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Roles of Grp78 in Female Mammalian Reproduction

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The Role of Heat Shock Proteins in Reproductive System Development and Function

Part of the book series: Advances in Anatomy, Embryology and Cell Biology ((ADVSANAT,volume 222))

Abstract

The glucose-regulated protein (GRP78) also referred to as immunoglobulin heavy chain binding protein (Bip) is one of the best characterized endoplasmic reticulum (ER) chaperone proteins, which belongs to the heat-shock protein (HSP) family. GRP78 as a central regulator of ER stress (ERS) plays many important roles in cell survival and apoptosis through controlling the activation of transmembrane ERS sensors: PKR-like ER-associated kinase (PERK), inositol requiring kinase 1 (IRE1), and activating transcription factor 6 (ATF6). Many studies have reported that GRP78 is involved in the physiological and pathological process in female reproduction, including follicular development, corpus luteum (CL), oviduct, uterus, embryo, preimplantation development, implantation/decidualization, and the placenta. The present review summarizes the biological or pathological roles and signaling mechanisms of GRP78 during the reproductive processes. Further study on the functions and mechanisms of GRP78 may provide new insight into mammalian reproduction, which not only enhance the understanding of the physiological roles but also support therapy target against infertility.

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Abbreviations

ATF6:

Activating transcription factor 6

Bip:

Immunoglobulin heavy chain binding protein

CHOP:

C/EBP-homologous protein/DNA damage-inducible transcript 3

CL:

Corpus luteum

eIF2α:

Eukaryotic translation initiation factor 2α

ER:

Endoplasmic reticulum

FSH:

Follicle stimulating hormone

GnRH:

Gonadotropin-releasing hormone

GRP78:

Glucose-regulated protein

HSP:

heat-shock protein

IRE1:

inositol requiring kinase 1

JNK:

c-Jun N-terminal kinase

LH:

Luteinizing hormone

PERK:

PKR-like ER-associated kinase

UPR:

Unfolded protein response

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 31671555; No 31300958) and Beijing Natural Science Foundation (No.5142003). And this project was also supported by Scientific Research Program of Beijing Municipal Commission of Education (KM201610028011). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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  1. College of Life Science, Capital Normal University, Beijing, 100048, PR China

    Cheng Zhang

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  1. Dept. of Veterinary Biomed. Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Daniel J. MacPhee

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Zhang, C. (2017). Roles of Grp78 in Female Mammalian Reproduction. In: MacPhee, D. (eds) The Role of Heat Shock Proteins in Reproductive System Development and Function. Advances in Anatomy, Embryology and Cell Biology, vol 222. Springer, Cham. https://doi.org/10.1007/978-3-319-51409-3_7

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