 

  25. Xiao J, Duan X, Yin Q, Miao Z, Yu H, Chen C, et al. The inhibition of metastasis and growth of breast cancer by blocking the NF-kB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles. Biomaterials. 2013;34(21):5381–90.

    Article  CAS  PubMed  Google Scholar 

  26. Huang H, Yu H, Tang G, Wang Q, Li J. Low molecular weight polyethylenimine cross-linked by 2-hydroxypropyl-γ-cyclodextrin coupled to peptide targeting HER2 as a gene delivery vector. Biomaterials. 2010;31(7):1830–8.

    Article  PubMed  Google Scholar 

  27. Dahlman JE, Barnes C, Khan OF, Thiriot A, Jhunjunwala S, Shaw TE, et al. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat Nanotechnol. 2014;9(8):648–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Tang S, Yin Q, Su J, Sun H, Meng Q, Chen Y, et al. Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel. Biomaterials. 2015;48:1–15.

    Article  PubMed  Google Scholar 

  29. Luo G, Jin C, Long J, Fu D, Yang F, Xu J, et al. RNA interference of MBD1 in BxPC-3 human pancreatic cancer cells delivered by PLGA-poloxamer nanoparticles. Cancer Biol Ther. 2009;8(7):594–8.

    Article  CAS  PubMed  Google Scholar 

  30. Pan X, Zhu Q, Sun Y, Li L, Zhu Y, Zhao Z, et al. PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo. Int J Mol Med. 2015;35(4):995–1002.

    CAS  PubMed  Google Scholar 

  31. Liu P, Yu H, Sun Y, Zhu M, Duan Y. A mPEG-PLGA-b-PLL copolymer carrier for adriamycin and siRNA delivery. Biomaterials. 2012;33(17):4403–12.

    Article  CAS  PubMed  Google Scholar 

  32. Liu X-Q, Xiong M-H, Shu X-T, Tang R-Z, Wang J. Therapeutic delivery of siRNA silencing HIF-1 alpha with micellar nanoparticles inhibits hypoxic tumor growth. Mol Pharm. 2012;9(10):2863–74.

    Article  CAS  PubMed  Google Scholar 

  33. Stigliano C, Aryal S, de Tullio MD, Nicchia GP, Pascazio G, Svelto M, et al. siRNA-Chitosan complexes in poly (lactic-co-glycolic acid) nanoparticles for the silencing of aquaporin-1 in cancer cells. Mol Pharm. 2013;10(8):3186–94.

    Article  CAS  PubMed  Google Scholar 

  34. Martin DT, Steinbach JM, Liu J, Shimizu S, Kaimakliotis HZ, Wheeler MA, et al. Surface-modified nanoparticles enhance transurothelial penetration and delivery of survivin siRNA in treating bladder cancer. Mol Cancer Ther. 2014;13(1):71–81.

    Article  CAS  PubMed  Google Scholar 

  35. Techaarpornkul S, Wongkupasert S, Opanasopit P, Apirakaramwong A, Nunthanid J, Ruktanonchai U. Chitosan-mediated siRNA delivery in vitro: effect of polymer molecular weight, concentration and salt forms. Aaps Pharmscitech. 2010;11(1):64–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Christie RJ, Matsumoto Y, Miyata K, Nomoto T, Fukushima S, Osada K, et al. Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection. ACS Nano. 2012;6(6):5174–89.

    Article  CAS  PubMed  Google Scholar 

  37. Abdelghany SM, Schmid D, Deacon J, Jaworski J, Fay F, McLaughlin KM, et al. Enhanced antitumor activity of the photosensitizer meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate through encapsulation in antibody-targeted chitosan/alginate nanoparticles. Biomacromolecules. 2013;14(2):302–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Zheng C, Zheng M, Gong P, Deng J, Yi H, Zhang P, et al. Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy. Biomaterials. 2013;34(13):3431–8.

    Article  CAS  PubMed  Google Scholar 

  39. Kim E, Yang J, Kim H-O, An Y, Lim E-K, Lee G, et al. Hyaluronic acid receptor-targetable imidazolized nanovectors for induction of gastric cancer cell death by RNA interference. Biomaterials. 2013;34(17):4327–38.

    Article  CAS  PubMed  Google Scholar 

  40. Lee SJ, Yhee JY, Kim SH, Kwon IC, Kim K. Biocompatible gelatin nanoparticles for tumor-targeted delivery of polymerized siRNA in tumor-bearing mice. J Control Release. 2013;172(1):358–66.

