Abstract
The greatest burden of disease in Sub-Saharan Africa (SSA) is from infectious diseases. The incidence of all cancers is however rising. A complex web of poverty, ignorance, inadequate diagnostic and treatment facilities has made cancer outcomes worse in SSA in comparison with other world regions. This chapter provides an overview of cancer burden in SSA using data from cancer epidemiology databases and peer-reviewed publications. Age-standardized Cancer Incidences in SSA were obtained from the International Agency for Research in Cancer (IARC) publication – ‘Cancer incidences in five continents’. Recent cancer estimates were from GLOBOCAN 2008 (Ferlay et al. 2010) and GLOBOCAN 2012 (Ferlay et al. 2013). Cancer mortality was from WHO Mortality Database. The five commonest cancers in males in SSA in (Ferlay et al. 2013) (age-standardised incidence rate per 100,000 population) were: prostate cancer (27.9), liver cancer (10.2), Kaposi sarcoma (7.2), oesophageal cancer (6.8) and colorectal cancer (6.4). In females, ASIR per 100,000 for the commonest cancers were: cervix uteri cancer (34.8), breast cancer (33.8), liver cancer (5.4), colorectal cancer (5.4), ovarian (4.6). There were regional variations observed in cancer incidence in SSA. Tragically, survival from cancer in SSA was significantly worse than the rest of the world regions. Sub-Saharan Africa had disproportionately higher mortality rates from cancers compared to other world regions. The changes in population dynamics, lifestyles and diet across Africa, and the increasing role of viruses have coincided with the increasing cancer incidence. There is an urgent need for investment in cancer diagnosis and treatment to stem the current tide.
Many people feel cancer is a death sentence. Family feel it; friends, colleagues, they begin to look at you as if you are a ghost once there is a rumour you have cancer. No, cancer is not a death sentence, It is curable, I have undergone the treatment
Nobel Laureate, Wole Soyinka speaking on his experience following successful treatment for prostate cancer on 25th November 2014
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References
Abdel-Wahab M, Bourque J-M, Pynda Y, Iżewska J, der Merwe DV, Zubizarreta E, Rosenblatt E. Status of radiotherapy resources in Africa: an International Atomic Energy Agency analysis. Lancet Oncol. 2013;14:e168–75.
Adesina A, Chumba D, Nelson AM, et al. Improvement of pathology in sub-Saharan Africa. Lancet Oncol. 2013;14:e152–7.
Beasley RP, Hwang LY. Hepatocellular carcinoma and hepatitis B virus. Semin Liver Dis. 1984;4:113–21.
Bray F, Jemal A, Grey N, Ferlay J, Forman D. Global cancer transitions according to the human development index (2008–2030): a population-based study. Lancet Oncol. 2012;13:790–801.
Center M, Siegel R, Jemal A. Cancer in Africa. Am Cancer Soc. 2011:1–20.
Dhir AA, Sawant SP. Infections and cancers. Mumbai: Tata Memorial Hospital; 2012. ISBN:978-93-80251-16-5.
Ezzati M, Lopez AD. Regional, disease specific patterns of smoking-attributable mortality in 2000. Tob Control. 2004;13:388–95.
Ferlay J, Shin HR, Bray F, Forman D, Mathers CD, Parkin D. GLOBOCAN 2008, cancer incidence and mortality worldwide: IARC Cancer-Base No.10 [Internet]. Lyon: International Agency for Research on Cancer; 2010. http://globocan.iarc.fr. Accessed 19 Apr 2016.
Ferlay J, Forman D, Mathers CD, Bray F. Breast and cervical cancer in 187 countries between 1980 and 2010. Lancet. 2012;379(9824):1390–1.
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr. Accessed 19 Apr 2016.
Ganem D. KSHV infection and the pathogenesis of Kaposi’s sarcoma. Annu Rev Pathol. 2006;1:273–96.
Gichangi P, De Vuyst H, Estambale B, Rogo K, Bwayo J, Temmerman M. HIV and cervical cancer in Kenya. Int J Gynecol Obstet. 2002;76(1):55–63.
