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Harnessing the Power of the Human Immune System via Multi-omic Immune Profiling in Stroke Treatment and Recovery

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Neuroprotective Therapy for Stroke and Ischemic Disease

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Precision health is an unrealized opportunity in the practice and care of stroke patients. To achieve truly person-centered care as the Precision Medicine Initiative (PMI) outlines, a new approach to stroke research is necessary. Multi-omic profiling of the immune system response to human stroke provides a significant advantage over single system and/or multibiomarker analyses. By combining powerful ‘omic’ technologies with machine learning and pattern recognition for interpretation of this multi-omic data, we are better able to understand the complexity of stroke physiology. These measurements allow for new methods in the diagnosis, treatment stratification, and design of personalized approaches to stroke recovery. The foundation by which these novel approaches can be utilized to understand human stroke complexity and translated into programs of research and clinical practice paradigms is being created, and will ultimately change the way we diagnosis and treat stroke patients. This review will briefly outline current approaches and how to leverage these discoveries to achieve person-centered stroke care.

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Authors and Affiliations

  1. CereDx Inc., Eight Medical Center Drive, Morgantown, WV, 26506, USA

    Taura L. Barr Ph.D., R.N., F.A.H.A., V. Gionis & R. Giersch

Authors
  1. Taura L. Barr Ph.D., R.N., F.A.H.A.
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  2. V. Gionis
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  3. R. Giersch
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Corresponding author

Correspondence to Taura L. Barr Ph.D., R.N., F.A.H.A. .

Editor information

Editors and Affiliations

  1. Department of Neurology and Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA

    Paul A. Lapchak

  2. Loma Linda University School of Medicine, Loma Linda, California, USA

    John H. Zhang

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Barr, T.L., Gionis, V., Giersch, R. (2017). Harnessing the Power of the Human Immune System via Multi-omic Immune Profiling in Stroke Treatment and Recovery. In: Lapchak, P., Zhang, J. (eds) Neuroprotective Therapy for Stroke and Ischemic Disease. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-45345-3_11

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  • DOI: https://doi.org/10.1007/978-3-319-45345-3_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-45344-6

  • Online ISBN: 978-3-319-45345-3

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