    Article  CAS  PubMed  Google Scholar 

  41. Yoon HY, Son S, Lee SJ, You DG, Yhee JY, Park JH, et al. Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA. Sci Rep. 2014;4.

    Google Scholar 

  42. Taratula O, Garbuzenko OB, Kirkpatrick P, Pandya I, Savla R, Pozharov VP, et al. Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery. J Control Release. 2009;140(3):284–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Agrawal A, Min D-H, Singh N, Zhu H, Birjiniuk A, Von Maltzahn G, et al. Functional delivery of siRNA in mice using dendriworms. ACS Nano. 2009;3(9):2495–504.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Liu X, Liu C, Laurini E, Posocco P, Pricl S, Qu F, et al. Efficient delivery of sticky siRNA and potent gene silencing in a prostate cancer model using a generation 5 triethanolamine-core PAMAM dendrimer. Mol Pharm. 2012;9(3):470–81.

    Article  CAS  PubMed  Google Scholar 

  45. Pérez-Martínez FC, Carrión B, Lucío MI, Rubio N, Herrero MA, Vázquez E, et al. Enhanced docetaxel-mediated cytotoxicity in human prostate cancer cells through knockdown of cofilin-1 by carbon nanohorn delivered siRNA. Biomaterials. 2012;33(32):8152–9.

    Article  PubMed  Google Scholar 

  46. Cho SK, Pedram A, Levin ER, Kwon YJ. Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD). Biomaterials. 2013;34(38):10228–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Khan OF, Zaia EW, Jhunjhunwala S, Xue W, Cai W, Yun DS, et al. Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature. Nano Lett. 2015.

    Google Scholar 

  48. Duncan R, Izzo L. Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev. 2005;57(15):2215–37.

    Article  CAS  PubMed  Google Scholar 

  49. Tomalia DA, Naylor AM, Goddard WA. Starburst dendrimers: molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter. Angewandte Chemie Int Ed English. 1990;29(2):138–75.

    Article  Google Scholar 

  50. Pirollo KF, Rait A, Zhou Q, Hwang SH, Dagata JA, Zon G, et al. Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system. Cancer Res. 2007;67(7):2938–43.

    Article  CAS  PubMed  Google Scholar 

  51. Peer D, Park EJ, Morishita Y, Carman CV, Shimaoka M. Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science. 2008;319(5863):627–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Yagi N, Manabe I, Tottori T, Ishihara A, Ogata F, Kim JH, et al. A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo. Cancer Res. 2009;69(16):6531–8.

    Article  CAS  PubMed  Google Scholar 

  53. Chen Y, Sen J, Bathula SR, Yang Q, Fittipaldi R, Huang L. Novel cationic lipid that delivers siRNA and enhances therapeutic effect in lung cancer cells. Mol Pharm. 2009;6(3):696–705.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Wang Y, Zhang L, Guo S, Hatefi A, Huang L. Incorporation of histone derived recombinant protein for enhanced disassembly of core-membrane structured liposomal nanoparticles for efficient siRNA delivery. J Control Release. 2013;172(1):179–89.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Deng ZJ, Morton SW, Ben-Akiva E, Dreaden EC, Shopsowitz KE, Hammond PT. Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and siRNA for potential triple-negative breast cancer treatment. ACS Nano. 2013;7(11):9571–84.

    Article  CAS  PubMed  Google Scholar 

  56. Resnier P, David S, Lautram N, Delcroix GJ-R, Clavreul A, Benoit J-P, et al. EGFR siRNA lipid nanocapsules efficiently transfect glioma cells in vitro. Int J Pharm. 2013;454(2):748–55.

    Article  CAS  PubMed  Google Scholar 

  57. Lee JB, Zhang K, Tam YYC, Tam YK, Belliveau NM, Sung VY, et al. Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo. Int J Cancer. 2012;131(5):E781–90.

    Article  CAS  PubMed  Google Scholar 

  58. Yang X-Z, Dou S, Wang Y-C, Long H-Y, Xiong M-H, Mao C-Q, et al. Single-step assembly of cationic lipid–polymer hybrid nanoparticles for systemic delivery of siRNA. ACS Nano. 2012;6(6):4955–65.

    Article  CAS  PubMed  Google Scholar 

  59. Hatakeyama H, Akita H, Ito E, Hayashi Y, Oishi M, Nagasaki Y, et al. Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid. Biomaterials. 2011;32(18):4306–16.

