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Light-Based Procedures in Pediatric Dermatology

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Therapy in Pediatric Dermatology
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Abstract

Light- and laser-based therapies are valuable and safe therapeutic options in the pediatric population. Laser (light amplification by stimulated emission of radiation) by definition delivers coherent monochromatic light to a concentrated area of tissue. Light therapy, on the other hand, employs a variety of lights and mechanisms. This chapter will focus on available light-based therapies used for the management of common and recalcitrant pediatric dermatologic conditions. This includes light-emitting diodes, intense pulsed light, photodynamic therapy, ultraviolet phototherapy and extracorporeal photopheresis.

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References

  1. Ennever JF, McDonagh AF, Speck WT. Phototherapy for neonatal jaundice: optical wavelengths of light. J Pediatr. 1983;103(2):295–9.

    Article  CAS  PubMed  Google Scholar 

  2. American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114(1):297–316.

    Article  Google Scholar 

  3. Kong YL, Tey HL. Treatment of acne vulgaris during pregnancy and lactation. Drugs. 2013;73(8):779–87.

    Article  CAS  PubMed  Google Scholar 

  4. Ammad S, Gonzales M, Edwards C, Finlay AY, Mills C. An assessment of the efficacy of blue light phototherapy in the treatment of acne vulgaris. J Cosmet Dermatol. 2008;7(3):180–8.

    Article  PubMed  Google Scholar 

  5. Kwon HH, Lee JB, Yoon JY, Park SY, Ryu HH, Park BM, et al. The clinical and histological effect of home-use, combination blue-red LED phototherapy for mild to moderate acne vulgaris in Korean patients: a double-blind, randomized controlled trial. Br J Dermatol. 2013;168(5):1088–94.

    Article  CAS  PubMed  Google Scholar 

  6. Taub AF. Photodynamic therapy for the treatment of acne: a pilot study. J Drugs Dermatol. 2004;3(6 Suppl):S10–4.

    PubMed  Google Scholar 

  7. Kim RH, Armstrong AW. Current state of acne treatment: highlighting lasers, photodynamic therapy, and chemical peels. Dermatol Online J. 2011;17(3):2.

    PubMed  Google Scholar 

  8. Rojanamatin J, Choawawanich P. Treatment of inflammatory facial acne vulgaris with intense pulsed light and short contact of topical 5-aminolevulinic acid: a pilot study. Dermatol Surg. 2006;32(8):991–6.

    CAS  PubMed  Google Scholar 

  9. Hongcharu W, Taylor CR, Chang Y, Aghassi D, Suthamjariya K, Anderson RR. Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Invest Dermatol. 2000;115(2):183–92.

    Article  CAS  PubMed  Google Scholar 

  10. Schweiger ES, Riddle CC, Aires DJ. Treatment of hidradenitis suppurativa by photodynamic therapy with aminolevulinic acid: preliminary results. J Drugs Dermatol. 2011;10(4):381–6.

    CAS  PubMed  Google Scholar 

  11. Stender IM, Na R, Fogh H, Gluud C, Wulf HC. Photodynamic therapy with 5-aminolaevulinic acid or placebo for recalcitrant foot and hand warts: randomized double-blind trial. Lancet. 2000;355(9208):963–6.

    Article  CAS  PubMed  Google Scholar 

  12. Schroeter CA, Pleunis J, van Nispen tot Pannerden C, Reineke T, Neumann HA. Photodynamic therapy: new treatment for therapy-resistant plantar warts. Dermatol Surg. 2005;31(1):71–5.

    Article  CAS  PubMed  Google Scholar 

  13. Stender IM, Lock-Andersen J, Wulf HC. Recalcitrant hand and foot warts successfully treated with photodynamic therapy with topical 5-aminolaevulinic acid: a pilot study. Clin Exp Dermatol. 1999;24(3):154–9.

    Article  CAS  PubMed  Google Scholar 

  14. Schroeter CA, Kaas L, Waterval JJ, Bos PM, Neumann HA. Successful treatment of periungual warts using photodynamic therapy: a pilot study. J Eur Acad Dermatol Venereol. 2007;21(9):1170–4.

    CAS  PubMed  Google Scholar 

  15. Caucanas M, Gillard P, Vanhooteghem O. Efficiency of photodynamic therapy in the treatment of diffuse facial viral warts in an immunosuppressed patient: towards a gold standard? Case Rep Dermatol. 2010;2(3):207–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Lu YG, Wu JJ, He Y, Yang HZ, Yang YD. Efficacy of topical aminolevulinic acid photodynamic therapy for the treatment of verruca planae. Photomed Laser Surg. 2010;28(4):561–3.

