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Minimal or Mild Ovarian Stimulation for IVF: Overview

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Development of In Vitro Maturation for Human Oocytes

Abstract

The International Society of Mild Approach Assisted Reproduction (ISMAAR) defined Mild Stimulation in-vitro fertilization (MS-IVF) as ‘a method when follicle stimulating hormone (FSH) or human menopausal gonadotropin (hMG) is administered at a lower dose and or for a shorter duration in a Gonadotropin releasing hormone (GnRH)-antagonist co-treated cycle, or when oral compounds, anti-estrogens or aromatase inhibitors (AIs) are used either alone or in combination with gonadotropins (Gn) with an aim to collect a fewer number of oocytes’ (Nargund et al. in Hum Reprod 22:2801–2804, 2007 [1]). Typically, the aim of a MS cycle is to retrieve between 2 to 7 oocytes through a treatment cycle with minimum deviation from normal human physiology. Sequential clomiphene citrate (CC) and low-dose Gn in an antagonist cycle was introduced by the name of ‘minimal stimulation’ IVF (Corfman et al. in Fertility and sterility 60:864–870, 1993 [2]); many authors continue using this term to denote IVF cycles with CC or AIs with or without Gn or GnRH antagonist co-treatment (Zarek and Muasher in Fertil Steril 95(8):2449–2455, 2011 [3]; Kato et al. in Reprod Biol Endocrinol 10:35 2012 [4]). MS-IVF has also been variously termed as ‘low-intensity’ IVF, ‘low intervention’ IVF or ‘mini’ IVF. It is to be noted that MS-IVF is not synonymous with ‘natural IVF’ which is defined as: ‘..IVF is carried out with oocytes collected from a woman’s ovary or ovaries in a spontaneous menstrual cycle without administration of any medication at any time during the cycle’ or ‘administration of GnRH antagonist to block the spontaneous luteinizing hormone (LH) surge with or without FSH or HMG as add-back therapy’ (Nargund et al. in Hum Reprod 22:2801–2804, 2007 [1]).

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Authors and Affiliations

  1. Create Fertility, St. Paul’s, 150 Cheapside, London, EC2V 6ET, UK

    A.K. Datta MD, MRCOG, S. Campbell DSc (Lond), FRCP (Ed), FRCOG & G. Nargund FRCOG

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  1. A.K. Datta MD, MRCOG
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  2. S. Campbell DSc (Lond), FRCP (Ed), FRCOG
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  3. G. Nargund FRCOG
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Correspondence to A.K. Datta MD, MRCOG .

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Editors and Affiliations

  1. McGill University, Longueuil, Québec, Canada

    Ri-Cheng Chian

  2. St. George's Hospital, London, United Kingdom

    Geeta Nargund

  3. Stanford University, Palo Alto, California, USA

    Jack Y. J. Huang

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Datta, A., Campbell, S., Nargund, G. (2017). Minimal or Mild Ovarian Stimulation for IVF: Overview. In: Chian, RC., Nargund, G., Huang, J. (eds) Development of In Vitro Maturation for Human Oocytes. Springer, Cham. https://doi.org/10.1007/978-3-319-53454-1_12

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  • DOI: https://doi.org/10.1007/978-3-319-53454-1_12

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  • Online ISBN: 978-3-319-53454-1

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