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Progress of Controlled Drug Delivery Systems in Topical Ophthalmology: Focus on Nano and Micro Drug Carriers

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Ocular Drug Delivery: Advances, Challenges and Applications

Abstract

Corneal and conjunctival epithelia, along with the tear film, serve as biological barriers to protect the eye from the entrance of potentially harmful substances. These barriers create constraint effective drug medication of ocular diseases with topical ocular formulations. Designing an effective therapy for ocular diseases, especially for the anterior segment, has been considered a challenging task. Nano-drug carriers giving us an array of hope for ocular drug therapy, owing to its potential to improve the ocular retention, controlled release, trans-corneal permeation and thus intra-ocular drug availability. Nanotechnology-based formulation design is important in ocular pharmaceuticals yet knowledge of anatomy and physiology of eyes are critical along with the understanding of nanoparticles design. Here, we discussed the ocular transport of topically applied drug, different barriers in its path and how the nanoparticles as drug carriers can improve the drug delivery to the eyes.

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Authors and Affiliations

  1. Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard University, New Delhi, 110062, India

    Ameeduzzafar Zafar

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, 229010, UP, India

    Javed Ahmad

  3. Department of Pharmaceutical Sciences, School of Pharmacy, Union University, Jackson, TN, USA

    Richard T. Addo

  4. LE STUDIUM® Loire Valley Institute for Advanced Studies, Centre-Val de Loire region, Orléans, France

    Sohail Akhter

  5. Nucleic Acids Transfer by Non-Viral Methods, Centre de Biophysique Moléculaire, CNRS, UPR4301, Orléans, France

    Sohail Akhter

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  1. Ameeduzzafar Zafar
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  2. Javed Ahmad
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  4. Sohail Akhter
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    Richard T. Addo

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Zafar, A., Ahmad, J., Addo, R.T., Akhter, S. (2016). Progress of Controlled Drug Delivery Systems in Topical Ophthalmology: Focus on Nano and Micro Drug Carriers. In: Addo, R. (eds) Ocular Drug Delivery: Advances, Challenges and Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-47691-9_9

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