    Article  CAS  PubMed  Google Scholar 

  60. Li L, Wang R, Wilcox D, Zhao X, Song J, Lin X, et al. Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery. Gene Ther. 2012;19(7):775–80.

    Article  CAS  PubMed  Google Scholar 

  61. Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, et al. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat Biotechnol. 2013;31(7):653–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Liang C, Guo B, Wu H, Shao N, Li D, Liu J, et al. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat Med. 2015;21(3):288–94.

    Article  PubMed  Google Scholar 

  63. Wang M, Alberti K, Varone A, Pouli D, Georgakoudi I, Xu Q. Enhanced intracellular siRNA delivery using bioreducible lipid-like nanoparticles. Adv Healthcare Mater. 2014;3(9):1398–403.

    Article  CAS  Google Scholar 

  64. Brock A, Krause S, Li H, Kowalski M, Goldberg MS, Collins JJ, et al. Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice. Sci Transl Med. 2014;6(217):217ra2.

    Article  PubMed  Google Scholar 

  65. Whitehead KA, Dorkin JR, Vegas AJ, Chang PH, Veiseh O, Matthews J, et al. Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity. Nat Commun. 2014;5.

    Google Scholar 

  66. Goldberg MS, Xing D, Ren Y, Orsulic S, Bhatia SN, Sharp PA. Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Proc Natl Acad Sci. 2011;108(2):745–50.

    Article  CAS  PubMed  Google Scholar 

  67. Kim HJ, Takemoto H, Yi Y, Zheng M, Maeda Y, Chaya H, et al. Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles. ACS Nano. 2014;8(9):8979–91.

    Article  CAS  PubMed  Google Scholar 

  68. DeLong RK, Akhtar U, Sallee M, Parker B, Barber S, Zhang J, et al. Characterization and performance of nucleic acid nanoparticles combined with protamine and gold. Biomaterials. 2009;30(32):6451–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Chen AM, Taratula O, Wei D, Yen H-I, Thomas T, Thomas T, et al. Labile catalytic packaging of DNA/siRNA: control of gold nanoparticles “out” of DNA/siRNA complexes. ACS Nano. 2010;4(7):3679–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Huschka R, Barhoumi A, Liu Q, Roth JA, Ji L, Halas NJ. Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA. ACS Nano. 2012;6(9):7681–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Lin J, Huang Z, Wu H, Zhou W, Jin P, Wei P, et al. Inhibition of autophagy enhances the anticancer activity of silver nanoparticles. Autophagy. 2014;10(11):2006–20.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Laha D, Pramanik A, Maity J, Mukherjee A, Pramanik P, Laskar A, et al. Interplay between autophagy and apoptosis mediated by copper oxide nanoparticles in human breast cancer cells MCF7. Biochim Biophys Acta. 2014;1840(1):1–9.

    Article  CAS  PubMed  Google Scholar 

  73. Bae KH, Lee K, Kim C, Park TG. Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging. Biomaterials. 2011;32(1):176–84.

    Article  CAS  PubMed  Google Scholar 

  74. Yoo B, Ifediba MA, Ghosh S, Medarova Z, Moore A. Combination treatment with theranostic nanoparticles for glioblastoma sensitization to TMZ. Mol Imaging Biol. 2014;16(5):680–9.

    Article  PubMed  Google Scholar 

  75. Ghosh SK, Yigit MV, Uchida M, Ross AW, Barteneva N, Moore A, et al. Sequence-dependent combination therapy with doxorubicin and a survivin-specific small interfering RNA nanodrug demonstrates efficacy in models of adenocarcinoma. Int J Cancer. 2014;134(7):1758–66.

    Article  CAS  PubMed  Google Scholar 

  76. Derfus AM, Chen AA, Min D-H, Ruoslahti E, Bhatia SN. Targeted quantum dot conjugates for siRNA delivery. Bioconjug Chem. 2007;18(5):1391–6.

    Article  CAS  PubMed  Google Scholar 

  77. Yezhelyev MV, Qi L, O’Regan RM, Nie S, Gao X. Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging. J Am Chem Soc. 2008;130(28):9006–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Jung J, Solanki A, Memoli KA, Kamei K, Kim H, Drahl MA, et al. Selective inhibition of human brain tumor cells through multifunctional quantum-dot-based siRNA delivery. Angew Chem. 2010;122(1):107–11.

