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Autoimmunity

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Neuroimmune Pharmacology

Abstract

The dogma of the immunological privilege of central nervous system (CNS) has been increasingly challenged by compelling evidence showing reciprocal communication pathways between the CNS and the immune system. Brain antigens may drain to the cervical lymph nodes and induce induce antibody production and T lymphocyte homing to the CNS. It is now clear that, besides classical autoimmune diseases of the CNS such as multiple scleosis, many CNS diseases which were previously considered as purely neurodegenerative include inflammatory and autoimmune components. The present chapter critically summarizes available evidence concerning autoimmune neuroinflammation in classical neurodegenerative disease such as Alzheimer’s disease and Parkinson’s disease, and in amiotrophic lateral sclerosis. Attention will be paid also to the possible autoimmune basis of some forms of epilepsies, and the possibile neuroprotective role of autoimmune T lymphocytes (neuroprotective autoimmunity) will be finally discussed.

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  1. Center for Research in Medical Pharmacology, University of Insubria, Via Ottorino Rossi n. 9, Varese, 21100, Italy

    Marco Cosentino, Natasa Kustrimovic & Franca Marino

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  1. Marco Cosentino
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  2. Natasa Kustrimovic
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Correspondence to Marco Cosentino .

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  1. Departments of Pharmacology and Experimental Therapeutics and Neurology, Boston University School of Medicine, Boston, Massachusetts, USA

    Tsuneya Ikezu

  2. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Nebraska Medical Center, Omaha, Nebraska, USA

    Howard E. Gendelman

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Cosentino, M., Kustrimovic, N., Marino, F. (2017). Autoimmunity. In: Ikezu, T., Gendelman, H. (eds) Neuroimmune Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-44022-4_26

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