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Neuropilin-Dependent Signaling and Neuropilin-Independent Signaling of the Guidance Molecule Sema3E

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The Neuropilins: Role and Function in Health and Disease

Abstract

Neuropilins are receptors for all but one secreted (class 3) Semaphorins. The exception is Sema3E that directly binds and activates the Plexin-D1 receptor to induce cell repulsion. In this chapter, we review works that identified an unexpected role of Neuropilin-1 as a gating switch in Sema3E/Plexin-D1 signaling, that converts repulsion into attraction, and discuss the implications of this finding for brain wiring.

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Acknowledgments

This work was supported by the Centre National de la Recherche Scientifique (CNRS), by Aix-Marseille Université, and by grants from the Agence Nationale de la Recherche (ANR-06-JCJC-0094-01, ANR-10-BLAN-1412, ANR-12-BSV4-0012-01), Fédération pour la Recherche sur le Cerveau, Fondation ARC, Institut National du Cancer (2011-139), Association Française contre les Myopathies, Fondation NRJ Institut de France, Fondation pour la Recherche Médicale (DEQ20150331728), and Institut Universitaire de France.

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  1. Aix-Marseille Université, CNRS, IBDM UMR 7288, 13288, Marseille, France

    Fanny Mann & Sophie Chauvet

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  1. Fanny Mann
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  2. Sophie Chauvet
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Correspondence to Fanny Mann .

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Editors and Affiliations

  1. Department Anatomy and Cell Biology, Israel Institute of Technology Technion, Haifa, Israel

    Gera Neufeld

  2. Department Anatomy and Cell Biology, Israel Institute of Technology Technion, Haifa, Israel

    Ofra Kessler

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Mann, F., Chauvet, S. (2017). Neuropilin-Dependent Signaling and Neuropilin-Independent Signaling of the Guidance Molecule Sema3E. In: Neufeld, G., Kessler, O. (eds) The Neuropilins: Role and Function in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-48824-0_5

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