Graham A, et al. Estimating the incidence of colorectal cancer in sub-Saharan Africa: A systematic analysis. J Glob Health. 2012;2(2):020404.
Horner MJ, Ries LAG, Krapcho M, et al., editors. SEER cancer statistics review, 1975–2006. Bethesda: National Cancer Institute; 2009.
International Atomic Energy Agency. Programme of action for cancer therapy. Report by the Director General 2004; 74.
Irabor D, Adedeji OA. Colorectal cancer in Nigeria: 40 years on. A review. Eur J Cancer Care. 2009;18:110–5.
Jedy-Agba EE, Oga EA, Odutola M, Abdullahi YM, Popoola A, Achara P, Afolayan E, Banjo AA, Ekanem IO, Erinomo O, Ezeome E, Igbinoba F, Obiorah C, Ogunbiyi O, Omonisi A, Osime C, Ukah C, Osinubi P, Hassan R, Blattner W, Dakum P, Adebamowo CA. Developing national cancer registration in developing countries – case study of the Nigerian National System of Cancer Registries. Front Public Health. 2015;3:186.
Kachala R. Systematic review: epidemiology of oesophageal cancer in sub-Saharan Africa. Malawi Med J. 2010;22:65–70. Lancet Oncol 2013;14:e142–51.
Morhason-Bello IO, Odedina F, Rebbeck TR, Harford J, Dangou J-M, Denny L, Adewole IF. Challenges and opportunities in cancer control in Africa: a perspective from the African organisation for research and training in cancer. Lancet Oncol. 2013;14:e142–51.
Odigie VI, Tanaka R, Yusufu LM, et al. Psychosocial effects of mastectomy on married African women in northwestern Nigeria. Psychooncology. 2010;19:893–7.
Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006;118:3030–44.
Parkin DM. The role of cancer registries in cancer control. Int J Clin Oncol. 2008;13(2):102–11. doi:10.1007/s10147-008-0762-6.
Peter Kingham T, Alatise OI, Vanderpuye V, Casper C, Abantanga FA, Kamara TB, Olopade OI, Habeebu M, Abdulkareem FB, Denny L. Treatment of cancer in sub-Saharan Africa. Lancet Oncol. 2013;14:e158–67.
Sankaranarayanan R, Swaminathan R, Brenner H, et al. Cancer survival in Africa, Asia, and central America: a population-based study. Lancet Oncol. 2010;11:165–73.
Thomas DL, Astemborski J, Rai RM, Anania FA, Schaeffer M, Galai N, Nolt K, Nelson KE, Strathdee SA, Johnson L, Laeyendecker O, Boitnott J, Wilson LE, Vlahov D. The natural history of hepatitis C virus infection: host, viral, and environmental factors. JAMA. 2000;284:450–6.
Wentink MQ, Rakers M, Stupart DA, Algar U, Ramesar R, Goldberg PA. Incidence and histological features of colorectal cancer in the Northern Cape province, South Africa. S Afr J Surg. 2010;48:109–13.
World Health Organization. Evaluation of carcinogenic risk to humans. Schistosomes, liver flukes and helicobacter pylori. IARC Monogr. 1994;61:45–119.
World Health Organisation. National cancer control programmes. Policies and managerial guidelines. 2nd ed. Geneva: WHO Press; 2002. Available from: http://www.who.int/cancer/publications/nccp2002/en/
World Health Organization. Hepatitis B Factsheet No 204; 2015. http://www.who.int/mediacentre/factsheets/fs204/en/. Accessed 19 Apr 2016.
Yang BH, Bray FI, Parkin DM, Sellors JW, Zhang ZF. Cervical cancer as a priority for prevention in different world regions: an evaluation using years of life lost. Int J Cancer. 2004;109:418–24.
Zur Hausen H. Papillomaviruses in the causation of human cancers – a brief historical account. Virology. 2009;384:260–5.
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Olaleye, O., Ekrikpo, U. (2017). Epidemiology of Cancers in Sub-Saharan Africa. In: Adedeji, O. (eds) Cancer in Sub-Saharan Africa. Springer, Cham. https://doi.org/10.1007/978-3-319-52554-9_1
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