    Article  PubMed  Google Scholar 

  17. Zandi S, Kalia S, Lui H. UVA1 Phototherapy: a concise and practical review. Skin Therapy Lett. 2012;17(1):1–4.

    PubMed  Google Scholar 

  18. Fett NM. Morphea: evidence-based recommendations for treatment. Indian J Dermatol Venereol Leprol. 2012;78(2):135–41.

    Article  PubMed  Google Scholar 

  19. Andres C, Kollmar A, Mempel M, Hein R, Ring J, Eberlein B. Successful ultraviolet A1 phototherapy in the treatment of localized scleroderma: a retrospective and prospective study. Br J Dermatol. 2010;162(2):445–7.

    Article  CAS  PubMed  Google Scholar 

  20. Kerscher M, Volkenandt M, Gruss C, Reuther T, von Kobyletzki G, Freitag M, et al. Low-dose UVA phototherapy for treatment of localized scleroderma. J Am Acad Dermatol. 1998;38(1):21–6.

    Article  CAS  PubMed  Google Scholar 

  21. Kanekura T, Fukumaru S, Matsushita S, Terasaki K, Mizoguchi S, Kanzaki T. Successful treatment of scleroderma with PUVA therapy. J Dermatol. 1996;23(7):455–9.

    Article  CAS  PubMed  Google Scholar 

  22. Schlaak M, Schwind S, Wetzig T. UVA (UVA-1) therapy for the treatment of acute GVHD of the skin. Bone Marrow Transplant. 2010;45:1741–8.

    Article  CAS  PubMed  Google Scholar 

  23. Yones SS, Palmer RA, Garibaldinos TT, Hawk JL. Randomized double-blind trial of the treatment of chronic plaque psoriasis: efficacy of psoralen-UV-A therapy vs narrowband UV-B therapy. Arch Dermatol. 2006;142(7):836–42.

    Article  CAS  PubMed  Google Scholar 

  24. Abeck D, Schmidt T, Fesq H, Strom K, Mempel M, Brockow K, et al. Long-term efficacy of medium-dose UVA1 phototherapy in atopic dermatitis. J Am Acad Dermatol. 2000;42(2 Pt 1):254–7.

    Article  CAS  PubMed  Google Scholar 

  25. Macias VC, Marques-Pinto G, Cardoso J. Phototherapy for pityriasis lichenoides: our experience. Cutan Ocul Toxicol. 2013;32(2):124–7.

    Article  PubMed  Google Scholar 

  26. Farnaghi F, Seirafi H, Ehsani AH, Agdari ME, Noormohammadpour P. Comparison of the therapeutic effects of narrow band UVB vs. PUVA in patients with pityriasis lichenoides. J Eur Acad Dermatol Venereol. 2011;25(8):913–6.

    Article  CAS  PubMed  Google Scholar 

  27. Powell FC, Muller SA. Psoralens and ultraviolet A therapy of pityriasis lichenoides. J Am Acad Dermatol. 1984;10(1):59–64.

    Article  CAS  PubMed  Google Scholar 

  28. Lassus A, Kianto U, Johansson E, Juvakoski T. PUVA treatment for alopecia areata. Dermatologica. 1980;161(5):298–304.

    Article  CAS  PubMed  Google Scholar 

  29. van der Schaar WW, Sillevis Smith JH. An evaluation of PUVA-therapy for alopecia areata. Dermatologica. 1984;168(5):250–2.

    Article  PubMed  Google Scholar 

  30. Dawe RS, Ferguson J. Prolonged benefit following ultraviolet A phototherapy for solar urticaria. Br J Dermatol. 1997;137(1):144–8.

    Article  CAS  PubMed  Google Scholar 

  31. Beissert S, Stander H, Schwarz T. UVA rush hardening for the treatment of solar urticaria. J Am Acad Dermatol. 2000;42(6):1030–2.

    Article  CAS  PubMed  Google Scholar 

  32. Smith ML, Orton PW, Chu H, Weston WL. Photochemotherapy of dominant, diffuse, cutaneous mastocytosis. Pediatr Dermatol. 1990;7(4):251–5.

    Article  CAS  PubMed  Google Scholar 

  33. Mackey S, Pride HB, Tyler WB. Diffuse cutaneous mastocytosis. Treatment with oral psoralen plus UV-A. Arch Dermatol. 1996;132(12):1429–30.

