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The Induction of Drosophila Heat Shock Proteins by Plants That Can Extend Fly Lifespan

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Heat Shock Proteins and Plants

Part of the book series: Heat Shock Proteins ((HESP,volume 10))

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Abstract

The occurrence of most non-infectious diseases increases as we get older. There is now a growing research effort to understand aging, and try to slow it in order to treat a broad range of diseases. The underlying molecular mechanisms of aging are not clear, and there are many theories, each with varying degrees of support. A hallmark of aging is a decreased resistance to environmental stresses such as heat, and the lifespan of many organisms is inversely related to body temperature. One strategy for slowing the aging process is to screen for drugs and botanical extracts that can extend lifespan in model organisms such as the fruit fly, Drosophila melanogaster. Several botanical extracts have been recently identified to increase lifespan in flies. Surprisingly, there is no overall correlation between increased lifespan and an increased tolerance to heat. In one case, an extract that increased fly lifespan had a marked decreased in heat tolerance and heat shock protein expression. These results parallel those of the direct study of HSP expression and lifespan in fruit flies. In summary, there is no clear relationship between the induction of HSPs and extension of lifespan in fruit flies through the use of botanical extracts.

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Abbreviations

DR:

dietary restriction

HSF:

heat shock factor

HSP:

heat shock protein

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Acknowledgments

I would like to thank Sally T. Pham and Benjamin V. Nguyen for the critical reading of this manuscript and providing helpful comments.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of California, 146 Bison Modular, Building 515, Irvine, CA, 92697, USA

    Samuel E. Schriner

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  1. Samuel E. Schriner
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Correspondence to Samuel E. Schriner .

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Editors and Affiliations

  1. Department of Neuroscience, University of Dammam, Damman, Saudi Arabia

    Alexzander A. A. Asea

  2. Division of Molecular and Cellular Biology Department of Radiation Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

    Punit Kaur

  3. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Stuart K. Calderwood

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Schriner, S.E. (2016). The Induction of Drosophila Heat Shock Proteins by Plants That Can Extend Fly Lifespan. In: Asea, A., Kaur, P., Calderwood, S. (eds) Heat Shock Proteins and Plants. Heat Shock Proteins, vol 10. Springer, Cham. https://doi.org/10.1007/978-3-319-46340-7_12

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