    Article  Google Scholar 

  79. Xia T, Kovochich M, Liong M, Meng H, Kabehie S, George S, et al. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano. 2009;3(10):3273–86.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Tanaka T, Mangala LS, Vivas-Mejia PE, Nieves-Alicea R, Mann AP, Mora E, et al. Sustained small interfering RNA delivery by mesoporous silicon particles. Cancer Res. 2010;70(9):3687–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Giger EV, Castagner B, Räikkönen J, Mönkkönen J, Leroux JC. siRNA transfection with calcium phosphate nanoparticles stabilized with PEGylated chelators. Adv Healthcare Mater. 2013;2(1):134–44.

    Article  CAS  Google Scholar 

  82. Tseng Y-C, Xu Z, Guley K, Yuan H, Huang L. Lipid–calcium phosphate nanoparticles for delivery to the lymphatic system and SPECT/CT imaging of lymph node metastases. Biomaterials. 2014;35(16):4688–98.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Xie Y, Qiao H, Su Z, Chen M, Ping Q, Sun M. PEGylated carboxymethyl chitosan/calcium phosphate hybrid anionic nanoparticles mediated hTERT siRNA delivery for anticancer therapy. Biomaterials. 2014;35(27):7978–91.

    Article  CAS  PubMed  Google Scholar 

  84. Parodi A, Haddix SG, Taghipour N, Scaria S, Taraballi F, Cevenini A, et al. Bromelain surface modification increases the diffusion of silica nanoparticles in the tumor extracellular matrix. ACS Nano. 2014;8(10):9874–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Boussif O, Lezoualc'h F, Zanta MA, Mergny MD, Scherman D, Demeneix B, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci. 1995;92(16):7297–301.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Jiang Y, Tang R, Duncan B, Jiang Z, Yan B, Mout R, et al. Direct cytosolic delivery of siRNA using nanoparticle-stabilized nanocapsules. Angew Chem Int Ed. 2015;54(2):506–10.

    CAS  Google Scholar 

  87. Kim JH, Noh YW, Heo MB, Cho MY, Lim YT. Multifunctional hybrid nanoconjugates for efficient in vivo delivery of immunomodulating oligonucleotides and enhanced antitumor immunity. Angewandte Chemie. 2012;124(38):9808–11.

    Article  Google Scholar 

  88. Tasciotti E, Liu X, Bhavane R, Plant K, Leonard AD, Price BK, et al. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nat Nanotechnol. 2008;3(3):151–7.

    Article  CAS  PubMed  Google Scholar 

  89. Bimbo LM, Sarparanta M, Mäkilä E, Laaksonen T, Laaksonen P, Salonen J, et al. Cellular interactions of surface modified nanoporous silicon particles. Nanoscale. 2012;4(10):3184–92.

    Article  CAS  PubMed  Google Scholar 

  90. Anglin EJ, Cheng L, Freeman WR, Sailor MJ. Porous silicon in drug delivery devices and materials. Adv Drug Deliv Rev. 2008;60(11):1266–77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  91. Wan Y, Apostolou S, Dronov R, Kuss B, Voelcker NH. Cancer-targeting siRNA delivery from porous silicon nanoparticles. Nanomedicine. 2014;9(15):2309–21.

    Article  CAS  PubMed  Google Scholar 

  92. Decuzzi P, Godin B, Tanaka T, Lee S-Y, Chiappini C, Liu X, et al. Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release. 2010;141(3):320–7.

    Article  CAS  PubMed  Google Scholar 

  93. Xu R, Huang Y, Mai J, Zhang G, Guo X, Xia X, et al. Multistage vectored siRNA targeting ataxia-telangiectasia mutated for breast cancer therapy. Small. 2013;9(9‐10):1799–808.

    Article  CAS  PubMed  Google Scholar 

  94. Shen J, Xu R, Mai J, Kim H-C, Guo X, Qin G, et al. High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics. ACS Nano. 2013;7(11):9867–80.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Molecular Imaging Laboratory, Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 13th Street, Boston, MA, 02129, USA

    Byunghee Yoo & Zdravka Medarova

Authors
  1. Byunghee Yoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zdravka Medarova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Byunghee Yoo or Zdravka Medarova .

Editor information

Editors and Affiliations

  1. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Jeff W.M. Bulte

  2. Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Michel M.J. Modo

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Yoo, B., Medarova, Z. (2017). Nanoformulations for Pharmacological siRNA Delivery in Cancer. In: Bulte, J., Modo, M. (eds) Design and Applications of Nanoparticles in Biomedical Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-42169-8_8

Download citation

Publish with us

Policies and ethics

Search

Navigation