    Article  CAS  PubMed  Google Scholar 

  34. Hann SK, Cho MY, Im S, Park YK. Treatment of vitiligo with oral 5-methoxypsoralen. J Dermatol. 1991;18(6):324–9.

    Article  CAS  PubMed  Google Scholar 

  35. Parrish JA, Fitzpatrick TB, Shea C, Pathak MA. Photochemotherapy of vitiligo. Use of orally administered psoralens and a high-intensity long-wave ultraviolet light system. Arch Dermatol. 1976;112(11):1531–4.

    Article  CAS  PubMed  Google Scholar 

  36. Pathak MA, Mosher DB, Fitzpatrick TB. Safety and therapeutic effectiveness of 8-methoxypsoralen,4,5,8-trimethylpsoralen, and psoralen in vitiligo. Natl Cancer Inst Monogr. 1984;66:165–73.

    CAS  PubMed  Google Scholar 

  37. Pavlotsky F, Hodak E, Ben Amitay D, Barzilai A. Role of bath psoralen plus ultraviolet A in early-stage mycosis fungoides. J Am Acad Dermatol. 2014;71(3):536–41.

    Article  CAS  PubMed  Google Scholar 

  38. Laws PM, Shear NH, Pope E. Childhood mycosis fungoides: experience of 28 patients and response to phototherapy. Pediatr Dermatol. 2014;31(4):459–64.

    Article  PubMed  Google Scholar 

  39. Baron ED, Stevens SR. Phototherapy for cutaneous T-cell lymphoma. Dermatol Ther. 2003;16(4):303–10.

    Article  PubMed  Google Scholar 

  40. Valkova S, Velkova A. UVA/UVB phototherapy for atopic dermatitis revisited. J Dermatolog Treat. 2004;15(4):239–44.

    Article  CAS  PubMed  Google Scholar 

  41. Jekler J, Larko O. UVB phototherapy of atopic dermatitis. Br J Dermatol. 1988;119(6):697–705.

    Article  CAS  PubMed  Google Scholar 

  42. Kleinpenning MM, Smits T, Boezeman J, van de Kerkhof PC, Evers AW, Gerritsen MJ. Narrowband ultraviolet B therapy in psoriasis: randomized double-blind comparison of high-dose and low dose irradiation regimens. Br J Dermatol. 2009;161(6):1351–6.

    Article  CAS  PubMed  Google Scholar 

  43. Yones SS, Palmer RA, Garibaldinos TM, Hawk JL. Randomized double-blind trial of treatment of vitiligo: efficacy of psoralen-UV-A therapy vs narrowband- UV-B therapy. Arch Dermatol. 2007;143(5):578–84.

    Article  CAS  PubMed  Google Scholar 

  44. Aydogan K, Saricaoglu H, Turan H. Narrowband UVB (311 nm, TL01) phototherapy for pityriasis lichenoides. Photodermatol Photoimmunol Photomed. 2008;24(3):128–33.

    Article  PubMed  Google Scholar 

  45. Chiriac A, Brzezinski P, Pinteala T. Successful treatment of morphea with narrowband UVB (310–315 nm)-case report. Austin J Dermatol. 2014;1(4):1018.

    Google Scholar 

  46. Al-Mutairi N. 308-nm excimer laser for the treatment of alopecia areata in children. Pediatr Dermatol. 2009;26(5):547–50.

    Article  PubMed  Google Scholar 

  47. Gathers RC, Scherschun L, Malick F, Fivenson DP, Lim HW. Narrowband UVB phototherapy for early-stage mycosis fungoides. J Am Acad Dermatol. 2002;47(2):191.

    Article  PubMed  Google Scholar 

  48. Seckin D, Demircay Z, Akin O. Generalized pruritus treated with narrowband UVB. Int J Dermatol. 2007;46(4):367–70.

    Article  PubMed  Google Scholar 

  49. Tamagawa-Mineoka R, Katoh N, Ueda E, Kishimoto S. Narrow-band ultraviolet B phototherapy in patients with recalcitrant nodular prurigo. J Dermatol. 2007;34(10):691–5.

    Article  CAS  PubMed  Google Scholar 

  50. Gupta G, Man I, Kemmett D. Hydroa vacciniforme: a clinical and follow-up study of 17 cases. J Am Acad Dermatol. 2000;42(2 Pt 1):208–13.

    Article  CAS  PubMed  Google Scholar 

  51. Collins P, Ferguson J. Narrow-band UVB (TL-01) phototherapy: an effective preventative treatment for the photodermatoses. Br J Dermatol. 1995;132(6):956–63.

    Article  CAS  PubMed  Google Scholar 

  52. Inui S, Nishida Y, Itami S, Katayama I. Disseminated granuloma annulare responsive to narrowband ultraviolet B therapy. J Am Acad Dermatol. 2005;53(3):532–3.

    Article  Google Scholar 

  53. Kerker BJ, Huang CP, Morison WL. Photochemotherapy of generalized granuloma annulare. Arch Dermatol. 1990;126(3):359–61.

    Article  CAS  PubMed  Google Scholar 

  54. Iraji F, Faghihi G, Asilian A, Siadat AH, Larijani FT, Akbari M. Comparison of the narrow band UVB versus systemic corticosteroids in the treatment of lichen planus: a randomized clinical trial. J Res Med Sci. 2011;16(12):1578–82.

    PubMed  PubMed Central  Google Scholar 

  55. Jairath V, Mohan M, Jindal N, Gogna P, Syrty C, Monnappa PM, et al. Narrowband UVB phototherapy in pityriasis rosea. Indian Dermatol Online J. 2015;6(5):326–9.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Glatz M, Hofbauer GF. Phototoxic and photoallergic cutaneous drug reactions. Chem Immunol Allergy. 2012;97:167–79.

    Article  CAS  PubMed  Google Scholar 

  57. Knobler RM, Graninger W, Graninger W, Lindmaier A, Trautinger F, Smolen JS. Extracorporeal photochemotherapy for the treatment of systemic lupus erythematosus. A pilot study. Arthritis Rheum. 1992;35(3):319–24.

    Article  CAS  PubMed  Google Scholar 

  58. Guyot AD, Farhi D, Ingen-Housz-Oro S, Bussel A, Parquet N, Rabian C, et al. Treatment of refractory erosive oral lichen planus with extracorporeal photochemotherapy: 12 cases. Br J Dermatol. 2007;156(3):553–6.

    Article  CAS  PubMed  Google Scholar 

  59. Bisaccia E, Palangio M, Gonzalez J. Long-term extracorporeal photochemotherapy in a pediatric patient with refractory sclerodermatous chronic graft-versus-host disease. Transfus Apher Sci. 2011;45(2):187–90.

    Article  PubMed  Google Scholar 

  60. Zic J, Arzubiaga C, Salhany KE, Parker RA, Wilson D, Stricklin GP, et al. Extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma. J Am Acad Dermatol. 1992;27(5 Pt 1):729–36.

    Article  CAS  PubMed  Google Scholar 

  61. Heald P, Rook A, Perez M, Wintroub B, Knobler R, Jegasothy B, et al. Treatment of erythrodermic cutaneous T-cell lymphoma with extracorporeal photochemotherapy. J Am Acad Dermatol. 1992;27(3):427–33.

    Article  CAS  PubMed  Google Scholar 

  62. Papp G, Barath S, Szegedi A, Szodoray P, Zeher M. The effects of extracorporeal photochemotherapy on T cell activation and regulatory mechanisms in patients with systemic sclerosis. Clin Rheumatol. 2012;31(9):1293–9.

    Article  PubMed  Google Scholar 

  63. Liszewski W, Omland SH, Gniadecki R. The successful use of extracorporeal photopheresis in a 12-year-old patient with refractory epidermolysis bullosa acquisita. Pediatr Dermatol. 2015;32(2):e60–1.

    Article  PubMed  Google Scholar 

  64. Gordon KB, Chan LS, Woodley DT. Treatment of refractory epidermolysis bullosa acquisita with extracorporeal photochemotherapy. Br J Dermatol. 1997;136(3):415–20.

    Article  CAS  PubMed  Google Scholar 

  65. Miller JL, Stricklin GP, Fine JD, King LE, Arzubiaga MC, Ellis DL. Remission of severe epidermolysis bullosa acquisita induced by extracorporeal photochemotherapy. Br J Dermatol. 1995;133(3):467–71.

    Article  CAS  PubMed  Google Scholar 

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Benjamin, L.T. (2017). Light-Based Procedures in Pediatric Dermatology. In: Teng, J., Marqueling, A., Benjamin, L. (eds) Therapy in Pediatric Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-43630-2_27

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  • DOI: https://doi.org/10.1007/978-3-319-43630-2_27

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